Role of exfoliative cytology in the diagnosis of canine transmissible venereal tumour

1993 ◽  
Vol 34 (8) ◽  
pp. 399-401 ◽  
Author(s):  
E. K. Batamuzi ◽  
B. M. Kessy
Keyword(s):  
Exfoliative Cytology ◽  
Canine Transmissible Venereal Tumour ◽  
Transmissible Venereal Tumour

scholarly journals Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Andrea Strakova ◽  
Máire Ní Leathlobhair ◽  
Guo-Dong Wang ◽  
Ting-Ting Yin ◽  
Ilona Airikkala-Otter ◽  
...  
Keyword(s):  
Negative Selection ◽  
Nuclear Genome ◽  
Cancer Evolution ◽  
Global Migration ◽  
Transmissible Cancer ◽  
Clonal Origin ◽  
Canine Transmissible Venereal Tumour ◽  
Global Population ◽  
Transmissible Venereal Tumour

Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.

scholarly journals Multiple mutations acquired into canine RecQ-like helicases encoded by the aneuploid genome of transmissible sarcoma

2018 ◽  
Author(s):  
Wadim J. Kapulkin
Keyword(s):  
Genomic Structure ◽  
Single Gene ◽  
Domestic Dog ◽  
Dna Helicases ◽  
Structural Aberrations ◽  
Canine Transmissible Venereal Tumour ◽  
Multiple Hit ◽  
Genetic Events ◽  
Transmissible Venereal Tumour

ABSTRACTSticker sarcoma – a highly aneuploid, contagious neoplasm circulating in a domestic dog population - is broadly referred as a canine transmissible venereal tumour (CTVT). The karyotype of transmissible Sticker sarcoma appears as a collage of numerical and structural aberrations; the CTVT genome represents the generalized but stable neoplastic aneuploidy of monoclonal origins. Presented is an analysis of genetic events and variants underlying the aneuploid genomic structure of Sticker sarcoma described previously by Murchison et al. (2014) and Decker et al. (2015). Here we explored the above CTVT genomic compendia and mined the existing data - specifically looking for cases of convergence of multiple non-synonymous variants onto a single gene - the mutational patterns indicative for Knudsonian ‘two-hit’ kinetics. A Table I is given, providing theoretical estimates of retaining the intact wild-type copy, expected as a function of a cumulative mutational convergence observed in unphased sequence consensus. We demonstrate that the two canine RecQ-like helicases: Bloom syndrome helicase and RECQL4, encoded by the aneuploid transmissible tumour, have accumulated a multitude of different mutations. Among the sets of most intensely mutated transmissible sarcoma genes, we also identified a canine FANCD2 – yet another previously unnoticed multiple-hit candidate factor. We discuss a possible role of mutated RecQ-like helicases and other cooperating factors, perceivably involved in the maintenance of the neoplastic aneuploidy. We suggest the proposed cooperative actions of CTVT RecQ-like DNA helicases could be relevant interpreting whether variants contributing to RecQ-dependent karyotypic traits, respond to selective pressures that preserve the aneuploid genomic structure of transmissible Sticker sarcoma.

scholarly journals Role of micronucleus in oral exfoliative cytology

2015 ◽  
Vol 7 (6) ◽  
pp. 409 ◽  
Author(s):  
BK Akshatha ◽  
R Shashikala ◽  
AP Indira ◽  
GS Manjunath ◽  
KArathi rao
Keyword(s):  
Exfoliative Cytology ◽  
Oral Exfoliative Cytology

Role of exfoliative cytology in carcinoma larynx

1968 ◽  
Vol 20 (4) ◽  
pp. 178-184
Author(s):  
B. K. Roy Chaudhuri ◽  
A. Sinha ◽  
B. M. Abrol
Keyword(s):  
Exfoliative Cytology ◽  
Carcinoma Larynx

Treatment of Canine Transmissible Venereal Tumour using Different Surgico-chemotherapeutic Protocols

