GAMMA SCINTIGRAPHIC EVALUATION AND SIMULTANEOUS PLASMA ANALYSIS OF RAPID RELEASE KETOPROFEN SEMI-SOLID MATRIX CAPSULES

1990 ◽  
Vol 42 (S1) ◽  
pp. 149P-149P
Author(s):  
A.B. Dennis ◽  
S. Farr ◽  
I.W. Kellaway ◽  
G. Taylor ◽  
R. Davidson
Keyword(s):  
Solid Matrix ◽  
Plasma Analysis ◽  
Rapid Release ◽  
Semi Solid

scholarly journals High speed DSC (hyper-DSC) as a tool to measure the solubility of a drug within a solid or semi-solid matrix

2005 ◽  
Vol 301 (1-2) ◽  
pp. 1-5 ◽  
Author(s):  
Daniela Gramaglia ◽  
Barbara R. Conway ◽  
Vicky L. Kett ◽  
R. Karl Malcolm ◽  
Hannah K. Batchelor
Keyword(s):  
High Speed ◽  
Solid Matrix ◽  
Semi Solid

scholarly journals Life in frozen veins: Coping with the cold

2005 ◽  
Vol 27 (1) ◽  
pp. 12-16
Author(s):  
David N. Thomas ◽  
Thomas Mock
Keyword(s):  
Water Column ◽  
Surface Waters ◽  
Food Source ◽  
Solid Matrix ◽  
Unicellular Algae ◽  
Microbial Assemblage ◽  
Rich Food ◽  
Polar Oceans ◽  
Semi Solid

Every autumn a fundamental transition occurs in the surface waters of polar oceans. Millions of square kilometres of surface waters freeze to form an ice layer that varies from a few centimetres through to several metres thick, and which effectively separates the ocean from the atmosphere above. Ice made from seawater is a porous, semi-solid matrix permeated by a labyrinth of brine channels and pores, and within these a diverse microbial assemblage, including viruses, Archaea, bacteria, flagellates and unicellular algae can thrive. These assemblages can reach such high abundances that the ice becomes a rich coffee colour. The microbial assemblages are in turn a rich food source for grazing protoplankton and zooplankton, especially in winter when food in the water column is scarce.

Phase I dose escalation and safety study of a semi-solid matrix (SSM) formulation of oral irinotecan and capecitabine tablets in patients with advanced solid tumors

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 2042-2042 ◽  
Author(s):  
A. I. B. Benson ◽  
E. Rubin ◽  
S. Beers ◽  
P. Mucci-Lorusso ◽  
W. Vermuelen ◽  
...  
Keyword(s):  
Phase I ◽  
Solid Tumors ◽  
Dose Escalation ◽  
Solid Matrix ◽  
Advanced Solid Tumors ◽  
Safety Study ◽  
Semi Solid

scholarly journals Micro-encapsulation extends mycelial viability of Streptomyces lividans 66 and increases enzyme production

2017 ◽  
Author(s):  
Boris Zacchetti ◽  
Agathoklis Andrianos ◽  
Dino van Dissel ◽  
Evelien de Ruiter ◽  
Gilles P. van Wezel ◽  
...  
Keyword(s):  
Slow Growth ◽  
Extracellular Enzyme ◽  
Downstream Processing ◽  
Streptomyces Lividans ◽  
Culture Broth ◽  
Solid Matrix ◽  
Nutrient Transfer ◽  
Process Dynamics ◽  
Intracellular Proteins ◽  
Semi Solid

AbstractBackgroundFilamentous bacteria of the genus Streptomyces produce a large arsenal of industrially relevant antibiotics and enzymes. The industrial production of these molecules occurs in large fermenters, where many streptomycetes form dense mycelial networks called pellets. Pellets are characterized by slow growth and inefficient nutrient transfer and therefore regarded as undesirable from the perspective of productivity. Although non-pelleting strains have increased growth rates, their morphology also leads to a dramatic increase in the viscosity of the culture broth, which negatively impacts the process dynamics.ResultsHere, we applied immobilization of Streptomyces lividans 66 using alginate as semi-solid matrix. This alginate-mediated micro-encapsulation increased the production of the extracellular enzyme tyrosinase more than three-fold. The increased production was accompanied by extended viability of the mycelium and a dramatic reduction in the release of intracellular proteins into the culture broth.ConclusionsOur data demonstrate the utility of microencapsulation as a powerful technique to achieve higher yields and lower downstream-processing costs of streptomycetes.

