Treatment of recalcitrant facial flat warts with ingenol mebutate gel with excellent results

2021 ◽  
Author(s):  
Lucía Quintana Castanedo ◽  
Eloy Tarín Vicente ◽  
Almudena Nuno‐Gonzalez ◽  
Pedro Herranz Pinto
Keyword(s):  
Ingenol Mebutate ◽  
Flat Warts

Ingenol Mebutate Gel

2020 ◽  
Author(s):  
Keyword(s):  
Ingenol Mebutate

Fluorouracil/imiquimod/ingenol mebutate

2021 ◽  
Vol 1864 (1) ◽  
pp. 166-166
Keyword(s):  
Ingenol Mebutate

scholarly journals Ingol and Ingenol-Type Diterpenes from Euphorbia trigona Miller with Keratinocyte Inhibitory Activity

Plants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1206
Author(s):  
Reham Hammadi ◽  
Norbert Kúsz ◽  
Csilla Zsuzsanna Dávid ◽  
Zoltán Behány ◽  
László Papp ◽  
...  
Keyword(s):  
Liquid Chromatography ◽  
Cytotoxic Activity ◽  
Inhibitory Activity ◽  
High Performance ◽  
Skin Condition ◽  
Positive Control ◽  
Active Species ◽  
The European Union ◽  
Ingenol Mebutate

Ingenol mebutate, isolated from Euphorbia peplus, is an ingenane-type diterpenoid, primarily used for the topical treatment of actinic keratosis, a premalignant skin condition. The aim of our work was to investigate other Euphorbia species to find structurally similar diterpenes that can be used as alternatives to ingenol mebutate. Pharmacological investigation of Euphorbia candelabrum, Euphorbia cotinifolia, Euphorbia ramipressa, and Euphorbia trigona revealed the potent keratinocyte (HPV-Ker cell line) inhibitory activity of these spurge species. From the methanolic extract of the aerial parts of Euphorbia trigona Miller, the most active species, five ingol (1–5) and four ingenane-type diterpenoids (6–9) were isolated by various chromatographic separation techniques, including open column chromatography, vacuum liquid chromatography, thin-layer chromatography, and high-performance liquid chromatography. The structures of the compounds were determined by NMR spectroscopic analysis and by comparison of the assignations with the literature data. The cytotoxic activity of the compounds against keratinocytes was tested in vitro by using ingenol mebutate as a positive control. Among the isolated compounds, two ingenane derivatives (6 and 7) exhibited remarkably stronger cytotoxic activity (IC50 values 0.39 μM and 0.32 μM, respectively) on keratinocytes than ingenol mebutate (IC50 value 0.84 μM). These compounds could serve as starting materials for further investigations to find alternatives to Picato® (with active substance ingenol mebutate), which was withdrawn from marketing authorization in the European Union.

A double-blind, randomized, placebo-controlled trial of oral isotretinoin in the treatment of recalcitrant facial flat warts

2014 ◽  
Vol 26 (1) ◽  
pp. 78-82 ◽  
Author(s):  
María Guadalupe Olguin-García ◽  
Fermín Jurado-Santa Cruz ◽  
María Luisa Peralta-Pedrero ◽  
Martha Alejandra Morales-Sánchez
Keyword(s):  
Controlled Trial ◽  
Double Blind ◽  
Oral Isotretinoin ◽  
Flat Warts

Ivacaftor, vismodegib, and ingenol mebutate

2012 ◽  
Vol 52 (3) ◽  
pp. 418-422 ◽  
Author(s):  
Daniel A. Hussar ◽  
Samuel P. Eckel
Keyword(s):  
Ingenol Mebutate

Ingenol mebutate

2015 ◽  
Vol 1566 (1) ◽  
pp. 133-133
Keyword(s):  
Ingenol Mebutate
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