Repair of segmental mandibular bone defects in sheep using bone marrow stromal cells and autologous serum scaffold: a pilot study

2015 ◽  
Vol 42 (12) ◽  
pp. 1143-1151 ◽  
Author(s):  
Lorena Gallego ◽  
Marcos Pérez-Basterrechea ◽  
Luis García-Consuegra ◽  
María Álvarez-Viejo ◽  
Joaquim Megías ◽  
...  
Biomaterials ◽  
2007 ◽  
Vol 28 (6) ◽  
pp. 1005-1013 ◽  
Author(s):  
Jie Yuan ◽  
Lei Cui ◽  
Wen Jie Zhang ◽  
Wei Liu ◽  
Yilin Cao

2010 ◽  
Vol 16 (4) ◽  
pp. 1385-1394 ◽  
Author(s):  
Jie Yuan ◽  
Wen Jie Zhang ◽  
Guangpeng Liu ◽  
Min Wei ◽  
Zuo Liang Qi ◽  
...  

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Xuehui Zhang ◽  
Mingming Xu ◽  
Xinggang Liu ◽  
Feng Zhang ◽  
Yan Wei ◽  
...  

Nano-β-tricalcium phosphate/collagen (n-β-TCP/Col) is considered with good osteoconductivity. However, the therapeutic effectiveness of n-β-TCP/Col scaffolds in combination with autologous bone marrow stromal cells (BMSCs) remains to be elucidated for the repair of critical-sized bone defects. In this study, we found that n-β-TCP/Col scaffolds exhibited high biocompatibilityin vitro. The introduction of BMSCs expandedin vitroto the scaffolds dramatically enhanced their efficiency to restore critical-sized bone defects, especially during the initial stage after implantation. Collectively, these results suggest that autologous BMSCs in n-β-TCP/Col scaffolds have the potential to be applied in bone tissue engineering.


2008 ◽  
Vol 368-372 ◽  
pp. 1235-1237 ◽  
Author(s):  
Lei Liu ◽  
Run Liang Chen ◽  
Yun Feng Lin ◽  
Wei Dong Tian ◽  
Sheng Wei Li

Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility, biological degradability, and porosity. This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold. In this study, critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP. The resulting grafts were examined by X-ray, histological examination, semi-quantitative analysis of osteogenesis, immunochemical examination (collagen type I and III), scanning electron microscopy and transmission electron microscopy. The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.


2012 ◽  
Vol 74 (6) ◽  
pp. 817-820 ◽  
Author(s):  
Kazuya EDAMURA ◽  
Takashi KUROSAWA ◽  
Rei NAKANO ◽  
Kenji TESHIMA ◽  
Kazushi ASANO ◽  
...  

2019 ◽  
Vol 30 (S19) ◽  
pp. 79-79
Author(s):  
Fumio Suehiro ◽  
Masakazu Ishii ◽  
Naohiro Komabashiri ◽  
Tomohiro Masuzaki ◽  
Shinichiro Kawamoto ◽  
...  

2014 ◽  
Vol 12 (1) ◽  
pp. 123 ◽  
Author(s):  
Yefei Wang ◽  
Xiaoping Bi ◽  
Huifang Zhou ◽  
Yuan Deng ◽  
Jing Sun ◽  
...  

2012 ◽  
Vol 30 (2) ◽  
pp. 127-136 ◽  
Author(s):  
Fukuki Saito ◽  
Toshio Nakatani ◽  
Masaaki Iwase ◽  
Yuji Maeda ◽  
Yoshinori Murao ◽  
...  

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