Neuropeptide Y suppresses thermogenic and cardiovascular sympathetic nerve activity via Y1 receptors in the paraventricular nucleus and dorsomedial hypothalamus

2021 ◽  
Author(s):  
Zhigang Shi ◽  
Alyssa C. Bonillas ◽  
Jennifer Wong ◽  
Stephanie L. Padilla ◽  
Virginia L. Brooks
Keyword(s):  
Neuropeptide Y ◽  
Paraventricular Nucleus ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Dorsomedial Hypothalamus ◽  
Y1 Receptors

scholarly journals Insulin increases sympathetic nerve activity in part by suppression of tonic inhibitory neuropeptide Y inputs into the paraventricular nucleus in female rats

2016 ◽  
Vol 311 (1) ◽  
pp. R97-R103 ◽  
Author(s):  
Priscila A. Cassaglia ◽  
Zhigang Shi ◽  
Virginia L. Brooks
Keyword(s):  
Neuropeptide Y ◽  
Paraventricular Nucleus ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Female Rats ◽  
Nerve Activity ◽  
Baroreflex Control ◽  
Melanocyte Stimulating Hormone ◽  
Y1 Receptors ◽  
Type 3

Following binding to receptors in the arcuate nucleus (ArcN), insulin increases sympathetic nerve activity (SNA) and baroreflex control of SNA via a pathway that includes the paraventricular nucleus of the hypothalamus (PVN). Previous studies in males indicate that the sympathoexcitatory response is mediated by α-melanocyte stimulating hormone (α-MSH), which binds to PVN melanocortin type 3/4 receptors (MC3/4R). The present study was conducted in α-chloralose-anesthetized female rats to test the hypothesis that suppression of inhibitory neuropeptide Y (NPY) inputs to the PVN is also involved. In support of this, blockade of PVN NPY Y1 receptors with BIBO 3304 (NPY1x), ArcN insulin nanoinjections, and PVN NPY1x followed by ArcN insulin each increased lumbar SNA (LSNA) and its baroreflex regulation similarly. Moreover, prior PVN injections of NPY blocked the sympathoexcitatory effects of ArcN insulin. Finally, PVN nanoinjections of the MC3/4R inhibitor SHU9119 prevented both the acute (15 min) and longer, more slowly developing (60 min), increases in LSNA in response to ArcN insulin. In conclusion, in females, ArcN insulin increases LSNA, in part, by suppressing tonic PVN NPY inhibition, which unmasks excitatory α-MSH drive of LSNA. Moreover, the steadily increasing rise in LSNA induced by ArcN insulin is also dependent on PVN MC3/4R.

scholarly journals Neuropeptide Y acts in the paraventricular nucleus to suppress sympathetic nerve activity and its baroreflex regulation

2014 ◽  
Vol 592 (7) ◽  
pp. 1655-1675 ◽  
Author(s):  
Priscila A. Cassaglia ◽  
Zhigang Shi ◽  
Baoxin Li ◽  
Wagner L. Reis ◽  
Nicholas M. Clute-Reinig ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Paraventricular Nucleus ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity

Leptin Increases Sympathetic Nerve Activity by Acting in the Dorsomedial Hypothalamus of Leptin Resistant Mice

2011 ◽  
pp. P2-291-P2-291
Author(s):  
Pablo Jose Enriori ◽  
Stephanie E Simonds ◽  
Puspha Sinnayah ◽  
Cecilia Garcia Rudaz ◽  
Russell D Brown ◽  
...  
Keyword(s):  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Nerve Activity ◽  
Dorsomedial Hypothalamus

scholarly journals Author response: Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus

2020 ◽  
Author(s):  
Zhigang Shi ◽  
Nicole E Pelletier ◽  
Jennifer Wong ◽  
Baoxin Li ◽  
Andrei D Sdrulla ◽  
...  
Keyword(s):  
Paraventricular Nucleus ◽  
Sympathetic Nerve ◽  
Sympathetic Nerve Activity ◽  
Author Response ◽  
Nerve Activity
Sign in / Sign up

Export Citation Format

Share Document