2021 ◽  
Author(s):  
Nutan Punchkande ◽  
Rukmani Dewangan ◽  
Raju Sharda ◽  
D. Jolhe ◽  
Dhaleshwari Sahu ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Treatment Protocols ◽  
Post Surgery ◽  
Vincristine Sulphate ◽  
Group A ◽  
Group B ◽  
Canine Transmissible Venereal Tumour ◽  
Transmissible Venereal Tumour

Background: Canine transmissible venereal tumour (CTVT) also known as infectious sarcoma, venereal granuloma, transmissible lymphosarcoma or sticker tumour is usually transmitted through coitus and mainly affects the external genitalia of young sexually matured dogs. Surgery, chemotherapy, radiotherapy and immunotherapy are considered as effective treatment protocols. Therefore, depending upon the availability present study was designed to investigate the efficacy of different surgico-chemotherapeutic protocols for treatment of canine transmissible venereal tumour.Methods: The study was conducted during January 2018 to July 2018 at the Teaching Veterinary Clinical Complex (TVCC) and Department of Veterinary Surgery and Radiology, College of Veterinary Science and A.H., Anjora, Durg (C.G.) on 18 canines of various breed, irrespective of age, sex and divided into three groups consisting 6 animals in each group. Group A was treated with surgical excision of tumour only where as Group B and Group C were treated with surgical excision of tumour followed by administration of Doxorubicin (30mg/m2) BSA and Vincristine sulphate (0.025 mg/kg) intravenously alongwith DNS at 7th and 14th post-operative days respectively. Different physiological and haemato-biochemical parameters (Hb, PCV, TLC, TPC, DLC, serum glucose, TSP, SUN, SC, ALT, AST and ALP) were recorded preoperatively, postoperatively and after chemotherapy at 10th, 30th and 60th days intervals.Result: The present investigation showed transient changes in physiological and haemato-biochemical parameters before, post surgery and post chemotherapeutic management and was within normal range. Histopathological examination revealed confluent sheet of tumour cells arranged in large round oval or polyhedral shaped distributed in tight clusters or cords. Group A showed mild to moderated reoccurrence while Group B showed minimum reoccurrence. Group C showed no reoccurrence. Thus, surgery combined with vincristine therapy is most effective for treating dogs suffering with transmissible venereal tumour.

scholarly journals Evaluation of a genetic assay for canine transmissible venereal tumour diagnosis in Brazil

2016 ◽  
Vol 15 (2) ◽  
pp. 615-618 ◽  
Author(s):  
K. F. Castro ◽  
A. Strakova ◽  
M. Tinucci-Costa ◽  
E. P. Murchison
Keyword(s):  
Tumour Diagnosis ◽  
Canine Transmissible Venereal Tumour ◽  
Transmissible Venereal Tumour ◽  
Genetic Assay

scholarly journals Nasal Transmissible Venereal Tumor In A Jack Russel Terrier Bitch

2015 ◽  
Vol 65 (1) ◽  
pp. 143-148 ◽  
Author(s):  
FEGHIU Adrian ◽  
CRÎNGANU Dan ◽  
DUMITRESCU Florin ◽  
PASCAL Manuela ◽  
VASILESCU Florina ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Veterinary Medicine ◽  
Nasal Cavity ◽  
Tumor Tissue ◽  
Left Nasal Cavity ◽  
Vincristine Sulphate ◽  
Positive Immunoreactivity ◽  
Canine Transmissible Venereal Tumour ◽  
Transmissible Venereal Tumour ◽  
Primary Form

Abstract A two-year old Jack Russell Terrier female with left-sided epistaxis was brought to the Clinic of the Bucharest Faculty of Veterinary Medicine. Endoscopy of the left nasal cavity revealed a cauliflower-like mass. Cytological and histopathological features were specific to canine transmissible venereal tumour (CTVT). Tumor tissue showed positive immunoreactivity to anti-vimentin monoclonal antibody (90%) and Ki67 (35%) and samples were negative for anti-cytokeratin monoclonal antibody. Chemotherapy with vincristine sulphate at a dose of 0.025 mg/kg i.v./week for 6 administrations was successful. This paper presents a primary form of nasal CTVT in a Jack Russell Terrier female.

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