Line‐field confocal optical coherence tomography: a novel, non‐invasive imaging technique for a rapid, in‐vivo diagnosis of herpes infection of the skin

Optical coherence tomography (OCT) is a non-invasive imaging technique widely used in ophthalmology. The presence of speckle affects the quality of OCT images. Despeckling is necessary to improve its visual quality, and it is an integral part of software packages used for the computerized analysis of OCT. Even though a few methods for despeckling OCT are available in the literature, a cross-comparison of their performance is not known to be available. In this chapter, the techniques available in the literature for despeckling the OCT images have been identified. The results of the despeckling algorithms are compared both qualitatively and quantitatively by concerning the noise suppression capability and feature preservation. Among the available techniques, iterative adaptive unbiased (IAUB) filter is found to be superior as far as its performance regarding despeckling on retinal OCT images.

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Line‐field confocal optical coherence tomography for the in‐vivo real‐time diagnosis of different stages of keratinocyte skin cancer: a preliminary study

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/jdv.17603 ◽

2021 ◽

Author(s):

Cristel Ruini ◽

Sandra Schuh ◽

Charlotte Gust ◽

Benjamin Kendziora ◽

Leonie Frommherz ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Skin Cancer ◽

Real Time ◽

Optical Coherence ◽

Line Field ◽

Preliminary Study ◽

Time Diagnosis

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Optical coherence tomography imaging of oral mucosa bullous diseases: a preliminary study

Dentomaxillofacial Radiology ◽

10.1259/dmfr.20190071 ◽

2020 ◽

Vol 49 (2) ◽

pp. 20190071

Author(s):

Dario Di Stasio ◽

Dorina Lauritano ◽

Francesca Loffredo ◽

Enrica Gentile ◽

Fedora Della Vella ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Oral Mucosa ◽

Statistical Power ◽

Pemphigus Vulgaris ◽

Invasive Technique ◽

Optical Coherence ◽

Non Invasive ◽

Bullous Diseases ◽

Subepithelial Layer

Objectives: Optical coherence tomography (OCT) is a non-invasive technique based on optical imaging with a micrometre resolution. The purpose of this study is to investigate the potential role of OCT in evaluating oral mucosa bullous diseases. Methods: two patients with bullous pemphigoid (BP) and one patient with pemphigus vulgaris (PV) were examined and images of their oral lesions were performed using OCT. Results: In OCT images, the BP blister has a clearly different morphology from the PV one compared to the blistering level. Conclusion: This exploratory study suggests that the OCT is able to distinguish epithelial and subepithelial layer in vivo images of healthy oral mucosa from those with bullous diseases, assisting the clinicians in differential diagnosis.The presented data are in accordance with the scientific literature, although a wider pool of cases is needed to increase statistical power. Histological examination and immunofluorescence methods remain the gold standard for the diagnosis of oral bullous diseases. In this context, the OCT can provide the clinician with a valuable aid both as an additional diagnostic tool and in the follow up of the disease.

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