Pregnancy and radiotherapy: Management options for minimising risk, case series and comprehensive literature review

2009 ◽  
Vol 53 (6) ◽  
pp. 559-568 ◽  
Author(s):  
SA Luis ◽  
DRH Christie ◽  
A Kaminski ◽  
L Kenny ◽  
MH Peres
Keyword(s):  
Literature Review ◽  
Case Series ◽  
Management Options ◽  
Comprehensive Literature Review

Subcutaneous levetiracetam for the management of seizures at the end of life

2017 ◽  
Vol 8 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Anna Elizabeth Sutherland ◽  
John Curtin ◽  
Victoria Bradley ◽  
Olivia Bush ◽  
Maggie Presswood ◽  
...  
Keyword(s):  
Palliative Care ◽  
Literature Review ◽  
End Of Life ◽  
Terminal Care ◽  
Seizure Control ◽  
Case Reports ◽  
Subcutaneous Administration ◽  
Case Series ◽  
Comprehensive Literature Review ◽  
Randomised Controlled

ObjectivesTo report the results of a combined case series analysis of subcutaneous levetiracetam (Keppra) for the management of seizures in palliative care patients.MethodsA comprehensive literature review on the use of subcutaneous levetiracetam was performed, and these data were combined with a prospective observational audit of its use in terminal care undertaken in a regional palliative care network.Results7 papers were identified from the literature review-four case reports and three observational case series-reporting on a total of 53 cases where subcutaneous levetiracetam was administered.We report 20 further cases of subcutaneous levetiracetam administration from a prospective observational audit. Doses ranged from 250mg to 4000 mg daily. Oral to subcutaneous conversion ratios where stated were 1:1. Levetiracetam was reported as the sole administered antiepileptic drug (AED) in eight cases, and no seizures were reported until death in five cases. Five were switched back to enteral levetiracetam. In seven cases, levetiracetam was combined with AEDs to provide seizure control at the end of life. There was one report of a sterile abscess after 25 days of continuous subcutaneous administration.ConclusionsCombined analysis of 73 reported cases of subcutaneous levetiracetam suggests this treatment may have a role in the management of seizures at the end of life. However, randomised controlled trials are urgently needed to establish the efficacy and tolerability of subcutaneous levetiracetam administration. If proven to be safe and effective, subcutaneous levetiracetam offers the potential to prevent and treat seizures without causing unnecessary sedation at the end of life.

scholarly journals Burns associated with e-cigarette batteries: A case series and literature review

CJEM ◽  
2017 ◽  
Vol 20 (S2) ◽  
pp. S20-S28 ◽  
Author(s):  
Jamie Harshman ◽  
Miliana Vojvodic ◽  
Alan D. Rogers
Keyword(s):  
North America ◽  
Literature Review ◽  
Acute Care ◽  
Burn Injury ◽  
Electronic Cigarettes ◽  
Case Series ◽  
Burn Injuries ◽  
Injury Patterns ◽  
Comprehensive Literature Review ◽  
Appropriate Treatment

AbstractElectronic cigarettes, often referred to ase-cigarettes, have established a considerable market in North America over the last decade. In parallel to this trend, there has been a surge of e-cigarette battery explosions reported in the general media. Given the growing number of such events, acute care physicians should recognize the associated risks and injury patterns and initiate appropriate treatment. This report presents two cases of burn injuries from e-cigarette battery explosions requiring surgical management. The accompanying comprehensive literature review highlights the emerging importance of e-cigarettes as an aetiology of burn injury.

Bartonella and Coxiella infections presenting as systemic vasculitis: case series and review of literature

Rheumatology ◽  
2021 ◽  
Author(s):  
Maxime Beydon ◽  
Christophe Rodriguez ◽  
Alexandre Karras ◽  
Alexandre Cez ◽  
Cédric Rafat ◽  
...  
Keyword(s):  
Literature Review ◽  
Systemic Vasculitis ◽  
Case Series ◽  
Sequencing Analysis ◽  
Bacterial Dna ◽  
Anca Associated Vasculitis ◽  
Comprehensive Literature Review ◽  
Highly Sensitive ◽  
Next Generation Sequencing Analysis ◽  
Generation Sequencing

