Effect of ethanol and aqueous extracts of seed pod of
            Copaifera salikounda
            (Heckel) on complete Freund's adjuvant‐induced rheumatoid arthritis in rats

Introduction: Cassia fistula has anti-inflammatory activity. Rheumatoid arthritis (RA) is an autoimmune disease, causing inflammation and disability of the affected joints. It is mostly treated symptomatically with NSAIDs, which themselves have a lot of adverse effects. In this study the anti-arthritic effect of Cassia fistula versus naproxen has been observed radiologically. Aims & Objectives: The present study was radiological analysis of anti-arthritic effect of Cassia fistula compared to naproxen in Complete Freund’s Adjuvant (CFA) induced rat model of rheumatoid arthritis. Place and duration of study: This study was conducted at the Animal House of University of Veterinary and Animal Sciences, Lahore for a period of three months. Material & Methods: The study was carried out on 96 male rats divided into 12 groups of 8 rats each. Single 0.2ml dose of Complete Freund’s Adjuvant (CFA) was injected in the right hind paw of each rat in all groups except Group 1 (negative control). Group 2 was positive control. The prophylactic (3-7) and therapeutic (8- 12) groups were given naproxen (25mg/kg), anthraquinone extract (250 &500mg/kg) or methanolic extract (250 & 500mg/kg) of Cassia fistula orally BD on days 1,2 &3 (first dose preceding CFA injection by 30 minutes) and on days 9,10 &11 for therapeutic groups respectively. On day 15, x-rays of right ankle joints of all groups were taken as a confirmatory investigation on the final status of the arthritis. Results: Our results showed both anthraquinone and methanolic extracts of Cassia fistula have dose dependent (500˃250mg/dl) prophylactic and therapeutic anti-arthritic potential albeit lesser than naproxen 25mg/kg, to reduce the swelling of hind paw and deformity of interphalangeal joints on radiological examination. Conclusion: The efficacy of Cassia fistula makes it a potential weaker candidate to naproxen in prevention and treatment of rheumatoid arthritis.

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Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats

Journal of Toxicology ◽

10.1155/2019/7898914 ◽

2019 ◽

Vol 2019 ◽

pp. 1-11 ◽

Cited By ~ 1

Author(s):

Srinivasa Reddy Jitta ◽

Prasanthi Daram ◽

Karthik Gourishetti ◽

C. S. Misra ◽

Picheswara Rao Polu ◽

...

Keyword(s):

Wistar Rats ◽

Complete Freund’S Adjuvant ◽

Inflammatory Activity ◽

Aqueous Extracts ◽

Adjuvant Induced Arthritis ◽

Freund’S Adjuvant ◽

Complete Freund's Adjuvant ◽

Freund's Adjuvant ◽

Anti Inflammatory

Terminalia tomentosa bark belongs to the family Combretaceae. The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea. Phytochemical investigation of T. tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins. The plant has not been investigated for its anti-inflammatory and antiarthritic activity. The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity. Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods. In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats. Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models. We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats. This study shows that the T. tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also. Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T. tomentosa.

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Anti-Inflammatory Effects of Step Electrical Stimulation on Complete Freund’s Adjuvant (CFA) Induced Rheumatoid Arthritis Rats

Journal of Nanoscience and Nanotechnology ◽

10.1166/jnn.2019.17077 ◽

2019 ◽

Vol 19 (10) ◽

pp. 6546-6553 ◽

Cited By ~ 1

Author(s):

Min-Seok Kim ◽

Seung-Ho Lee ◽

Ji-Hye Kim ◽

Ok-Kyun Kim ◽

Ah-Ran Yu ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Electrical Stimulation ◽

Complete Freund’S Adjuvant ◽

Freund’S Adjuvant ◽

Complete Freund's Adjuvant ◽

Freund's Adjuvant ◽

Anti Inflammatory

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Anti-inflammatory Activity of Taiwan Folk Medicine "Ham-Hong-Chho" in Rats

The American Journal of Chinese Medicine ◽

10.1142/s0192415x95000328 ◽

1995 ◽

Vol 23 (03n04) ◽

pp. 273-278 ◽

Cited By ~ 16

Author(s):

Hwa-Woei Chih ◽

Chun-Ching Lin ◽

Kung-Sheng Tang

Keyword(s):

Folk Medicine ◽

Chronic Arthritis ◽

Complete Freund’S Adjuvant ◽

Aqueous Extracts ◽

Paw Edema ◽

Bidens Pilosa ◽

Freund’S Adjuvant ◽

Complete Freund's Adjuvant ◽

Freund's Adjuvant ◽

Anti Inflammatory

"Ham-Hong-Chho" is a folk medicine in Taiwan, derived from the entire plants of Bidens pilosa L. var. minor (Blume) Sherff (Compositae), B. pilosa L. and B. chilensis DC. The anti-inflammatory effect of aqueous extracts of the three plants against paw edema induced by carrageenan and chronic arthritis induced by complete Freund's adjuvant were determined in rats. The results indicated that paw edema induced by carrageenan was significantly decreased by treatment with aqueous extracts (150 or 300 mg/kg) of all three plants ( p < 0.05) and that the effect of Bidens pilosa var. minor was the most potent. However, only extracts (500 mg/kg) of B. pilosa L. var. minor and B.pilosa L. significantly decreased the paw edema induced by complete Freund's adjuvant ( p < 0.05).

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