scholarly journals Bioprinting transgenic plant cells for production of a recombinant biodefense agent

2021 ◽  
Author(s):  
Anika Varma ◽  
Hawi B. Gemeda ◽  
Matthew J. McNulty ◽  
Karen A. McDonald ◽  
Somen Nandi ◽  
...  
Keyword(s):  
Plant Cells ◽  
Recovery Phase ◽  
Solid Matrix ◽  
Free Medium ◽  
Sugar Consumption ◽  
Product Separation ◽  
The Media ◽  
Bioreactor System ◽  
Semi Solid ◽  
Cocaine Toxicity

AbstractTransgenic rice cells (Oryza sativa) producing recombinant butyrylcholinesterase (BChE) as a prophylactic/therapeutic against organophosphate nerve agent poisoning, cocaine toxicity, and neurodegenerative diseases like Alzheimer’s were immobilized in a polyethylene glycol-based hydrogel. The cells were sustained for 14 days in the semi-solid matrix, undergoing a growth phase from days 0-6, a BChE production phase in sugar-free medium from days 6-12, and a growth/recovery phase from days 12-14. Throughout this period, the cells maintained similar viability to those in suspension cultures and displayed analogous sugar consumption trends. The rice cells in the bioprintable hydrogel also produced a significant amount of active BChE, comparable to the levels produced in liquid cultures. A considerable fraction of this BChE was secreted into the media, allowing for easier product separation. Overall, we demonstrate a simple, efficient, robust, modular, and potentially field-deployable bioreactor system for the manufacture of biologics.

Effect of Ultrasonic Vibration on the Dispersion of Carbon Nano-Fibre Reinforcement through Semi-Solid AZ91D Magnesium Alloy

2006 ◽  
Vol 116-117 ◽  
pp. 392-396 ◽  
Author(s):  
R.G.S. Mussi ◽  
Tetsuichi Motegi ◽  
Fumi Tanabe ◽  
H. Kawamura ◽  
K. Anzai ◽  
...  
Keyword(s):  
Magnesium Alloy ◽  
Grain Refinement ◽  
Ultrasonic Vibration ◽  
Solid Fraction ◽  
Solid Matrix ◽  
Fibre Reinforcement ◽  
Cooling Plate ◽  
Mechanical Stirring ◽  
Az91d Magnesium Alloy ◽  
Semi Solid

Ultrasonic vibration was applied to the surface of AZ91D/CNF slurries in order to homogeneously disperse the reinforcement through the semi-solid matrix, and eliminate the clusters of nano-fibres originated during previous processes. The method utilized to produce the slurry was a modified compocasting process that generates semi-solid magnesium alloy using an inclined cooling plate and mechanical stirring. The CNF reinforcement was added in quantities varying from 1 to 3vol% and different vibration times and amplitudes were applied to the slurries under isothermal conditions. Macro and microstructure combined analysis showed the occurrence of grain refinement in the whole ingot for higher wave amplitudes at shorter times, while for lower amplitudes longer times up to 10min. were required. Vibration times over 10min were not significant to further improve the results and times up to 4min did not seem to provide any result whatsoever. The best results, however, were obtained for 16 and 18μm amplitudes. Discontinuous application of ultrasound seems to produce better results than continuous vibration. The dispersion of reinforcement seems to occur by the smash of CNF clusters due to the movement of the solid fraction present in the Mg alloy slurry, and by cavitation, responsible also for some microporosity present in the microstructures.

Drug Release from Semi-Solid Matrix Systems in Hard Capsules

1989 ◽  
Vol 15 (14-16) ◽  
pp. 2407-2417 ◽  
Author(s):  
C. Mathis ◽  
J. Heimendinger
Keyword(s):  
Drug Release ◽  
Solid Matrix ◽  
Semi Solid
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