Quantitative evaluation of brain iron accumulation in different stages of Parkinson's disease

2021 ◽  
Author(s):  
Kailyn R. Li ◽  
Josue Avecillas‐Chasin ◽  
Thanh D. Nguyen ◽  
Kelly M. Gillen ◽  
Alexey Dimov ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Quantitative Evaluation ◽  
Iron Accumulation ◽  
Brain Iron

An altered blood–brain barrier contributes to brain iron accumulation and neuroinflammation in the 6-OHDA rat model of Parkinson’s disease

Neuroscience ◽  
2017 ◽  
Vol 362 ◽  
pp. 141-151 ◽  
Author(s):  
Sonia Olmedo-Díaz ◽  
Héctor Estévez-Silva ◽  
Greger Orädd ◽  
Sara af Bjerkén ◽  
Daniel Marcellino ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Brain Barrier ◽  
Rat Model ◽  
Iron Accumulation ◽  
Brain Barrier ◽  
Brain Iron ◽  
Blood Brain ◽  
Altered Blood

Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

Neuroscience ◽  
2015 ◽  
Vol 284 ◽  
pp. 234-246 ◽  
Author(s):  
L.-H. You ◽  
F. Li ◽  
L. Wang ◽  
S.-E. Zhao ◽  
S.-M. Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Iron Accumulation ◽  
Brain Iron

scholarly journals Regional brain iron and gene expression provide insights into neurodegeneration in Parkinson’s disease

Brain ◽  
2021 ◽  
Author(s):  
George E C Thomas ◽  
Angeliki Zarkali ◽  
Mina Ryten ◽  
Karin Shmueli ◽  
Ana Luisa Gil Martinez ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Expression Profiles ◽  
Nervous System Development ◽  
Synaptic Function ◽  
Iron Accumulation ◽  
Iron Deposition ◽  
Brain Atlas ◽  
Biological Processes ◽  
Brain Iron

Abstract The mechanisms which are responsible for the selective vulnerability of specific neuronal populations in Parkinson’s disease are poorly understood. Oxidative stress secondary to brain iron accumulation is one postulated mechanism. We measured iron deposition in 180 cortical regions in 96 patients with Parkinson’s disease and 35 controls using quantitative susceptibility mapping. We estimated the expression of 15 745 genes in the same regions using transcriptomic data from the Allen Human Brain Atlas. Using partial least squares regression, we then identified the profile of gene transcription in the healthy brain that underlies increased cortical iron in patients with Parkinson’s disease relative to controls. With gene ontological tools, we investigated the biological processes and cell types associated with this transcriptomic profile. We identified the sets of genes whose spatial expression profiles in control brains correlated significantly with the spatial pattern of cortical iron deposition in Parkinson’s disease. Gene ontological analyses revealed that these genes were enriched for biological processes relating to heavy metal detoxification, synaptic function and nervous system development and were predominantly expressed in astrocytes and glutamatergic neurons. We also show that genes found to be differentially expressed in Parkinson’s disease play a role in explaining the pattern of cortical expression we identified. Our findings provide mechanistic insights into regional selective vulnerabilities in Parkinson’s disease, particularly into processes involving iron accumulation.

scholarly journals Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Antonio Martin-Bastida ◽  
Roberta J. Ward ◽  
Rexford Newbould ◽  
Paola Piccini ◽  
David Sharp ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Clinical Trial ◽  
Parkinson's Disease ◽  
Iron Chelation ◽  
Controlled Clinical Trial ◽  
Phase 2 ◽  
Brain Iron ◽  
Double Blinded

scholarly journals Analyzing the co-localization of substantia nigra hyper-echogenicities and iron accumulation in Parkinson's disease: A multi-modal atlas study with transcranial ultrasound and MRI

2020 ◽  
Vol 26 ◽  
pp. 102185 ◽  
Author(s):  
Seyed-Ahmad Ahmadi ◽  
Kai Bötzel ◽  
Johannes Levin ◽  
Juliana Maiostre ◽  
Tassilo Klein ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Iron Accumulation ◽  
Transcranial Ultrasound

Iron accumulation in Parkinson’s disease

2012 ◽  
Vol 119 (12) ◽  
pp. 1511-1514 ◽  
Author(s):  
Hideki Mochizuki ◽  
Toru Yasuda
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Iron Accumulation
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