THE EFFICACY OF A COMBINED IPL PROTOCOL AND A HYALURONIC ACID DRUG WITH MANNITOL FOR THE TREATMENT OF HYPERPIGMENTATION

Relevance: Today the world of therapeutic cosmetology is filled with a diverse range of methods, both laser and injection. They are aimed at the correction of various aesthetic problems. The most common complaint of a patient at a doctor-cosmetologist appointment is the presence of areas of hyperpigmentation in the facial area. In order to achieve a satisfactory result, the therapy of this pathology should be based on knowledge of the pathogenesis. In addition, it is necessary to take into account the possibility of side effects after laser treatment, which is the most frequent method chosen by doctors. Also, it is worth minimizing the risk of hyperpigmentation by improving the metabolic function of tissues. That is why the combined protocols open up the most promising horizons for the treatment of such difficult-to-correct pathology as hyperpigmentation. The aim of our study was to create an evidence base for the effectiveness of a combined treatment protocol using an IPL system in combination with a drug based on hyaluronic acid and mannitol. Materials and methods: The study involved female patients aged 18 to 45 years with a diagnosis of melasma Code L81.1; Other melanin hyperpigmentation L81.4. The study included patients who had not previously undergone laser and injection procedures in order to correct hyperpigmentation over the past 5-6 months. To evaluate the results, Antera 3D 3B visualizer in the “melanin” mode was used, as well as a laser Doppler flowmetry device Lazma-D. Results: A positive clinical result on the Antera 3D imager was observed in all study groups. It was statistically revealed that the variable Anadn did not differ between the control and experimental groups F (1.30) = 4.031, p = 0.050, ns), as well as before and after treatment (F (1.30) = 0.825, p = 0.368, ns ); the variable Afad did not differ between the control and experimental groups (F (1.30) = 2.483, p = 0.121, ns), as well as before and after treatment (F (1.30) = 3.142, p = 0.082, ns); the variable Mpm increased (p = 0.002) in the experimental group F (1.30) = 5.366, p = 0.024) after the exposure (F (1.30) = 4.718, p = 0.034); the Mpl variable did not differ between the control and experimental groups (F (1.30) = 0.61, p = 0.436, ns), as well as before and after treatment (F (1.30) = 0.028, p = 0.868, ns); The POM variable increased (p = 0.003) in the experimental group F (1.30) = 7.778, p = 0.007) after the treatment (F (1.30) = 8.541, p = 0.005). Conclusions: A significant improvement in the index of oxidative metabolism in tissues suggests that the combined protocol of hyperpigmentation therapy is the most effective and safe. In addition, such therapy allows physiological skin support during IPL therapy in combination with a preparation based on hyaluronic acid and mannitol.

Intraoral Venous Malformation-A Case report

The vascular anomalies consist of vascular tumours and vascular malformations. One among these are the venous malformations which constitute about 40% of all vascular malformations. Usually, the venous malformations present as localized lesions in the form of swellings/nodules with phleboliths, are diagnosed by ultrasonography, CT and MRI. Summary: This is a report of a rare longstanding case of wide spread venous malformations of oral cavity and facial area with phleboliths.

A Thermal Blended Facial Expression Analysis and Recognition System Using Deformed Thermal Facial Areas

There are many research works in visible as well as thermal facial expression analysis and recognition. Several facial expression databases have been designed in both modalities. However, little attention has been given for analyzing blended facial expressions in the thermal infrared spectrum. In this paper, we have introduced a Visual-Thermal Blended Facial Expression Database (VTBE) that contains visual and thermal face images with both basic and blended facial expressions. The database contains 12 posed blended facial expressions and spontaneous six basic facial expressions in both modalities. In this paper, we have proposed Deformed Thermal Facial Area (DTFA) in thermal expressive face image and make an analysis to differentiate between basic and blended expressions using DTFA. Here, the fusion of DTFA and Deformed Visual Facial Area (DVFA) has been proposed combining the features of both modalities and experiments and has been conducted on this new database. However, to show the effectiveness of our proposed approach, we have compared our method with state-of-the-art methods using USTC-NVIE database. Experiment results reveal that our approach is superior to state-of-the-art methods.

Handling of Scabies in Domestic Cat at Q-one Petklinik Surabaya

Background: Scabies is a skin disease caused by Sarcoptes scabiei. Scabies is transmitted through direct contact with animals affected by scabies or contact with the source of scabies mite in area of cat lives. Purpose: This study aims to determine the management of scabies at Q-One PetKlinik Surabaya. Method: Handling domestic cats affected by S.scabiei began with an interview with the owner and examinated with the physical condition of cats, and observed the body that was infected with S.scabiei. Scrabbing on scabs was conducted in the cat’s body which was located in the facial area, and followed by microscopic examination to observe the S.scabiei mite. Results: During April 2021, there were 13 domestic cats affected by scabies. Treatment for scabies was by administrated drugs containing 5% Permethrin. Cats were also given supportive therapy by grooming with antiectoparasite shampoo after two weeks from being given drugs. Conclusion: Handling cases of scabies in domestic cats at Q-One PetKlinik Surabaya is performed by cleaning the scab, applying an ointment containing 5% permethrin, and giving anti-histamine and anti-parasitic as well as providing supportive therapy in the form of grooming using shampoo containing anti-ectoparasites.

