Major response to adalimumab in patient with Sweet syndrome associated to an acquired cutis laxa

Author(s):  
Pauline Rosier ◽  
Alban Deroux ◽  
Aude Beyens ◽  
Bert Callewaert ◽  
Marie‐Therese Leccia
2021 ◽  
Vol 22 (3) ◽  
pp. 254
Author(s):  
SeetharampuraRamamurthy Radhika ◽  
GowrappalaShanmukhappa Asha ◽  
Kanathur Shilpa ◽  
Heera Ramesh
Keyword(s):  

2019 ◽  
Vol 47 (2) ◽  
pp. 146-149
Author(s):  
Ashish Jagati ◽  
Shivank Shrivastava ◽  
Bhavna Baghela ◽  
Pooja Agarwal ◽  
Siddhartha Saikia

1995 ◽  
Vol 14 (2) ◽  
pp. 173-178 ◽  
Author(s):  
W.P. Daniel Su ◽  
Debra L. Fett ◽  
Lawrence E. Gibson ◽  
Mark R. Pittelkow

Author(s):  
Kelly E Flanagan ◽  
Steven Krueger ◽  
Shinya Amano ◽  
Amanda Auerbach ◽  
Jessica St. John ◽  
...  
Keyword(s):  

2021 ◽  
pp. 004947552199849
Author(s):  
Prakriti Shukla ◽  
Kiran Preet Malhotra ◽  
Parul Verma ◽  
Swastika Suvirya ◽  
Abir Saraswat ◽  
...  

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley–Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. We found 17/386 leprosy patients with non-neuropathic ulcers. We describe three causes – spontaneous cutaneous ulceration in lepromatous leprosy (one nodular and one diffuse), lepra reactions (five patients with type 1; nine with type 2, further categorised into ulcerated Sweet syndrome-like who also had pseudoepitheliomatous hyperplasia, pustulo-necrotic and necrotic erythema nodosum leprosum) and Lucio phenomenon (one patient). Our series draws attention towards the different faces of non-neuropathic ulcers in leprosy, including some atypical and novel presentations.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jila Nasirzade ◽  
Zahra Kargarpour ◽  
Goran Mitulović ◽  
Franz Josef Strauss ◽  
Layla Panahipour ◽  
...  

AbstractParticulate autologous tooth roots are increasingly used for alveolar bone augmentation; however, the proteomic profile of acid dentin lysate and the respective cellular response have not been investigated. Here we show that TGF-β1 is among the 226 proteins of acid dentin lysate (ADL) prepared from porcine teeth. RNA sequencing identified 231 strongly regulated genes when gingival fibroblasts were exposed to ADL. Out of these genes, about one third required activation of the TGF-β receptor type I kinase including interleukin 11 (IL11) and NADPH oxidase 4 (NOX4). Reverse transcription-quantitative polymerase chain reaction and immunoassay confirmed the TGF-β-dependent expression of IL11 and NOX4. The activation of canonical TGF-β signaling by ADL was further confirmed by the phosphorylation of Smad3 and translocation of Smad2/3, using Western blot and immunofluorescence staining, respectively. Finally, we showed that TGF-β activity released from dentin by acid lysis adsorbs to titanium and collagen membranes. These findings suggest that dentin particles are a rich source of TGF-β causing a major response of gingival fibroblasts.


Author(s):  
Neera R. Nathan ◽  
Daniel M. O'Connor ◽  
Jonathan J. Lee ◽  
Kristine M. Cornejo ◽  
Jennifer K. Tan ◽  
...  

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