FAT-FREE PARENTERAL ALIMENTATION OF INFANTS

SummaryIn 8 patients on no oral intake and with parenteral alimentation, administration of cephalosporins with N-methyl-thiotetrazole side chain (moxalactam, cefamandole), was associated with prolongation of prothrombin time, appearance in the circulation of descarboxy-prothrombin (counter immunoelectrophoresis and echis carinatus assay) and diminution of protein C. Acute administration of 10 mg vitamin Ki was followed by the transient appearance of vitamin K1 2,3-epoxide, indicating an impaired hepatocellular regeneration of vitamin K1 from the epoxide. Impaired hepatic vitamin K1 metabolism, tentatively ascribed to the N-methyl-thiotetrazole group, is one (but possibly not the only) cause of bleeding complications and depression of vitamin K1dependent procoagulants in patients treated with the new class of cephalosporins.

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PREDICTION OF SUCCESS OR FAILURE OF PARENTERAL ALIMENTATION IN THE TREATMENT OF SEVERE FORMS OF CROHN'S DISEASE AND RECTOCOLITIS

Proceedings of the Second Symposium Lyon, France, June 27–30, 1983 ◽

10.1515/9783112328262-071 ◽

1984 ◽

pp. 523-526

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Parenteral Alimentation

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Adverse effects of xylitol in parenteral alimentation

Metabolism ◽

10.1016/0026-0495(71)90096-5 ◽

1971 ◽

Vol 20 (4) ◽

pp. 345-347 ◽

Cited By ~ 31

Author(s):

William Schumer

Keyword(s):

Adverse Effects ◽

Parenteral Alimentation

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Kwashiorkor in the United States

PEDIATRICS ◽

10.1542/peds.66.6.972 ◽

1980 ◽

Vol 66 (6) ◽

pp. 972-976

Author(s):

H. Peter Chase ◽

Vijay Kumar ◽

Richard T. Caldwell ◽

Donough O'Brien

Keyword(s):

United States ◽

Heart Failure ◽

Congestive Heart Failure ◽

Skin Rash ◽

The United States ◽

Protein Restriction ◽

Bleeding Tendency ◽

Parenteral Alimentation

Kwashiorkor, with typical edema and skin rash is occasionally seen in affluent countries as a result of severe protein restriction. Treatment is with a lactose-free formula after rehydration and sometimes after a period of parenteral alimentation. Complications of therapy included: diarrhea, congestive heart failure, infections, a bleeding tendency, and seizures. Two of the 14 children in this series died.

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