scholarly journals Serum cardiac troponin I concentrations in dogs with generalised seizures

2017 ◽  
Vol 59 (3) ◽  
pp. 167-173 ◽  
Author(s):  
E. Dutton ◽  
N. Carmichael ◽  
U. Michal ◽  
P. J. Cripps ◽  
A. Boswood
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin

Evaluation of Myocardial Injury Following Repeated Internal Atrial Shocks by Monitoring Serum Cardiac Troponin I Levels

CHEST Journal ◽  
2000 ◽  
Vol 118 (2) ◽  
pp. 342-347 ◽  
Author(s):  
Giuseppe Boriani ◽  
Mauro Biffi ◽  
Vittorio Cervi ◽  
Gabriele Bronzetti ◽  
Giorgia Magagnoli ◽  
...  
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin

Assessment of left ventricular function using serum cardiac troponin I measurements following myocardial infarction

1998 ◽  
Vol 272 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Fred S. Apple ◽  
Scott W. Sharkey ◽  
Alireza Falahati ◽  
Maryann Murakami ◽  
Naheed Mitha ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Left Ventricular ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin

scholarly journals Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m2) cyclophosphamide

2001 ◽  
Vol 28 (3) ◽  
pp. 277-282 ◽  
Author(s):  
P Morandi ◽  
PA Ruffini ◽  
GM Benvenuto ◽  
L La Vecchia ◽  
G Mezzena ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
High Dose ◽  
Breast Cancer Patients ◽  
Serum Cardiac Troponin

Serum cardiac troponin I in canine syncope and seizures

2017 ◽  
Vol 19 (1) ◽  
pp. 1-13 ◽  
Author(s):  
E. Dutton ◽  
J. Dukes-McEwan ◽  
P.J. Cripps
Keyword(s):  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Serum Cardiac Troponin

scholarly journals Degradation of Cardiac Troponin I in Serum Complicates Comparisons of Cardiac Troponin I Assays

1999 ◽  
Vol 45 (7) ◽  
pp. 1018-1025 ◽  
Author(s):  
Qinwei Shi ◽  
Mingfu Ling ◽  
Xiaochen Zhang ◽  
Minyuan Zhang ◽  
Lilly Kadijevic ◽  
...  
Keyword(s):  
Western Blot ◽  
Human Serum ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Stable Region ◽  
Terminal Portion ◽  
Key Factor ◽  
The Stability ◽  
Serum Cardiac Troponin

Abstract Background: Up to a 20-fold variation in serum cardiac troponin I (cTnI) concentration may be observed for a given patient sample with different analytical methods. Because more limited variation is seen for control materials and for purified cTnI, we explored the possibility that cTnI was present in altered forms in serum. Methods: We used four recombinantly engineered cTnI fragments to study the regions of cTnI recognized by the Stratus®, Opus®, and ACCESS® immunoassays. The stability of these regions in serum was analyzed with Western blot. Results: The measurement of several control materials and different forms of purified cTnI using selected commercial assays demonstrated five- to ninefold variation. Both the Stratus and Opus assays recognized the N-terminal portion (NTP) of cTnI, whereas the ACCESS assay recognized the C-terminal portion (CTP) of cTnI. Incubation of recombinant cTnI in normal human serum produced a marked decrease in cTnI concentration as determined with the ACCESS, but not the Stratus, immunoassay. Western blot analysis of the same samples using cTnI NTP- and CTP-specific antibodies demonstrated preferential degradation of the CTP of cTnI. Conclusions: The availability of serum cTnI epitopes is markedly affected by the extent of ligand degradation. The N-terminal half of the cTnI molecule was found to be the most stable region in human serum. Differential degradation of cTnI is a key factor in assay-to-assay variation.

scholarly journals Improved detection of minor ischemic myocardial injury with measurement of serum cardiac troponin I

1997 ◽  
Vol 43 (11) ◽  
pp. 2047-2051 ◽  
Author(s):  
Fred S Apple ◽  
Alireza Falahati ◽  
Pamela R Paulsen ◽  
Elizabeth A Miller ◽  
Scott W Sharkey
Keyword(s):  
Cardiac Troponin ◽  
Myocardial Injury ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Clinical Sensitivity ◽  
Reference Limit ◽  
Normal Limits ◽  
Serial Serum ◽  
Upper Reference Limit ◽  
Serum Cardiac Troponin

Abstract This study compared the diagnostic accuracy of the measurement of serum cardiac troponin I (cTnI) with creatine kinase (CK) MB mass in patients with minor myocardial injury whose measured total CK activity did not exceed twice the upper reference limit (300 U/L for men; 200 U/L for women). Forty-eight consecutive patients presenting with chest pain and with in-hospital documentation of myocardial injury were enrolled. Electrocardiogram, echocardiogram, and serial serum CK-MB mass, cTnI, and total CK were measured over 36 h after admission. Peak total CK activity was within normal limits in 28 patients (58%). The mean (±SD) peak CK-MB mass and cTnI concentrations were: 16.4 (11.8) μg/L and 132 (13.0) μg/L; respectively. The peak biochemical marker index (defined as CK-MB or cTnI divided by its respective upper reference limit) was significantly (P <0.05) higher for cTnI than for CK-MB from 7 to 36 h. The clinical sensitivity for detection of myocardial injury for cTnI was 100% [95% confidence interval (CI): 87.2% to 100%], compared with 81.8% (CI: 67.3% to 91.8%) for CK-MB. Thus, cTnI was more sensitive than CK-MB mass for detection of myocardial injury in patients with small increases of total CK.

scholarly journals Raised serum cardiac troponin I concentrations predict hospital mortality in intensive care unit patients †

2012 ◽  
Vol 109 (2) ◽  
pp. 219-224 ◽  
Author(s):  
T. Reynolds ◽  
M. Cecconi ◽  
P. Collinson ◽  
A. Rhodes ◽  
R.M. Grounds ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Hospital Mortality ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Cardiac Troponin I ◽  
Predict Hospital Mortality ◽  
Serum Cardiac Troponin
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