Contribution of Passive Transport Mechanisms to the Intestinal Absorption of β-Lactam Antibiotics

1990 ◽  
Vol 42 (5) ◽  
pp. 314-318 ◽  
Author(s):  
Mitsuru Sugawara ◽  
Hiroshi Saitoh ◽  
Ken Iseki ◽  
Katsumi Miyazaki ◽  
Takaichi Arita
Keyword(s):  
Intestinal Absorption ◽  
Transport Mechanisms ◽  
Passive Transport

Absorption from gastrointestinal tract of the rat after x-irradiation

1961 ◽  
Vol 201 (6) ◽  
pp. 1013-1016 ◽  
Author(s):  
Maurice F. Sullivan
Keyword(s):  
Nitrogen Mustard ◽  
Direct Action ◽  
Glucose Absorption ◽  
The Other ◽  
Transport Mechanisms ◽  
Passive Transport ◽  
Sugar Absorption ◽  
In Situ Perfusion ◽  
X Irradiation

An in situ perfusion method was used to measure glucose absorption from the x-irradiated or nitrogen-mustard-treated rat. Inhibition was greatest 3 days after treatment and recovery had begun by the 6th day. The effect on absorption was not appreciably different after 900 r than after 1,500 r, although histologic damage was much greater after the higher dose. Pretreatment with cysteine or AET prevented the decreased absorption after 900 r but did not protect against 1,500 r nor against the effect of HN2. The absorption of d(+)-xylose was also decreased 3 days after irradiation of the intestine. Thus, both active and passive transport mechanisms involved in sugar absorption were decreased by irradiation of the intestine. The absorption of fat, on the other hand, was not decreased as a result of direct action by x-radiation on the intestinal epithelium, since oleic acid absorption was unaffected by exposure of the intestine to radiation.

scholarly journals A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms

2014 ◽  
Vol 31 (8) ◽  
pp. 2010-2021 ◽  
Author(s):  
Shmuel Tuvia ◽  
Dori Pelled ◽  
Karen Marom ◽  
Paul Salama ◽  
Maya Levin-Arama ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Transport Mechanisms ◽  
Suspension Formulation

scholarly journals Intestinal absorption of S-nitrosothiols: Permeability and transport mechanisms

2018 ◽  
Vol 155 ◽  
pp. 21-31 ◽  
Author(s):  
Justine Bonetti ◽  
Yi Zhou ◽  
Marianne Parent ◽  
Igor Clarot ◽  
Haiyan Yu ◽  
...  
Keyword(s):  
Intestinal Absorption ◽  
Transport Mechanisms

Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells

2019 ◽  
Vol 10 (8) ◽  
pp. 5215-5227 ◽  
Author(s):  
Yufeng Chen ◽  
Fan Xue ◽  
Guobin Xia ◽  
Zhenlei Zhao ◽  
Chun Chen ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Transepithelial Transport ◽  
Efflux Transporters ◽  
Transport Mechanisms ◽  
Passive Transport ◽  
Cell Monolayers ◽  
Trkb Receptor

7,8-DHF was transported across Caco-2 cell monolayers by passive transport with carrier-mediated influx and efflux transporters.

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