The genetic composition of populations of cynomolgus macaques (Macaca fascicularis
) used in biomedical research

AbstractLong-tailed macaques are highly social primates that are commonly used in biomedical research as animal models. The aim of this study was to evaluate the effects of different kinds of enrichment on the behaviour and faecal cortisol metabolite (FCM) level in a colony of ex-laboratory long-tailed macaques during a programme of rehabilitation. The research was carried out in three periods, divided into two sessions each. Every period was composed of one control session (SC) and one session characterised by one type of enrichment: feeding enrichment (FE), manipulative enrichment (ME), and the last session during which manipulative and feeding enrichment were provided every day but in a mixed way (MIX). The results showed that manipulative and mixed enrichments caused positive changes to the activity budget of the colony, with a decrease in abnormal behaviour rates and an increase in play compared with control sessions. The rate of affiliative behaviours and low rate of aggression were probably because the group was composed mostly of females and it was stable, with a well-defined hierarchy. The research underlines the importance of a well-studied enrichment programme for the welfare of captive animals, which should exploit species-specific motivations.

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Experimental Infection of Cynomolgus Macaques (Macaca fascicularis) with Aerosolized Monkeypox Virus

PLoS ONE ◽

10.1371/journal.pone.0012880 ◽

2010 ◽

Vol 5 (9) ◽

pp. e12880 ◽

Cited By ~ 31

Author(s):

Aysegul Nalca ◽

Virginia A. Livingston ◽

Nicole L. Garza ◽

Elizabeth E. Zumbrun ◽

Ondraya M. Frick ◽

...

Keyword(s):

Experimental Infection ◽

Macaca Fascicularis ◽

Monkeypox Virus ◽

Cynomolgus Macaques

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Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney

Journal of Diabetes & Metabolism ◽

10.4172/2155-6156.1000334 ◽

2014 ◽

Vol 05 (02) ◽

Author(s):

Wubin Qian Fenglai Du

Keyword(s):

Transcriptome Analysis ◽

Metabolic Disorder ◽

Macaca Fascicularis ◽

Cynomolgus Macaques

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Ultrasound-guided, Transabdominal, Intrauterine Artificial Insemination for Cynomolgus Macaques (Macaca fascicularis) Based on Estimated Timing of Ovulation

Journal of the American Association for Laboratory Animal Science ◽

10.30802/aalas-jaalas-20-000038 ◽

2021 ◽

Vol 60 (2) ◽

pp. 125-132

Author(s):

Nobuhiro Shimozawa ◽

Naohide Ageyama ◽

Shunya Nakayama ◽

Hiroshi Koie ◽

Yasuhiro Yasutomi

Keyword(s):

Artificial Insemination ◽

Macaca Fascicularis ◽

Rhesus Macaques ◽

Complex Structure ◽

Pregnancy Rates ◽

Cervical Canal ◽

Ultrasound Guided ◽

Cynomolgus Macaques

Intrauterine sperm injection for artificial insemination is difficult in cynomolgus macaques (Macaca fascicularis) and rhesus macaques (M. mulatta) due to the complex structure of the cervical canal, which differs from that of humans. Despite the availability of several artificial insemination methods for macaques, pregnancy rates are inconsistent, and details regarding ovulation are unclear, thus warranting more effective methods. Therefore, we developed an effective, ultrasound-guided, transabdominal intrauterine artificial insemination method for cynomolgus macaques that involves timing sperm injection to coincide with the periovulation phase estimated according to rapid hormone measurement. We performed our intrauterine artificial insemination on 6 female macaques; 4 of the 5 animals that were predicted to have ovulated soon after insemination became pregnant, whereas the 1 macaque that was predicted not to have ovulated did not. Furthermore, we saw no evidence of injury, such as a conspicuous needle hole or bleeding on the surface of or inside the uterus, nor did our method result in any abnormalities in the mothers or their offspring. Thus, our ultrasound-guided, transabdominal, intrauterine artificial insemination method is rapid, safe, and effective in cynomolgus macaques.

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