scholarly journals Antibiotic stewardship: Early discontinuation of antibiotics based on procalcitonin level in COVID‐19 pneumonia

2021 ◽  
Author(s):  
Archana Roy ◽  
Harry Ross Powers ◽  
Emily C. Craver ◽  
Mark D. Nazareno ◽  
Siva Naga S. Yarrarapu ◽  
...  
Keyword(s):  
Antibiotic Stewardship ◽  
Early Discontinuation ◽  
Procalcitonin Level

scholarly journals EARLY DISCONTINUATION OF ANTIBIOTICS BASED ON PROCALCITONIN LEVEL IN COVID-19 PNEUMONIA

CHEST Journal ◽  
2021 ◽  
Vol 160 (4) ◽  
pp. A1099
Author(s):  
Archana Roy ◽  
Siva Naga Yarrarapu ◽  
Mark Nazareno ◽  
Devang Sanghavi
Keyword(s):  
Early Discontinuation ◽  
Procalcitonin Level

scholarly journals Bacterial coinfections with coronavirus disease 2019 (COVID-19)

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Glen Huang ◽  
Daisuke Furukawa ◽  
Bryant D. Yang ◽  
Brian J. Kim ◽  
Arthur C. Jeng
Keyword(s):  
Antibiotic Stewardship ◽  
Chart Review ◽  
Retrospective Chart Review ◽  
Blood Cultures ◽  
Procalcitonin Level ◽  
Good Target ◽  
Clinically Significant ◽  
Time Of Presentation ◽  
Respiratory Coronavirus

Abstract Background: The pandemic caused by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) has dramatically increased cheshospitalizations, and it is often difficult to determine whether there is a bacterial or fungal coinfection at time of presentation. In this study, we sought to determine the rates of coinfection and utilization of antibiotics in SARS-CoV-2 disease. Methods: Retrospective chart review of patients hospitalized with COVID-19 pneumonia from April 13, 2020, to July 14, 2020. Results: In total, 277 patients were hospitalized for COVID-19 pneumonia during this period. Patients that received antibiotics within 48 hours of presentation were more likely to be febrile (59.3% vs 41.2%; P = .01) and to have leukocytosis (23.9% vs 5.9%; P < .01) and were less likely to have a procalcitonin level <0.25 ng/mL (58.8% vs 74.5%; P = .04). In total, 45 patients had positive blood cultures collected during hospitalization, 16 of which were clinically significant. Of the clinically significant blood cultures, 5 were collected <48 hours of admission. Moreover, 18 sputum cultures were clinically significant, 2 of which were collected within 48 hours of admission. Conclusion: Bacterial and fungal coinfections in COVID-19 appear to be rare on presentation; thus, this factor may be a good target for enhanced antibiotic stewardship.

scholarly journals 2050. Effect of a Stewardship Intervention on Post-Prescriptive Antibiotic Timeouts in Nursing Homes

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S691-S691
Author(s):  
Chi-Yin Liao ◽  
James H Ford ◽  
David A Nace ◽  
Christopher Crnich
Keyword(s):  
Nursing Homes ◽  
Antibiotic Stewardship ◽  
Common Type ◽  
Antibiotic Prescribing ◽  
Dose Frequency ◽  
Early Discontinuation ◽  
Antibiotic Overuse ◽  
Before And After ◽  
The Difference

Abstract Background Antibiotic overuse and misuse is a common problem in nursing homes (NHs). Meaningful improvements in the quality of antibiotic prescribing in NHs may be improved through post-prescriptive interventions (antibiotic timeouts) focused on stopping, streamlining and/or shortening ongoing antibiotic treatments. A recently completed trial of a complex antibiotic stewardship intervention provided us with an opportunity to explore to what extent NH providers engaged in antibiotic timeouts at baseline and the effects of the intervention on these behaviors. Methods Data on antibiotic prescriptions in 11 NHs (6 intervention, 5 control) were collected for 12 months prior and 13 months after intervention introduction. We categorized antibiotic change events (ACEs) as: (1) changes in dose, frequency, or route for the same antibiotic, (2) change to another antibiotic with different spectrum, and (3) early discontinuation (stopped after 2 days or less). Modifications considered to be routine (e.g., Azithromycin dose reduction from 500 to 250 mg) were not considered a meaningful ACE. Frequency of ACEs both overall and by type were compared using a difference in difference (DID) approach. Results Of 2647 NH initiated antibiotic events, 376 (14.2%) were modified over the study period. The most common type of modification was a change in spectrum (n = 241, 64.1%) followed by early discontinuation of the antibiotic (n = 118, 31.4%). The difference in ACEs before and after the intervention as well as DID estimates are detailed in the Table. Conclusion The antibiotic stewardship intervention did not impact total ACEs but did appear to increase the frequency of discontinuation ACEs. An inability to capture data on shortening ACEs (e.g., reducing a treatment course from 14 to 7 days) was a limitation of this study. Additional research on how to foster more frequent and effective antibiotic timeouts in NHs is needed. Disclosures All authors: No reported disclosures.

Antibiotic stewardship crucial in NICU, CF patients

2013 ◽  
Vol 47 (1) ◽  
pp. 9
Author(s):  
DOUG BRUNK
Keyword(s):  
Antibiotic Stewardship

Krankenhaushygiene - Antibiotic Stewardship

2017 ◽  
Vol 22 (12) ◽  
pp. 64-66
Author(s):  
Peter Walger
Keyword(s):  
Antibiotic Stewardship ◽  
Antibiotic Stewardship Abs

Hygienemaßnahmen sind wichtig, richtig und unbedingt notwendig. Aber sie sind nur eine Seite der Medaille, um Infektionen zu verhindern. Die andere Seite ist die optimale Therapie von Infektionen. Unter dem Strategiebegriff „Antibiotic Stewardship“ (ABS) gibt es inzwischen zahlreiche Leitlinien und Empfehlungen für einen sinnvollen Antibiotikagebrauch. Eine Klinik ist gut beraten, in ABS zu investieren, denn die positiven Effekte auf das klinische und ökonomische Outcome sind nicht von der Hand zu weisen.

A step towards antibiotic stewardship -Evaluation of antimicrobial usage among patients of rural teaching hospital of Telangana

2019 ◽  
Vol 12 (3) ◽  
pp. 41-45
Author(s):  
Gitanjali Kailas Badave ◽  
◽  
Priyanka Puneriya ◽  
Keyword(s):  
Teaching Hospital ◽  
Antibiotic Stewardship ◽  
Antimicrobial Usage ◽  
Rural Teaching

scholarly journals Penicillin Allergy Skin Testing as an Antibiotic Stewardship Intervention in Hematopoietic Cell Transplant Recipients

2017 ◽  
Vol 4 (suppl_1) ◽  
pp. S266-S267 ◽  
Author(s):  
Christopher Kovacs ◽  
Vasilios Athans ◽  
David Lang ◽  
Ronald Sobecks ◽  
Lisa Rybicki ◽  
...  
Keyword(s):  
Antibiotic Stewardship ◽  
Skin Testing ◽  
Hematopoietic Cell ◽  
Penicillin Allergy ◽  
Cell Transplant ◽  
Transplant Recipients ◽  
Hematopoietic Cell Transplant ◽  
Allergy Skin Testing
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