scholarly journals Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma

2015 ◽  
Vol 30 ◽  
pp. 78-84 ◽  
Author(s):  
Ilona Kohler ◽  
Peter Bronsert ◽  
Sylvia Timme ◽  
Martin Werner ◽  
Thomas Brabletz ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Detailed Analysis ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Budding ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Mesenchymal Transition

Su1825 Detailed Analysis of EMT and Tumor Budding Identifies Predictors of Long Term Survival in Pancreatic Ductal Adenocarcinoma

2014 ◽  
Vol 146 (5) ◽  
pp. S-1046
Author(s):  
Peter Bronsert ◽  
Ilona Kohler ◽  
Dirk Bausch ◽  
Tobias Keck ◽  
Martin Werner ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Detailed Analysis ◽  
Tumor Budding ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Vascular resection for locally advanced pancreatic ductal adenocarcinoma: analysis of long-term outcomes from a single-centre series

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Claudio F. Feo ◽  
Giulia Deiana ◽  
Chiara Ninniri ◽  
Giuseppe Cherchi ◽  
Paola Crivelli ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Locally Advanced ◽  
Operating Time ◽  
Vascular Resection ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Aggressive Approach ◽  
Long Term Survival ◽  
Cox Regression Analysis

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with poor prognosis. Radical surgery is the best option for cure and, nowadays, it is performed by many surgeons also in cases of vascular infiltration. Whether this aggressive approach to a locally advanced PDAC produces a survival benefit is under debate. Most data in the literature come from retrospective comparative studies; therefore, it is still unclear if such an extensive surgery for an advanced cancer is justified. Methods A retrospective review of patients with PDAC treated at our institution over a 12-year period was performed. Data concerning patients’ characteristics, operative details, postoperative course, and long-term survival were retrieved from prospective databases and analysed. Factors associated with poor survival were assessed via Cox regression analysis. Results A total of 173 patients with PDAC were included in the analysis, 41 subjects underwent pancreatectomy with vascular resection for locally advanced disease, and in 132 patients, only a pancreatic resection was undertaken. Demographics, major comorbidities, and tumour characteristics were similar between the two groups. Length of surgery (P=0.0006), intraoperative blood transfusions (P<0.0001), and overall complications (P<0.0001) were significantly higher in the vascular resection group. Length of hospital stay (P=0.684) and 90-day mortality (P=0.575) were comparable between groups. Overall median survival (P= 0.717) and survival rates at 1, 3, and 5 years (P=0.964, P=0.500, and P=0.445, respectively) did not differ significantly between groups. Age ≥70 years and postoperative complications were independent predictors of lower survival. Conclusions Our study confirms that pancreatectomy with vascular resection for a locally advanced PDAC is a complex operation associated with a significant longer operating time that may increase morbidity; however, in selected patients, R0 margins can be obtained with an acceptable long-term survival rate. Older patients are less likely to benefit from surgery.

scholarly journals Survival and quality of life following pancreaticoduodenectomy for pancreatic ductal adenocarcinoma

2021 ◽  
Vol 6 (2) ◽  
Keyword(s):  
Quality Of Life ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Short Review ◽  
Mortality Rates ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Dismal Prognosis

Pancreatic ductal adenocarcinoma (PDAC) most commonly affects the head of the pancreas. This condition has a dismal prognosis. Patients with early disease may be candidates for pancreaticoduodenectomy (PD). This is a high-risk operation which is associated with considerable morbidity. Whilst perioperative mortality rates have fallen in recent times, the risk remains significant and long-term survival is poor, even in those who make an uncomplicated recovery. Furthermore, PD is known to affect quality of life (QoL) negatively. Most studies suggest it takes up to six months before a patient’s QoL returns to baseline. This is a considerable amount of time for a patient who is unlikely to achieve long-term survival. This short review discusses the recent literature surrounding mortality rates, long-term survival and QoL following PD for PDAC. A comprehensive understanding of these topics will allow clinicians and patients to consider the risks and benefits before surgical resection is considered.

scholarly journals Factors affecting long-term survival after surgical resection of pancreatic ductal adenocarcinoma

2011 ◽  
Vol 81 (6) ◽  
pp. 394 ◽  
Author(s):  
Kyoung Won Yoon ◽  
Jin Seok Heo ◽  
Dong Wook Choi ◽  
Seoung Ho Choi
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Surgical Resection ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Factors Affecting

Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study

2015 ◽  
Vol 22 (S3) ◽  
pp. 1238-1246 ◽  
Author(s):  
Kenichiro Uemura ◽  
Yoshiaki Murakami ◽  
Sohei Satoi ◽  
Masayuki Sho ◽  
Fuyuhiko Motoi ◽  
...  
Keyword(s):  
Observational Study ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Biliary Drainage ◽  
Preoperative Biliary Drainage ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Multicenter Observational Study

Patients with resected, histologically re-confirmed pancreatic ductal adenocarcinoma (PDAC) can achieve long-term survival despite T3 tumour or nodal involvement. The Finnish Register Study 2000–2013

Pancreatology ◽  
2017 ◽  
Vol 17 (5) ◽  
pp. 822-826 ◽  
Author(s):  
Reea Ahola ◽  
Antti Siiki ◽  
Kaija Vasama ◽  
Martine Vornanen ◽  
Juhani Sand ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Register Study ◽  
Ductal Adenocarcinoma ◽  
Nodal Involvement ◽  
Term Survival ◽  
Long Term Survival

scholarly journals Long-Term Survival After Curative Resection for Pancreatic Ductal Adenocarcinoma

1996 ◽  
Vol 223 (3) ◽  
pp. 273-279 ◽  
Author(s):  
Kevin C. Conlon ◽  
David S. Klimstra ◽  
Murray F. Brennan
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Curative Resection ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival

Tumor budding is a prognostic factor linked to epithelial mesenchymal transition in pancreatic ductal adenocarcinoma. Study report and literature review

Pancreatology ◽  
2018 ◽  
Vol 18 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Ezzeddine Chouat ◽  
Alia Zehani ◽  
Ines Chelly ◽  
Manel Njima ◽  
Houcine Maghrebi ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Literature Review ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Tumor Budding ◽  
Ductal Adenocarcinoma ◽  
Mesenchymal Transition ◽  
Study Report

scholarly journals Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma

2012 ◽  
Vol 13 (10) ◽  
pp. 899-907 ◽  
Author(s):  
Ru Chen ◽  
Sheng Pan ◽  
NIki A. Ottenhof ◽  
Roeland F. de Wilde ◽  
Christopher L. Wolfgang ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Ductal Adenocarcinoma ◽  
Term Survival ◽  
Long Term Survival
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