Factors Influencing Parents’ Decision to Donate Their Healthy Infant's DNA for Minimal-Risk Genetic Research

2014 ◽  
Vol 46 (6) ◽  
pp. 398-407 ◽  
Author(s):  
Linda A. Hatfield ◽  
Margaret M. Pearce
2009 ◽  
Vol 0 (0) ◽  
pp. 090108090224061
Author(s):  
Mett Marri Laegsgaard ◽  
Ann Suhl Kristensen ◽  
Ole Mors

2009 ◽  
Vol 4 (1) ◽  
pp. 64
Author(s):  
Donna T Chen ◽  
James F Meschia ◽  
Bradford B Worrall ◽  
◽  
◽  
...  

Continued clinical and translational research is necessary to address unmet clinical needs in stroke and cerebrovascular disease. Ethical and scientific challenges confront these research efforts. Genetic stroke research faces a number of specific challenges related to the legacy of genetic exceptionalism and the reality that stroke frequently impairs decision-making capacity. Maximising scientific rigour and protecting human subjects have frequently and often erroneously been cast as opposing efforts. In this article, we review the challenges facing stroke genetic research and propose potential approaches given the current state of guidance and regulations. We consider the rationale behind including those with decisional impairment and several options to allow participation of these individuals. Appropriate infrastructure and processes should be established to ensure that genetic information poses minimal risk to individuals, just as has been done to minimise physical risk in non-therapeutic research.


US Neurology ◽  
2009 ◽  
Vol 05 (01) ◽  
pp. 41 ◽  
Author(s):  
Donna T Chen ◽  
James F Meschia ◽  
Bradford B Worrall ◽  
◽  
◽  
...  

Continued clinical and translational research is necessary to address unmet clinical needs in stroke and cerebrovascular disease. Ethical and scientific challenges confront these research efforts. Genetic stroke research faces a number of specific challenges related to the legacy of genetic exceptionalism and the reality that stroke frequently impairs decision-making capacity. Maximizing scientific rigor and protecting human subjects have frequently and often erroneously been cast as opposing efforts. In this article, we review the challenges facing stroke genetic research and propose potential approaches given the current state of guidance and regulations. We consider the rationale behind including those with decisional impairment and several options to allow participation of these individuals. Appropriate infrastructure and processes should be established to ensure that genetic information poses minimal risk to individuals, just as has been done to minimize physical risk in non-therapeutic research.


10.1186/gm255 ◽  
2011 ◽  
Vol 3 (6) ◽  
pp. 39 ◽  
Author(s):  
David E Lanfear ◽  
Philip G Jones ◽  
Sharon Cresci ◽  
Fengming Tang ◽  
Saif S Rathore ◽  
...  

2018 ◽  
Vol 40 (2) ◽  
pp. 146 ◽  
Author(s):  
Rob Appleby ◽  
Jess Mackie ◽  
Bradley Smith ◽  
Lilia Bernede ◽  
Darryl Jones

Wild predators that attack people represent a significant challenge to the management authorities charged with conserving populations whilst minimising human safety risk. Fraser Island is home to an iconic population of dingoes (Canis dingo). However, conflict stemming from negative human–dingo interactions (incidents), some resulting in serious human injury and in one case, a fatality, is an ongoing concern. In an effort to highlight important factors influencing incident dynamics, we investigated the most serious incident reports gathered by the Queensland Parks and Wildlife Service for the period 2001–15. We found a consistent pattern of incidents peaking in March/April and also July, corresponding with dingo breeding and whelping seasons (respectively). Monthly vehicle permit numbers (a proxy for visitation) were not positively correlated with incident rates, except during the breeding season. Male dingoes, particularly subadult males, featured heavily in incidents. Despite the fatality being highly publicised and the advent of copious on-site warning messages and other management interventions, serious incidents continue to occur annually, including some involving children. This suggests that risks are either not always understood, or are otherwise being ignored. While our results demonstrate that dingoes generally pose minimal risk to humans, some risk remains, particularly where poorly supervised children are concerned.


2015 ◽  
Vol 31 (1) ◽  
pp. 11-15 ◽  
Author(s):  
David S. Wendler ◽  
Annette Rid

Author(s):  
Julie A. Martini ◽  
Robert H. Doremus

Tracy and Doremus have demonstrated chemical bonding between bone and hydroxylapatite with transmission electron microscopy. Now researchers ponder how to improve upon this bond in turn improving the life expectancy and biocompatibility of implantable orthopedic devices.This report focuses on a study of the- chemical influences on the interfacial integrity and strength. Pure hydroxylapatite (HAP), magnesium doped HAP, strontium doped HAP, bioglass and medical grade titanium cylinders were implanted into the tibial cortices of New Zealand white rabbits. After 12 weeks, the implants were retrieved for a scanning electron microscopy study coupled with energy dispersive spectroscopy.Following sacrifice and careful retrieval, the samples were dehydrated through a graduated series starting with 50% ethanol and continuing through 60, 70, 80, 90, 95, and 100% ethanol over a period of two days. The samples were embedded in LR White. Again a graduated series was used with solutions of 50, 75 and 100% LR White diluted in ethanol.


Author(s):  
Jennifer Tufts

Loud music and noisy hobbies are part of our cultural landscape. These activities can be enjoyed with minimal risk to hearing if a few commonsense guidelines are followed. Educating clients about risks and protective strategies will empower them to make informed decisions about their hearing health that best reflect their values and priorities. In this article, the author covers essential information to avoiding noise-induced hearing loss, writing in easily accessible language to better help clinicians convey this information to their clients.


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