scholarly journals Nocturnal blood pressure surge in seconds is a new determinant of left ventricular mass index

2021 ◽  
Author(s):  
Ayako Kokubo ◽  
Mitsuo Kuwabara ◽  
Yuki Ota ◽  
Naoko Tomitani ◽  
Shingo Yamashita ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Ventricular Mass Index ◽  
Nocturnal Blood Pressure ◽  
Ventricular Mass ◽  
Pressure Surge

Is the burden of late hypertension and cardiovascular target organ damage in children and adolescents with coarctation of the aorta after early successful repair different to healthy controls?

2020 ◽  
Vol 30 (9) ◽  
pp. 1305-1312
Author(s):  
Ayşe Ağbaş ◽  
Selman Gökalp ◽  
Nur Canpolat ◽  
Salim Çalışkan ◽  
Funda Öztunç
Keyword(s):  
Blood Pressure ◽  
Children And Adolescents ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Coarctation Of The Aorta ◽  
Left Ventricular ◽  
Masked Hypertension ◽  
Ventricular Mass Index ◽  
Ventricular Mass ◽  
Successful Repair

AbstractObjective:Cardiovascular morbidity is high in patients with coarctation of aorta even after successful repair. This study aimed to assess the frequency of late hypertension and the relationship between ambulatory hypertension and cardiovascular target organ damage in children and adolescents after early and successful repair of coarctation of the aorta.Methods:Twenty-five children and adolescents (mean age 13.5 ± 3.43 years) with repaired coarctation of the aorta (median age at repair 4 months, arm–leg gradient <20 mmHg) and 16 healthy controls were included. Office and ambulatory blood pressure, pulse wave velocity, and left ventricular mass index were assessed.Results:Both day- and night-time systolic blood pressure standard deviation score and left ventricular mass index were significantly higher in patients compared to controls (p ≤ 0.001 for all), whereas pulse wave velocity did not differ. The prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy were 40, 28, and 24%, respectively. Left ventricular mass index was higher in patients with sustained hypertension, masked hypertension, and normotension compared to controls (p < 0.05). In multivariate analysis, higher night-time systolic blood pressure standard deviation score was the only independent predictor of left ventricular mass index.Conclusion:The present study reveals a high prevalence of masked hypertension, isolated nocturnal hypertension, and left ventricular hypertrophy in children and adolescents with coarctation of the aorta even after early and successful repair. Ambulatory blood pressure monitoring should be considered to diagnose hypertension. All coarctation of aorta patients should be followed up lifelong and encouraged to establish a healthy lifestyle starting from childhood.

Blood pressure, left ventricular mass and intracellular calcium in primary hyperparathyroidism

1990 ◽  
Vol 78 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Anna F. Dominiczak ◽  
Fiona Lyall ◽  
James J. Morton ◽  
Henry J. Dargie ◽  
Iain T. Boyle ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Confidence Interval ◽  
Primary Hyperparathyroidism ◽  
Left Ventricular Mass ◽  
Left Ventricular Mass Index ◽  
Left Ventricular ◽  
Free Calcium ◽  
Ventricular Mass Index ◽  
Control Subjects ◽  
Ventricular Mass

1. Blood pressure, left ventricular mass and platelet cytosolic free calcium concentrations were measured in 23 patients with untreated primary hyperparathyroidism, 30 normotensive control subjects and 23 control subjects matched for age, sex and blood pressure. In 12 patients measurements were repeated after parathyroidectomy. 2. Patients with primary hyperparathyroidism had significantly elevated blood pressures (139 ± 6/86 ± 3 mmHg, mean ± sem) compared with control subjects (125 ± 2/78 ± 1 mmHg), but high values persisted after hypercalcaemia was corrected. 3. Despite chronic extracellular hypercalcaemia, intracellular free calcium levels were lower in patients with hyperparathyroidism than in controls matched for age, sex and blood pressure (median concentrations 81.5 nmol/l vs 93 nmol/l, 95% confidence interval 0.1 to 20.1; P < 0.05) and values tended to increase after parathyroidectomy. 4. Left ventricular mass index was increased in the primary hyperparathyroid group as compared with control subjects matched for age, sex and blood pressure (123 g/m2 vs 100 g/m2, 95% confidence interval −36.1 to −3.1; P = 0.03). Parathyroidectomy resulted in a small reduction of the left ventricular mass index (123.5 g/m2 vs 104 g/m2, 95% confidence interval 46.5 to 2.5; P = 0.1) but no change in blood pressure. 5. Hypertension and left ventricular hypertrophy in primary hyperparathyroidism are associated with relatively low levels of free calcium in platelets.

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