scholarly journals Invited review: Frontotemporal dementia caused by microtubule‐associated protein tau gene ( MAPT ) mutations: a chameleon for neuropathology and neuroimaging

2015 ◽  
Vol 41 (1) ◽  
pp. 24-46 ◽  
Author(s):  
Bernardino Ghetti ◽  
Adrian L. Oblak ◽  
Bradley F. Boeve ◽  
Keith A. Johnson ◽  
Bradford C. Dickerson ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau

scholarly journals From genetics to pathology: tau and a–synuclein assemblies in neurodegenerative diseases

2001 ◽  
Vol 356 (1406) ◽  
pp. 213-227 ◽  
Author(s):  
Michel Goedert ◽  
Maria Grazia Spillantini ◽  
Louise C. Serpell ◽  
John Berriman ◽  
Michael J. Smith ◽  
...  
Keyword(s):  
Human Brain ◽  
Neurodegenerative Diseases ◽  
Frontotemporal Dementia ◽  
Glial Cells ◽  
Tau Protein ◽  
Nerve Cells ◽  
Degenerative Diseases ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau ◽  
Filamentous Inclusions

The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule–associated protein tau or the protein α–synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutations in the α–synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and α–synuclein can cause neurodegeneration.

scholarly journals DrosophilaModels of Tauopathies: What Have We Learned?

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Marc Gistelinck ◽  
Jean-Charles Lambert ◽  
Patrick Callaerts ◽  
Bart Dermaut ◽  
Pierre Dourlen
Keyword(s):  
Frontotemporal Dementia ◽  
High Throughput ◽  
Neurodegenerative Disorders ◽  
Genetic Model ◽  
Model Organism ◽  
Molecular Pathways ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau ◽  
The Past ◽  
Genome Wide

Aggregates of the microtubule-associated protein Tau are neuropathological hallmark lesions in Alzheimer's disease (AD) and related primary tauopathies. In addition, Tau is genetically implicated in a number of human neurodegenerative disorders including frontotemporal dementia (FTD) and Parkinson's disease (PD). The exact mechanism by which Tau exerts its neurotoxicity is incompletely understood. Here, we give an overview of how studies using the genetic model organismDrosophilaover the past decade have contributed to the molecular understanding of Tau neurotoxicity. We compare the different available readouts for Tau neurotoxicity in flies and review the molecular pathways in which Tau has been implicated. Finally, we emphasize that the integration of genome-wide approaches in human or mice with high-throughput genetic validation inDrosophilais a fruitful approach.

scholarly journals Microtubule-associated protein tau genetic variations are uncommon cause of frontotemporal dementia in south India

2014 ◽  
Vol 35 (2) ◽  
pp. 443.e23-443.e24 ◽  
Author(s):  
P.M. Aswathy ◽  
P.S. Jairani ◽  
Joe Verghese ◽  
Srinivas Gopala ◽  
P.S. Mathuranath
Keyword(s):  
Frontotemporal Dementia ◽  
South India ◽  
Genetic Variations ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau

scholarly journals High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

1999 ◽  
Vol 64 (2) ◽  
pp. 414-421 ◽  
Author(s):  
Patrizia Rizzu ◽  
John C. Van Swieten ◽  
Marijke Joosse ◽  
Masato Hasegawa ◽  
Martijn Stevens ◽  
...  
Keyword(s):  
The Netherlands ◽  
Frontotemporal Dementia ◽  
Population Study ◽  
Protein Tau ◽  
Microtubule Associated Protein Tau ◽  
High Prevalence
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