scholarly journals Gut microbiome and amyotrophic lateral sclerosis ‐ a systematic review of current evidence

2021 ◽  
Author(s):  
Jiangwei Sun ◽  
Tingting Huang ◽  
Justine W. Debelius ◽  
Fang Fang
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Gut Microbiome ◽  
Current Evidence ◽  
Lateral Sclerosis

Statins and risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Fardin Nabizadeh ◽  
Mohammad Balabandian ◽  
Amir Mohammad Sharafi ◽  
Ali Ghaderi ◽  
Mohammad Reza Rostami ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Meta Analysis ◽  
Lateral Sclerosis

Assessment of dysarthria and dysphagia in patients with amyotrophic lateral sclerosis: Review of the current evidence

2021 ◽  
Author(s):  
Jimin Lee ◽  
Aarthi Madhavan ◽  
Elizabeth Krajewski ◽  
Sydney Lingenfelter
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Current Evidence ◽  
Lateral Sclerosis

Prognostic models for amyotrophic lateral sclerosis: a systematic review

2021 ◽  
Author(s):  
Lu Xu ◽  
Bingjie He ◽  
Yunjing Zhang ◽  
Lu Chen ◽  
Dongsheng Fan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Prognostic Models ◽  
Lateral Sclerosis

scholarly journals The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sarah L. Boddy ◽  
Ilaria Giovannelli ◽  
Matilde Sassani ◽  
Johnathan Cooper-Knock ◽  
Michael P. Snyder ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Phenotypic Variability ◽  
Personalised Medicine ◽  
Main Body ◽  
Body Of Knowledge ◽  
Environmental Component ◽  
Health And Disease ◽  
Lateral Sclerosis

Abstract Background Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present with no known underlying cause. Furthermore, even in families with a shared genetic abnormality there is significant phenotypic variability, suggesting that non-genetic elements may modify pathogenesis. Identification of such disease-modifiers is important as they might represent new therapeutic targets. A growing body of research has begun to shed light on the role played by the gut microbiome in health and disease with a number of studies linking abnormalities to ALS. Main body The microbiome refers to the genes belonging to the myriad different microorganisms that live within and upon us, collectively known as the microbiota. Most of these microbes are found in the intestines, where they play important roles in digestion and the generation of key metabolites including neurotransmitters. The gut microbiota is an important aspect of the environment in which our bodies operate and inter-individual differences may be key to explaining the different disease outcomes seen in ALS. Work has begun to investigate animal models of the disease, and the gut microbiomes of people living with ALS, revealing changes in the microbial communities of these groups. The current body of knowledge will be summarised in this review. Advances in microbiome sequencing methods will be highlighted, as their improved resolution now enables researchers to further explore differences at a functional level. Proposed mechanisms connecting the gut microbiome to neurodegeneration will also be considered, including direct effects via metabolites released into the host circulation and indirect effects on bioavailability of nutrients and even medications. Conclusion Profiling of the gut microbiome has the potential to add an environmental component to rapidly advancing studies of ALS genetics and move research a step further towards personalised medicine for this disease. Moreover, should compelling evidence of upstream neurotoxicity or neuroprotection initiated by gut microbiota emerge, modification of the microbiome will represent a potential new avenue for disease modifying therapies. For an intractable condition with few current therapeutic options, further research into the ALS microbiome is of crucial importance.

Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis

2017 ◽  
Vol 88 (7) ◽  
pp. 540-549 ◽  
Author(s):  
Zhang-Yu Zou ◽  
Zhi-Rui Zhou ◽  
Chun-Hui Che ◽  
Chang-Yun Liu ◽  
Rao-Li He ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Genetic Epidemiology ◽  
Meta Analysis ◽  
Lateral Sclerosis

scholarly journals The gut microbiome and neuroinflammation in amyotrophic lateral sclerosis? Emerging clinical evidence

2020 ◽  
Vol 135 ◽  
pp. 104300 ◽  
Author(s):  
Christina N. Fournier ◽  
Madelyn Houser ◽  
Malú G. Tansey ◽  
Jonathan D. Glass ◽  
Vicki Stover Hertzberg
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gut Microbiome ◽  
Clinical Evidence ◽  
Lateral Sclerosis

Efficacy and safety of edaravone in treatment of amyotrophic lateral sclerosis—a systematic review and meta-analysis

2018 ◽  
Vol 40 (2) ◽  
pp. 235-241 ◽  
Author(s):  
Linting Luo ◽  
Zhibin Song ◽  
Xiaoqiang Li ◽  
Huiwang ◽  
Yaqing Zeng ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Meta Analysis ◽  
Efficacy And Safety ◽  
Lateral Sclerosis

scholarly journals Depression and anxiety in individuals with amyotrophic lateral sclerosis: a systematic review

2016 ◽  
Vol 38 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Tatiana Lins Carvalho ◽  
Lilian Maria Sanguinett de Almeida ◽  
Camila Maria Araújo Lorega ◽  
Mirella Francyne Oliveira Barata ◽  
Maria Lúcia Brito Ferreira ◽  
...  
Keyword(s):  
Systematic Review ◽  
Amyotrophic Lateral Sclerosis ◽  
Depressive Disorders ◽  
Depression And Anxiety ◽  
Inclusion Criteria ◽  
Eligibility Criteria ◽  
Symptoms Of Depression ◽  
Two Stages ◽  
Different Levels ◽  
Lateral Sclerosis

Introduction Studies assessing symptoms of depression and anxiety in individuals with amyotrophic lateral sclerosis (ALS) have reported contradictory results. The objective of this systematic review is to identify the prevalence of these mood disorders in the literature. Methods We searched the PubMed, HighWire, MEDLINE, SciELO, LILACS and ScienceDirect databases. Literature was selected for review in two stages, according to eligibility criteria. The first stage involved searching databases and checking titles and abstracts. The second step consisted of reading complete articles and excluding those that did not meet the inclusion criteria. The inclusion criteria were articles written in Portuguese, English or Spanish, published in the last five years and involving people with ALS diagnosed according to the El Escorial criteria. Results The database searches returned a total of 1,135 titles and abstracts and then 1,117 of these were excluded. Eighteen articles were selected for review. The 12-item Amyotrophic Lateral Sclerosis Depression Inventory (ADI-12) was the only instrument designed specifically to assess depression in ALS, but it was only used in three studies. No instruments specifically designed for anxiety in ALS were used. A large number of studies found presence and slight increase of anxiety disorders. There was considerable large variation in the results related to depressive disorders, ranging from moderate depression to an absence of symptoms. Conclusions Patients with ALS may exhibit symptoms of depression and anxiety at different levels, but there is a need for studies using specific instruments with larger samples in order to ascertain the prevalence of symptoms in ALS and the factors associated with it.

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