Effectiveness of casein phosphopeptide‐amorphous calcium phosphate‐containing products in the prevention and treatment of white spot lesions in orthodontic patients: A systematic review

Objective: The prevalence of enamel demineralization among patients after orthodontic treatment is about 50%, which begins with the formation of white spot lesions. The presence of these lesions causes esthetic problems. The aim of this study was to quantify the color changes in post-debonding white spot lesions after microabrasion technique with fluoride and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) application.Materials and Methods: This study used 42 first premolar teeth that had been extracted, then were soaked for 96 h in a demineralization solution (pH 4, 37°C) to form an artificial white spot lesions. Samples were randomly divided into three treatment groups (n=14): (A) Microabrasion technique only; (B) microabrasion technique with 10% CPP-ACP paste application; and (C) microabrasion technique with 1.23% APF gel application. All groups were assigned to pH cycling for 10 days. The color change was determined using spectrophotometer at 3 different time points, which were measured before and after production of the artificial white spot lesions, and after the artificial white spot lesions were treated.Results: This study showed that there was a significant difference in the color of the artificial white spot lesions after microabrasion technique with CPP-ACP application.Conclusion: Microabrasion technique with CPP-ACP application was giving better result in changing the color of white spot lesions than only microabrasion technique and microabrasion technique with fluoride application.

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Efficacy of erbium-doped yttrium aluminum garnet laser with casein phosphopeptide amorphous calcium phosphate with and without fluoride for remineralization of white spot lesions around orthodontic brackets

European Journal of Dentistry ◽

10.4103/ejd.ejd_265_17 ◽

2018 ◽

Vol 12 (02) ◽

pp. 210-216 ◽

Cited By ~ 1

Author(s):

Sogra Yassaei ◽

Hossein Aghili ◽

Neda Shahraki ◽

Isa Safari

Keyword(s):

Calcium Phosphate ◽

Amorphous Calcium Phosphate ◽

Yttrium Aluminum Garnet ◽

White Spot ◽

White Spot Lesions ◽

Volume Percentage ◽

Erbium Doped ◽

Yttrium Aluminum ◽

Casein Phosphopeptide ◽

Mineral Loss

ABSTRACT Objective: This study aimed to assess the efficacy of erbium-doped yttrium aluminum garnet (Er:YAG) laser, pastes containing casein phosphopeptide amorphous calcium phosphate (CPP-ACP) with and without fluoride and their combination for prevention of white spot lesions in the enamel. Materials and Methods: This in vitro experimental study was conducted on 90 extracted sound premolars. The teeth were then randomly divided into six groups of 15: (1) Control, (2) laser, (3) CPP-ACP with fluoride (GC MI Paste, RecaldentTM 900 ppm as NaF), (4) CPP-ACP without fluoride (GC Tooth Mousse RecaldentTM), (5) laser + CPP-ACP with fluoride, and (6) laser + CPP-ACP without fluoride. In each group, enamel surface was exposed to the remineralizing agent. The teeth were then subjected to pH cycling for 14 days. The teeth were then sectioned, polished, and underwent cross-sectional microhardness testing at 20–160 μ depth quantitatively. Using the Simpson's rule, the amount of mineral loss was calculated in each group. Statistical Analysis Used: ANOVA was used for the comparisons, and Tukey's test was applied for pairwise comparisons. Results: The highest mean volume percentage of microhardness at 20–60 μ depth belonged to the group laser + CPP-ACP with fluoride and the lowest belonged to the control group (P = 0.001). The differences were not significant at 80-120 μ depth (P > 0.05). These finding are confirmed according to △Z (mineral loss). Conclusion: Based on these results, Er: YAG laser was able to decrease demineralization and was a potential alternative to preventive dentistry and was more effective when combined with CPP-ACP products.

