Oral health is a mediator for disease severity in patients with Behçet’s disease: A multiple mediation analysis study

The purpose of this study was to clarify the role of pattern recognition receptors in Behçet’s disease (BD). The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- (IL-) 18, IL-23, and IL-17A, were compared in plasma. The analysis was performed in active (n=13) and inactive (n=13) stages of BD patients. Rheumatoid arthritis patients (n=19), as a disease control, and healthy control (HC) (n=19) were enrolled. The frequencies of CD11b+ and CD32+ cells were significantly increased in active BD patients compared to HC. Disease severity score was correlated to CD11c+, CD206+, and CD209+ in whole leukocytes and CD11b+, CD11c+, CD206+, CD209+, and Dectin-1+ in granulocytes. The plasma levels of IL-17A were significantly different between HC and active BD. IL-18 showed significant difference between active and inactive BD patients. From this study, we concluded the expressions of several pattern recognition receptors were correlated to the joint symptoms of BD.

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Classifying patients with Behçet’s disease for disease severity, using a discriminating analysis method

Clinical and Experimental Dermatology ◽

10.1111/j.1365-2230.2008.02811.x ◽

2009 ◽

Vol 34 (2) ◽

pp. 151-155 ◽

Cited By ~ 2

Author(s):

M. Polat ◽

G. Vahaboglu ◽

U. Önde ◽

M. Eksioglu

Keyword(s):

Disease Severity ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Analysis Method ◽

Behcet's Disease

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Decreasing incidence and severity of Behçet’s disease: a changing trend in epidemiological spectrum possibly associated with oral health

TURKISH JOURNAL OF MEDICAL SCIENCES ◽

10.3906/sag-2003-147 ◽

2020 ◽

Vol 50 (7) ◽

pp. 1587-1590

Author(s):

Gonca MUMCU ◽

Fatma ALİBAZ ÖNER ◽

Tülin ERGUN ◽

Haner DİRESKENELİ

Keyword(s):

Oral Health ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Epidemiological Studies ◽

Inflammatory Disorder ◽

Behcet's Disease ◽

Disease Spectrum ◽

Wide Range ◽

Ancient Silk Road

Behçet’s disease (BD) is a systemic and inflammatory disorder that is mainly present along the ancient Silk Road, from the Mediterranean Sea to East Asia. A wide range of prevalence figures (0.1–420/100,000) have been reported for BD, also among Turkish populations of similar genetic background living in different countries. Recently, a decline in the incidence of BD and a change of the disease spectrum to less-severe manifestations have been reported from Japan and Korea, two genetically homogenous, affluent populations with limited immigration. It was hypothesized that a decline in infectious diseases, especially dental/periodontal infections, associated with the improvement in oral health, could be a part of these changes in the disease expression. Further epidemiological studies in other populations might demonstrate whether there is a worldwide similar trend and may provide a better understanding of the triggering factors for the onset and course of BD.

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