CASE REPORT: COMPLICATION AT BOTH RECEIVING AND DONOR SITES IN FACIAL AUTOLOGOUS FAT TRANSFER

Autologous fat grafting is a technique that has been used for a long time in the field of plastic surgery. Besides many advantages, the complications, which can range from mild such as hematoma, infection, calcification, necrosis... even death is a big problem. The article presents a case of using autologous fat taken from the abdomen to graft onto the facial area with complications of severe infection in both the receiving and donor sites, causing necrosis of fat and skin in both areas. The treatment takes a long time with different procedures, but the consequences for the patient are still very serious both in terms of aesthetics and function. The objective of this study was to evaluate the safety and efficacy of fat grafting to the facial region for the reconstruction and aesthetic enhancement of facial contour.

Polyacrylamide Injection vs. Polylactic Acid in HIV Related Lipodystrophy: A RCT Systematic Review

Lipodystrophy is an alteration of fat metabolism that commonly affects HIV-1 positive patients treated with antiretroviral therapy (ART). The facial area is most commonly affected by peripheral lipoatrophy, thus becoming a social stigma related to chronic HIV. Several treatments have been proposed, such as modification of diet, lifestyle and both surgical and nonsurgical procedures. The goal of our systematic review is to examine published clinical studies involving the use of polyacrylamide filler for the treatment of HIV FLA, and to provide evidence-based recommendations based on published efficacy and safety data. Our research was performed on published literature until April 2021. Polyacrylamide gel is a volumetric gel that has been proven stable, nontoxic, nonallergenic, nonembryotoxic and nonabsorbable. Poly-l-lactic acid (PLA) is a biocompatible, biodegradable, synthetic polymer derived from lactic acid. We believe it is essential to draft a pre- and post-injection and operative protocol to define an even setting for the clinical condition. It is desirable that such specifications are included in a large randomized controlled trial and the follow up is longer than the studies that we found, because as we have seen in the literature there are reported adverse events even 3 or 5 years after the injections.

Skin lesions caused by Orthopoxvirus, cowpox - case report from Poland

Background:Despite the elimination of smallpox, other orthopoxviruses, including cowpox virus, still infect humans. Wild rodents are its natural reservoir. Infections in humans are commonly reported from contact with sick domestic cats, rarely directly from rats. Cow pox in humans is a rare zoonotic disease, the diagnosis of which is problematic due to its rarity and thus the lack of clinical experience.Case report:Presented with a summary of the available clinical data on a 15-year-old boy who became infected with cowpox by a domestic cat.The patient developed cutaneous macular changes in the facial area. Within 3 weeks of the onset of symptoms, the lesions progressed through the papular, vesicular and pustular stages before forming a hard black eschars (2 cm in diameter) with erythema and edema and regional lifadenopathy. Differential diagnosis consisting of cat scratch disease, anthrax and brucellosis excluded microbiological examination. The lesions left scars after 8 weeks of continuous topical antiseptic treatment.Conclusions:The clinical course may be complicated, and the improvement takes 4 to 8 weeks. Infection which entered through the skin changes was the cause of antibiotic therapy. Cowpox should be suspected in patients with poorly healing skin lesions accompanied by a painful black eschars with erythema and local lymphadenopathy.

MANAGEMENT OF ODONTOGENIC INFECTION OF PRIMARY TEETH IN CHILD THAT EXTENDS TO THE SUBMANDIBULAR AND SUBMENTAL SPACES

Odontogenic infections are infections originating from the teeth or the supporting tissues of the teeth. This infection can spread to the alveolar processes, the deeper tissues of the face, oral cavity, head, and neck. Infections that spread to a child's facial area can progress rapidly, producing significant systemic symptoms, such as fever, malaise, dehydration, dysphagia, and respiratory distress. The purpose of this case report is to describe the management of odontogenic infection of primary teeth in child that extends to the submandibular and submental spaces. Case Report:A 5-year-old boy patient came to the Emergency Department of Hasan Sadikin Hospital Bandung with complaints of swelling in the right submental and submandibular for seven days. The patient complained of toothache, fever, and trismus. The diagnosis of this case was submandibular abscess extending to the submental area due to dental infection 85.. Patient care includes administering Ceftraxone inj 325 mg IV, Metronidazole inf 170 mg IV, Paracetamol inf 195 mg IV, tooth extraction 85, drainage incision through and through the right mandibular to submental, and installation of a Penrose drain. Conclusion:Odontogenic infections in children can originate from primary teeth and can extend to the maxillofacial space. Prompt and appropriate treatment of severe odontogenic infections in children needs to be done to prevent further complications

Case Report: GPi DBS for Non-parkinsonian Midline Tremor: A Normative Connectomic Comparison to a Failed Thalamic DBS

Introduction: The clinical efficacy of deep brain stimulation (DBS) for midline tremor has been heterogenous. Here, we present an atypical case with facial and palatal tremor treated with DBS. We aimed to show the difference between the fibers affected by stimulation of the two targets [globus pallidus interna (GPi) and ventral intermediate (Vim) thalamic nucleus] using a normative connectome analysis.Case Report: A 76-year-old woman with a 4-year history of severe facial and palatal tremor due to craniofacial dystonia. Following a failed bilateral Vim DBS, explantation of preexisting leads and implantation of bilateral GPi leads resulted in the resolution of tremor symptoms following a failed bilateral Vim DBS. We performed a normative connectome analysis using the volume of tissue activated (VTA) as a region of interest. The results revealed that the fiber tracts associated with VTA of GPi DBS had connections with the facial area of the motor cortex while the Vim DBS did not.Conclusion: This case study suggests the possibility that GPi DBS may be considered for midline tremor, and that the normative connectome analysis may possibly offer clues as to the structures underpinning a positive response. We may refine targets for some of the more difficult to control symptoms such as the midline tremor in this case.