Microneedling combined with platelet-rich plasma or trichloroacetic acid peeling for management of acne scarring: A split-face clinical and histologic comparison

2017 ◽  
Vol 17 (1) ◽  
pp. 73-83 ◽  
Author(s):  
Moetaz El-Domyati ◽  
Hossam Abdel-Wahab ◽  
Aliaa Hossam
Author(s):  
Manish Kumar Meena ◽  
Deepika Meena ◽  
Dilip Kachhawa ◽  
R D Mehta

Background: Post acne scarring is a consequence of abnormal resolution or wound healing following the damage that occurs in the sebaceous follicle during acne inflammation Methods: Interventional split face comparative prospective study was conduct at Department of Dermatology, Venereology and Leprology, S N Medical College and Attached Hospitals, Jodhpur. Results: After one month of 3rd treatment session, 84% patients stated that they were satisfied or very satisfied on the platelet-rich plasma side, while 7% patients stated this about the normal saline side (P = 0.18).The platelet-rich plasma side was found to have a better response than the control side and participants were more satisfied with the platelet-rich plasma side than the control side. Conclusion: In conclusion, PRP alone provides better overall clinical improvement. We suggest that PRP should be considered as a monotherapy therapeutic option in the management of acne scars. Keywords: PRP, Scar, Acne


QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M A Abdallah ◽  
C K T Gobrial ◽  
S G H Gomah

Abstract Background Acne scarring is often the primary concern of a patient with acne. Acne scarring can cause depression and is a risk factor for suicide. Patients feel their appearance interferes with their relationships and chances of future employment. Acne scars can be classified into 3 different types: atrophic, hypertrophic, or keloidal. Atrophic acne scars are the most common type. Atrophic acne scars are divided into three main types: ice pick, rolling and boxcar scars. Aim of the Work To compare the results of whole facial area versus Focal Acne Scar Treatment (FAST) by factional CO2 laser in a split face study. Patients and Methods The present study is a split face comparative study which included 20 adult patients with atrophic acne scars ranged from 18 to 44 years old of both sex. The study was approved by the Research Ethical Committee, Faculty of Medicine, Ain Shams University and fulfilled all the ethical aspects required in human research. All patients received full information about description of the procedure of treatment, possible side effects, photo documentation and they all provided written consent. Results Patients were asked to compare the pain, peeling and complications between the right and left sides post CO2 fractional treatment: pain was more at right side in 35% of cases and more at left side in 30% of cases and equal in the rest of cases, peeling was faster at the right side in 60% of cases, faster at the left side in 20% of cases and equal at the rest of cases, 4 of the patients had post inflammatory hyperpigmentation (1 patient at right side, 2 patients at left side and 1 patient at both sides), no other complications were recorded as secondary infection, scaring keloid and prolonged erythema. Conclusion We compared the results of whole facial area treatment in the right side of the face versus Focal Acne Scar Treatment (FAST) in the left side by factional CO2 laser. We discovered that there is a statistically highly significant relationship between the improvement of acne scars and treatment with fractional CO2 laser by the either techniques. Both techniques are preferable in treating acne scars in equal degree.


2019 ◽  
Vol 23 (2) ◽  
pp. 185-203 ◽  
Author(s):  
Aditya K. Gupta ◽  
Sarah G. Versteeg ◽  
Jeffrey Rapaport ◽  
Amelia K. Hausauer ◽  
Neil H. Shear ◽  
...  

As a promising alternative to traditional treatment, platelet-rich plasma (PRP) is being used to encourage hair growth through the release of growth factors and cytokines. In addition to hair restoration, PRP’s multifactorial capabilities can also be used to treat aging skin, facial scarring, and acne. The purpose of this review is to critically examine the success of PRP in the field of dermatology, with specific attention to the role of PRP in hair restoration. Where possible, meta-analyses were used to evaluate the efficacy of PRP. In androgenetic alopecia (AGA) patients, 3 monthly PRP injections (1 session administered every month for 3 months) exhibited greater efficacy over placebo as measured by change in total hair density (hair/cm2) over the treatment period (mean difference: 25.61, 95% CI: 4.45 to 46.77; P = .02). The studies included in the meta-analysis used a half-head design, which may have influenced the results because of the effects PRP can induce. Controlled studies suggest that 2 to 4 sessions of PRP combined with traditional therapies and procedures can help minimize acne scarring and facial burns, improve aesthetic results, and decrease recovery time. However, data for these indications are lacking and are less robust in design. In conclusion, to achieve an improvement in hair restoration in patients with mild AGA, 3 initial monthly PRP injections should be given. Only upon completion of rigorous, randomized, controlled studies can standardized and effective PRP protocols for treating dermatology conditions such as acne scarring, facial burns, and aging skin be determined.


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