Proteomic Analysis of the Cerebrospinal Fluid in Patients With Essential Tremor Before and After Deep Brain Stimulation Surgery: A Pilot Study

2019 ◽  
Vol 23 (4) ◽  
pp. 502-508 ◽  
Author(s):  
Peter Zsigmond ◽  
Stefan A. Ljunggren ◽  
Bijar Ghafouri
Keyword(s):  
Cerebrospinal Fluid ◽  
Deep Brain Stimulation ◽  
Pilot Study ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Proteomic Analysis ◽  
Before And After ◽  
Deep Brain Stimulation Surgery ◽  
Deep Brain

Gait worsening and the microlesion effect following deep brain stimulation for essential tremor

2019 ◽  
Vol 90 (8) ◽  
pp. 913-919 ◽  
Author(s):  
Ryan Roemmich ◽  
Jaimie A Roper ◽  
Robert S Eisinger ◽  
Jackson N Cagle ◽  
Lauren Maine ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Repeated Measures ◽  
Walking Speed ◽  
Stimulation Parameters ◽  
Gait Parameters ◽  
Before And After ◽  
Walking Speeds ◽  
Deep Brain

ObjectiveTo investigate the effects of unilateral thalamic deep brain stimulation (DBS) on walking in persons with medication-refractory essential tremor (ET).MethodsWe performed laboratory-based gait analyses on 24 persons with medication-refractory ET before and after unilateral thalamic DBS implantation. Normal and tandem walking parameters were analysed across sessions (PRE-DBS/DBS OFF/DBS ON) by repeated measures analyses of variance. Pearson’s correlations assessed whether changes in walking after DBS were global (ie, related across gait parameters). Baseline characteristics, lead locations and stimulation parameters were analysed as possible contributors to gait effects.ResultsDBS minimally affected gait at the cohort level. However, 25% of participants experienced clinically meaningful gait worsening. Walking speed decreased by >30% in two participants and by >10% in four others. Decreased walking speed correlated with increased gait variability, indicating global gait worsening in affected participants. The worsening persisted even after the stimulation was turned off. Participants with worse baseline tandem walking performance may be more likely to experience post-DBS gait worsening; the percentage of tandem missteps at baseline was nearly three times higher and tandem walking speeds were approximately 30% slower in participants who experienced gait worsening. However, these differences in tandem walking in persons with gait worsening as compared with those without worsening were not statistically significant. Lead locations and stimulation parameters were similar in participants with and without gait worsening.ConclusionGlobal gait worsening occurred in 25% of participants with unilateral DBS for medication-refractory ET. The effect was present on and off stimulation, likely indicating a microlesion effect.

Comprehensive Evaluation of Voice-Specific Outcomes in Patients With Essential Tremor Before and After Deep Brain Stimulation

2020 ◽  
Author(s):  
Kathryn W. Ruckart ◽  
Mary E. Moya-Mendez ◽  
Moeko Nagatsuka ◽  
Julia L. Barry ◽  
Mustafa S. Siddiqui ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Comprehensive Evaluation ◽  
Before And After ◽  
Deep Brain

Mood and motor effects of thalamic deep brain stimulation surgery for essential tremor

2010 ◽  
Vol 17 (8) ◽  
pp. 1040-1046 ◽  
Author(s):  
J. Graff-Radford ◽  
K. D. Foote ◽  
A. E. Mikos ◽  
D. Bowers ◽  
H. H. Fernandez ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Motor Effects ◽  
Deep Brain Stimulation Surgery ◽  
Deep Brain

scholarly journals Proteomic Analysis of the Cerebrospinal Fluid of Parkinson's Disease Patients Pre- and Post-Deep Brain Stimulation

2013 ◽  
Vol 31 (4-5) ◽  
pp. 625-637 ◽  
Author(s):  
Er-Song Wang ◽  
Hui-Bin Yao ◽  
Ying-Hui Chen ◽  
Gan Wang ◽  
Wen-Wei Gao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cerebrospinal Fluid ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Proteomic Analysis ◽  
Deep Brain

PSYCHOGENIC TREMOR OCCURRING AFTER DEEP BRAIN STIMULATION SURGERY FOR ESSENTIAL TREMOR

Neurology ◽  
2008 ◽  
Vol 70 (Issue 16, Part 2) ◽  
pp. 1498-1499 ◽  
Author(s):  
A. McKeon ◽  
J. E. Ahlskog ◽  
J. Y. Matsumoto
Keyword(s):  
Deep Brain Stimulation ◽  
Essential Tremor ◽  
Brain Stimulation ◽  
Deep Brain Stimulation Surgery ◽  
Deep Brain
Sign in / Sign up

Export Citation Format

Share Document