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REMINERALIZATION POTENTIAL OF FUNCTIONALIZED TRICALCIUM PHOSPHATE VERSUS CASEIN PHOSPHOPEPTIDE- AMORPHOUS CALCIUM PHOSPHATE IN CARIES WHITE SPOT LESIONS “A RANDOMIZED CLINICAL TRIAL”

Egyptian Dental Journal ◽

10.21608/edj.2021.62669.1498 ◽

2021 ◽

Vol 67 (3) ◽

pp. 2613-2622

Author(s):

Donia Galila ◽

mohamed khairy ◽

Shereen Ibrahim

Keyword(s):

Clinical Trial ◽

Calcium Phosphate ◽

Randomized Clinical Trial ◽

Tricalcium Phosphate ◽

Amorphous Calcium Phosphate ◽

White Spot ◽

White Spot Lesions ◽

Casein Phosphopeptide

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Does Casein Phosphopeptid Amorphous Calcium Phosphate Provide Remineralization on White Spot Lesions and Inhibition of Streptococcus mutans?

Journal of Clinical Pediatric Dentistry ◽

10.17796/jcpd.38.4.b4q401v6m4818215 ◽

2014 ◽

Vol 38 (4) ◽

pp. 302-306 ◽

Cited By ~ 5

Author(s):

Arzu Aykut-Yetkiner ◽

Nazan Kara ◽

Mustafa Ateş ◽

Nazan Ersin ◽

Fahinur Ertuğrul

Keyword(s):

Calcium Phosphate ◽

Streptococcus Mutans ◽

Amorphous Calcium Phosphate ◽

Saliva Sample ◽

Test Group ◽

White Spot ◽

Control Group ◽

White Spot Lesions ◽

Sample Collection ◽

Significant Difference

Objective: The aim of this study was to evaluate the remineralization effect of Casein Phosphopeptid Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSL) and its inhibitory effect on Streptococcus mutans colonization. Study design: The study group consisted of 60 children exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: a test group of using CPP-ACP cream (Tooth Mousse, GC Europe N.V., Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-months. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva sample collection was repeated. Wilcoxon Signed Ranks Test was used for statistical analysis. Results: DIAGNOdent measurements were increased by time (p=0.002) in control group and no statistically significant difference (p=0.217) was found in test group by the 3-month period. In both groups, the mutans counts were decreased in 3-month experimental period. Conclusions: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however longer observation is recommended to confirm whether the greater change in WSLs is maintained.

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BOND FAILURE RATE OF AMORPHOUS CALCIUM PHOSPHATE CONTAINING (AEGIS ORTHO) AND FLUORIDE RELEASING (TRANSBOND PLUS COLOUR CHANGE) ORTHODONTIC ADHESIVES-A RANDOMIZED CLINICAL TRIAL

Journal of Indian Dental Association ◽

10.33882/jida.13.25277 ◽

2019 ◽

Author(s):

Shyamala Naidu ◽

Anand Suresh

Keyword(s):

Calcium Phosphate ◽

Failure Rate ◽

Amorphous Calcium Phosphate ◽

Age Groups ◽

Colour Change ◽

White Spot ◽

Rank Test ◽

White Spot Lesions ◽

Bond Failure ◽

Kaplan Meier

Background: The aim of the study was to compare the survival rate of brackets bonded with amorphous calcium phosphate containing adhesive and fluoride releasing orthodontic adhesive over 6 months period. White spot lesions were also evaluated prior to bonding, 3 months and 6 months from the date of bonding. Methods: Thirty six orthodontic patients were randomly divided into two equal groups using split mouth design. 592 brackets were bonded up to the premolars with either Aegis Ortho or Transbond Colour Change(TPCCA). Bracket failure rate and survival distribution were evaluated and compared using Kaplan- meier analysis and Log rank test with respect to adhesives, dental arches, segments , tooth types, gender and age groups. White spot lesion was assessed using WSL index. Results: There was no significant difference between the failure rate of Aegis Ortho(3.0%) and TPCCA(1.4%). Kaplan Meier analysis, Log rank test showed that the difference in the overall failure rate and survival time between the arches, gender, and different age groups were not statistically significant. Both adhesives had a high bond failure rate in the posterior segment especially in the premolar region. Three patients had white spot lesions in the upper premolar region bonded with Aegis ortho. Conclusion: Both Aegis ortho and Transbond plus colour change adhesive with a low bond failure rate can be used as an alternative orthodontic adhesive. Key words : bond failure, amorphous calcium phosphate, transbond colour change adhesive, white spot lesions.

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