Abstract Objectives Coxiella and Bartonella sp. display particular tropism for endothelial or endocardial tissues and an abnormal host response to infections with induced autoimmunity. We aimed, through a case series combined with a comprehensive literature review, to outline characteristics of Coxiella and Bartonella infections presenting as systemic vasculitis. Methods We retrospectively included cases of definite Coxiella and Bartonella infections presenting with vasculitis features and performed a comprehensive literature review. Results Six cases of Bartonella infections were added to 18 cases from literature review. Causative pathogens were mainly B. henselae. Bartonella infection mimicked anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis in 83% with PR3-ANCA and presented as cryoglobulinemic vasculitis in 8%. Glomerulonephritis was present in 92%, and 88% had endocarditis. Complement fractions were low in 82% and rheumatoid factor positive in 85%. Kidney biopsies showed cell proliferation, mostly crescentic, with pauci-immune glomerulonephritis in 29%. Outcome was favorable, with the use of antibiotics alone in one third. Five cases of Coxiella infections were added to 16 from literature review. Sixteen had small-vessel vasculitides, mainly cryoglobulinemia vasculitis in 75%. One patient had polyarteritis nodosa-like vasculitis and four large-vessel vasculitis. Outcome was good except for one death. A highly sensitive next generation sequencing analysis on 3 Coxiella and 2 Bartonella-related vasculitides biopsies did not find any bacterial DNA. Conclusion Coxiella and Bartonella are both able to induce vasculitis but display distinct vasculitis features. Bartonella mimics PR3-ANCA-associated vasculitis in the setting of endocarditis, whereas Coxiella may induce vasculitis involving all vessel sizes.

scholarly journals AGGRESSIVE VERTEBRAL HEMANGIOMAS – CASE SERIES AND LITERATURE REVIEW

2020 ◽  
Vol 19 (4) ◽  
pp. 293-296
Author(s):  
LUCAS XAVIER DA LUZ ◽  
MARCELO SIMONI SIMÕES ◽  
BRUNO DE AZEVEDO OLIVEIRA ◽  
GUILHERME JOSÉ MIOTTO ◽  
ERNANI VIANNA DE ABREU
Keyword(s):  
Literature Review ◽  
Treatment Options ◽  
Case Series ◽  
Neurological Deficits ◽  
Subtotal Resection ◽  
Decompression Surgery ◽  
Management Options ◽  
Level Of Evidence ◽  
Vertebral Hemangiomas

ABSTRACT Objectives To present a series of aggressive hemangiomas of the institution, with a review of the management options described in the literature. Methods This is a retrospective survey of aggressive vertebral hemangiomas treated by the service in the last 10 years, with histological confirmation of the diagnosis and a minimum follow-up of 1 year. The case analysis and literature review were conducted with emphasis on treatment options for these injuries. Results Seven cases were found, three with pain and four with severe neurological deficits. Two patients were treated with open decompression, one with open decompression and cementation, one with open decompression and arthrodesis, one with biopsy and cementation, one with percutaneous biopsy, and one with open biopsy followed by decompression surgery. All patients underwent radiotherapy. There was a significant regression of presentation deficits, but one patient developed an irreversible deficit during treatment. There were no recurrences or late complications in the follow-up period. Conclusions Surgical decompression in patients with significant neurological deficit is a point of consensus in the literature. Subtotal resection followed by radiation therapy was effective in treating deficits and controlling pathology. Cases manifesting pain only can be managed with minimally invasive techniques, whether or not they are followed by radiotherapy. Level of evidence IV; Therapeutic study of case series.

scholarly journals Persistent median artery carpal tunnel syndrome: a case series and literature review

2019 ◽  
Vol 2 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Jake L Nowicki ◽  
Alexander Macgregor Cameron ◽  
Philip Griffin ◽  
Quoc Tai Khoa Lam ◽  
Nicholas Marshall
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Literature Review ◽  
Median Nerve ◽  
Carpal Tunnel ◽  
Case Series ◽  
Management Options ◽  
Tunnel Syndrome ◽  
Median Artery

Persistent median artery (PMA) thrombosis is a rare cause of carpal tunnel syndrome (CTS) with only a few cases reported in the literature. The bifid median nerve (BMN) is often associated with PMA and may be a factor in the development of CTS. There is a paucity of information in the literature on the management options for CTS secondary to PMA thrombosis. This paper presents two cases of CTS with associated PMA thrombosis and BMN and offers a discussion on diagnostic and management options.

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