Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant irritable bowel syndrome and functional constipation

2016 ◽  
Vol 28 (4) ◽  
pp. 581-591 ◽  
Author(s):  
L. Neri ◽  
P. Iovino ◽  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Treatment Satisfaction ◽  
Functional Constipation ◽  
Irritable Bowel ◽  
Treatment Responsiveness

Effect of Diarrhea Adverse Events on Health-Related Quality of Life and Treatment Satisfaction in Patients With Irritable Bowel Syndrome With Constipation

2014 ◽  
Vol 109 ◽  
pp. S645
Author(s):  
William Spalding ◽  
Jessica Buono ◽  
Huan Huang ◽  
Michael Munsell ◽  
Douglas Taylor ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Adverse Events ◽  
Treatment Satisfaction ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Irritable Bowel

Sa1072 Symptom Control, Quality of Life, and Treatment Satisfaction in Patients Treated With Lubiprostone vs. Other Treatments for Irritable Bowel Syndrome-Constipation (IBS-C)

2014 ◽  
Vol 146 (5) ◽  
pp. S-192
Author(s):  
Caitlyn T. Solem ◽  
Haridarshan Patel ◽  
Sonam Mehta ◽  
Reema Mody ◽  
Monica Katyal ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Treatment Satisfaction ◽  
Symptom Control ◽  
Control Quality ◽  
Irritable Bowel

scholarly journals Functional Constipation and Constipation-Predominant Irritable Bowel Syndrome in the General Population: Data from the GECCO Study

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Paul Enck ◽  
Johannes Leinert ◽  
Menno Smid ◽  
Thorsten Köhler ◽  
Juliane Schwille-Kiuntke
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Physical Health ◽  
Clinical Characteristics ◽  
Functional Constipation ◽  
German Population ◽  
Rome Criteria ◽  
Health Domain ◽  
Irritable Bowel

Background. The prevalence of constipation in the (German) population has been shown to be 14.9% in a telephone survey, but more detailed data are required to characterize the sociographics and clinical characteristics of persons with different types of functional constipation, either constipation-predominant irritable bowel syndrome (IBS-C) or functional constipation with or without meeting Rome criteria.Methods. Of 2239 constipated individuals identified during the telephone interview, 1037 (46.3%) were willing to provide a postal address for a questionnaire, of which 589 (56.8%) returned the questionnaire, inquiring about sociographic data, clinical symptoms, and health care behavior related to constipation, as well as health-related quality-of-life (SF12). Subgroups of functionally constipated individuals were compared.Results. More than 50% of the respondents reported a somatic comorbid condition and/or regular medication intake that may contribute to constipation. We split the remaining individuals (N=214) into three groups, matching Rome-criteria for IBS (IBS-C,n=64) and for functional constipation (FC-R,n=36) and FC not matching Rome criteria (n=114). Nearly all sociographic and clinical characteristics were equal among them, and all individuals with constipation had similar and lowered QOL on the SF-12 physical health domain, but in IBS-C the scores were also significantly lower in comparison to FC-R and FC, in both the physical health and the mental health domain.Conclusion. Only a fraction of individuals with chronic constipation match Rome criteria for IBS-C or FC, but subgroups do not differ with respect to most other measures except quality-of-life profiles.

scholarly journals Prevalence of functional constipation and constipation-predominant irritable bowel syndrome in Indian patients with constipation

2017 ◽  
Vol 6 (2) ◽  
pp. 275 ◽  
Author(s):  
Ramesh Rooprai ◽  
Naresh Bhat ◽  
Rajesh Sainani ◽  
Mayur M. Mayabhate
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Dietary Habits ◽  
Functional Constipation ◽  
Life Questionnaire ◽  
Comorbid Conditions ◽  
Patient Assessment ◽  
Stool Form ◽  
Irritable Bowel

Background: Evaluate prevalence of functional constipation (FC) and irritable bowel syndrome-constipation (IBS-C) in Indian constipated patients and assess their demographic/socio-economic/clinical characteristics.Methods: Patients (≥18 years) who visited their general physician with symptoms of constipation (Rome III criteria for FC or IBS-C as per physician assessment) and willing to participate were enrolled in this prospective, clinical-epidemiological study. Demographic, socioeconomic status, lifestyle and dietary habits, comorbid conditions, treatment history, concomitant medications, stool form (Bristol stool form scale), severity of constipation (constipation scoring system [CSS]), constipation-related symptoms (patient assessment of constipation symptoms [PAC-SYM]) and quality of life (patient assessment of constipation-quality of life questionnaire [PAC-QoL]) were recorded.Results: Out of 925 constipated patients, 75.6% were diagnosed with FC against 24.4% with IBS-C (P < 0.0001). Patients of both subtypes had high average scores of PAC-SYM (FC: 27.1 ± 6; IBS-C: 30.1 ± 4.9) and CSS (FC: 8.4 ± 3.1; IBS-C: 11.2 ± 3), leading to high PAC-QoL score (FC: 38.1 ± 16.8; IBS-C: 42.2 ± 13.6). Hypertension (16%) and diabetes (10%) in patients with FC while acid peptic disorders (21.7%) amongst IBS-C patients were the most common comorbid conditions observed. Laxatives were the most common medication used; osmotic (32.6% versus 40.7%) and bulk laxatives (22.8% versus 37.4%) were the commonest laxatives. However, about 1/5th patients of FC were using home remedies.Conclusions: There was a higher prevalence of FC over IBS-C in Indian constipated patients; both subtypes had high frequency and severity of constipation-related symptoms and poor QoL.

Health releated quality of life in irritable bowel syndrome: A community based study+

2001 ◽  
Vol 120 (5) ◽  
pp. A634-A634 ◽  
Author(s):  
K OLDEN ◽  
W CHEY ◽  
J BOYLE ◽  
E CARTER ◽  
L CHANG
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Community Based ◽  
Irritable Bowel

Cross-cultural comparison of quality of life in irritable bowel syndrome (IBS)

2001 ◽  
Vol 120 (5) ◽  
pp. A759-A759
Author(s):  
P ENCK ◽  
S KLOSTERHALFEN ◽  
M BEHRENS
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Cross Cultural ◽  
Cultural Comparison ◽  
Cross Cultural Comparison ◽  
Irritable Bowel

P0075 THE IRRITABLE BOWEL SYNDROME AND ITS EFFECT ON THE QUALITY OF LIFE

2009 ◽  
Vol 20 ◽  
pp. S32
Author(s):  
Sevinç Kutlutürkan ◽  
Ülkü Görgülü ◽  
Hatice Fesci
Keyword(s):  
Quality Of Life ◽  
Irritable Bowel Syndrome ◽  
Irritable Bowel

scholarly journals Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

2021 ◽  
Vol 14 ◽  
pp. 175628482199358
Author(s):  
Nikita Hanning ◽  
Adam L. Edwinson ◽  
Hannah Ceuleers ◽  
Stephanie A. Peters ◽  
Joris G. De Man ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Barrier Function ◽  
Significant Proportion ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Irritable Bowel

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

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