scholarly journals Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction

2015 ◽  
Vol 22 (4) ◽  
pp. 237-248 ◽  
Author(s):  
Shaquria P. Adderley ◽  
Xun E. Zhang ◽  
Jerome W. Breslin
Keyword(s):  
Map Kinase ◽  
Histamine Receptor ◽  
P38 Map Kinase ◽  
Endothelial Barrier ◽  
Light Chains ◽  
Myosin Light Chains ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction

p38 MAP kinase mediates burn serum-induced endothelial barrier dysfunction: involvement of F-actin rearrangement and l-caldesmon phosphorylation

Shock ◽  
2010 ◽  
pp. 1 ◽  
Author(s):  
Zhi-gang Chu ◽  
Jia-ping Zhang ◽  
Hua-pei Song ◽  
Jiong-yu Hu ◽  
Qiong Zhang ◽  
...  
Keyword(s):  
Map Kinase ◽  
P38 Map Kinase ◽  
Endothelial Barrier ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction ◽  
Actin Rearrangement

P38 MAP KINASE MEDIATES BURN SERUM-INDUCED ENDOTHELIAL BARRIER DYSFUNCTION

Shock ◽  
2010 ◽  
Vol 34 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Zhi-gang Chu ◽  
Jia-ping Zhang ◽  
Hua-pei Song ◽  
Jiong-yu Hu ◽  
Qiong Zhang ◽  
...  
Keyword(s):  
Map Kinase ◽  
P38 Map Kinase ◽  
Endothelial Barrier ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction

The hawthorn special extract WS® 1442 protects against endothelial barrier dysfunction – elucidation of the underlying molecular mechanisms

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
R Fürst ◽  
M Bubik ◽  
P Bihari ◽  
G Jürgenliemk ◽  
H Ammer ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Endothelial Barrier ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction

Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death

2021 ◽  
Vol 556 ◽  
pp. 199-206
Author(s):  
Toria Tomasek ◽  
Lorraine B. Ware ◽  
Julie A. Bastarache ◽  
Jamie E. Meegan
Keyword(s):  
Cell Death ◽  
Human Lung ◽  
Endothelial Barrier ◽  
Free Hemoglobin ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction ◽  
Microvascular Endothelial

scholarly journals Atrial Natriuretic Peptide Protects against Histamine-Induced Endothelial Barrier Dysfunction in Vivo

2008 ◽  
Vol 74 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Robert Fürst ◽  
Martin F. Bubik ◽  
Peter Bihari ◽  
Bettina A. Mayer ◽  
Alexander G. Khandoga ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Endothelial Barrier ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction ◽  
Atrial Natriuretic

scholarly journals Microtubule destabilization caused by particulate matter contributes to lung endothelial barrier dysfunction and inflammation

2019 ◽  
Vol 53 ◽  
pp. 246-255 ◽  
Author(s):  
Pratap Karki ◽  
Angelo Meliton ◽  
Albert Sitikov ◽  
Yufeng Tian ◽  
Tomomi Ohmura ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Endothelial Barrier ◽  
Barrier Dysfunction ◽  
Endothelial Barrier Dysfunction

scholarly journals Pigment Epithelium-Derived Factor Induces Endothelial Barrier Dysfunction via p38/MAPK Phosphorylation

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ting He ◽  
Liping Zhao ◽  
Dongxia Zhang ◽  
Qiong Zhang ◽  
Jiezhi Jia ◽  
...  
Keyword(s):  
P38 Mapk ◽  
Umbilical Vein ◽  
Pigment Epithelium ◽  
Endothelial Barrier ◽  
Dependent Manner ◽  
Barrier Dysfunction ◽  
Edema Formation ◽  
Endothelial Barrier Dysfunction ◽  
Pigment Epithelium Derived Factor

Endothelial barrier dysfunction, which is a serious problem that occurs in various inflammatory conditions, permits extravasation of serum components into the surrounding tissues, leading to edema formation and organ failure. Pigment epithelium-derived factor (PEDF), which is a major endogenous antagonist, has been implicated in diverse biological process, but its role in endothelial barrier dysfunction has not been defined. To assess the role of PEDF in the vasculature, we evaluated the effects of exogenous PEDF using human umbilical vein endothelial cells (HUVECs)in vitro. Our results demonstrated that exogenous PEDF activated p38/MAPK signalling pathway in a dose- and time-dependent manner and induced vascular hyperpermeability as measured by the markedly increased FITC-dextran leakage and the decreased transendothelial electrical resistance (TER) across the monolayer cells, which was accompanied by microtubules (MTs) disassembly and F-actin rearrangement. However, the aforementioned alterations can be arrested by the application of low concentration of p38/MAPK inhibitor SB203580. These results reveal a novel role for PEDF as a potential vasoactive substance in inducing hyperpermeability. Furthermore, our results suggest that PEDF and p38/MAPK may serve as therapeutic targets for maintaining vascular integrity.

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