Ameliorating effects of sacral neuromodulation on gastric and small intestinal dysmotility mediated via a sacral afferent‐vagal efferent pathway

2020 ◽  
Vol 32 (7) ◽  
Author(s):  
Ximeng Wang ◽  
Shengai Zhang ◽  
Pankaj J. Pasricha ◽  
Jiande D. Z. Chen
Keyword(s):  
Sacral Neuromodulation ◽  
Efferent Pathway ◽  
Intestinal Dysmotility ◽  
Afferent Vagal ◽  
Small Intestinal

Nutritional considerations in severe primary chronic small intestinal dysmotility

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Thomas Edward Conley ◽  
Simon Lal
Keyword(s):  
Intestinal Dysmotility ◽  
Small Intestinal

Small intestinal dysmotility in cirrhotic patients: correlation with severity of liver disease and cirrhosis-associated complications

2020 ◽  
Author(s):  
Felix Gundling ◽  
Margo Luxi ◽  
Holger Seidel ◽  
Wolfgang Schepp ◽  
Thomas Schmidt
Keyword(s):  
Visual Analysis ◽  
Phase Iii ◽  
Healthy Controls ◽  
Motor Patterns ◽  
Postprandial Motility ◽  
Intestinal Dysmotility ◽  
Computer Aided Analysis ◽  
Cirrhotic Patients ◽  
Small Intestinal ◽  
Small Bowel Manometry

Abstract Introduction Altered small intestinal motility has been observed in various manometry studies in patients with cirrhosis. Since small bowel manometry is available only in a few centers, interpretation of dysmotility in cirrhosis is controversial. Patients and Methods In this study, both fasting and postprandial manometric tracings of 24-hour antroduodenojejunal manometries were analyzed using both visual analysis and computer-aided analysis. Results In 34 patients (83 %), the mean migrating motor complex (MMC) cycle length was different compared with healthy controls. Phase II was prolonged in 27 patients (66 %), while phase I showed a reduced duration in 23 (56 %) and in phase III in 13 individuals (32 %). We also observed special motor patterns, e. g., migrating clustered contractions (MCCs) or retrograde clustered contractions (RCCs), which were present during fasting (69 %) and postprandial (92 %) motility, while none of the healthy controls showed any special motor patterns. Special motor patterns showed a significant correlation with the severity of cirrhosis (Child-Score; p > 0.05) and the existence of ascites (p < 0.05). Discussion This study in a large cohort of patients with cirrhosis by using 24-hour, solid state portable manometry showed in most individuals disturbances of cyclic fasting motility. Special motor patterns like RCCs during fasting and postprandial motility could be observed exclusively in the cirrhosis group, showing a significant correlation with severity of cirrhosis and the occurence of associated complications.

Intestinal malrotation: The role of small intestinal dysmotility in the cause of persistent symptoms

1991 ◽  
Vol 26 (5) ◽  
pp. 553-556 ◽  
Author(s):  
R.C. Coombs ◽  
R.G. Buick ◽  
P.G. Gornall ◽  
J.J. Corkery ◽  
I.W. Booth
Keyword(s):  
Intestinal Malrotation ◽  
Persistent Symptoms ◽  
Intestinal Dysmotility ◽  
Small Intestinal

Generalized Transit Delay on Wireless Motility Capsule Testing in Patients with Clinical Suspicion of Gastroparesis, Small Intestinal Dysmotility, or Slow Transit Constipation

2011 ◽  
Vol 56 (10) ◽  
pp. 2928-2938 ◽  
Author(s):  
Braden Kuo ◽  
Monthira Maneerattanaporn ◽  
Allen A. Lee ◽  
Jason R. Baker ◽  
Stephen M. Wiener ◽  
...  
Keyword(s):  
Clinical Suspicion ◽  
Slow Transit Constipation ◽  
Intestinal Dysmotility ◽  
Wireless Motility Capsule ◽  
Slow Transit ◽  
Small Intestinal ◽  
Transit Constipation ◽  
Transit Delay

Mo2059 Potential Role for Ileocecal Valve Dysfunction and Small Intestinal Dysmotility in Bacterial Overgrowth As Assessed by Wireless Motility Capsule

2013 ◽  
Vol 144 (5) ◽  
pp. S-730 ◽  
Author(s):  
Bani Chander Roland ◽  
Pankaj J. Pasricha ◽  
Maria Ciarleglio ◽  
Gerard E. Mullin ◽  
Ellen M. Stein ◽  
...  
Keyword(s):  
Potential Role ◽  
Bacterial Overgrowth ◽  
Ileocecal Valve ◽  
Valve Dysfunction ◽  
Intestinal Dysmotility ◽  
Wireless Motility Capsule ◽  
Small Intestinal

Irritable Bowel Syndrome and the Small Intestinal Microflora. What We Do Know?

2015 ◽  
Vol 53 (1) ◽  
pp. 105-109
Author(s):  
Ioana G. Moraru ◽  
A.G. Moraru ◽  
D.L. Dumitraşcu
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microflora ◽  
Bacterial Overgrowth ◽  
Small Intestinal Bacterial Overgrowth ◽  
Actual Knowledge ◽  
Intestinal Bacterial Overgrowth ◽  
Intestinal Dysmotility ◽  
Small Intestinal ◽  
Irritable Bowel ◽  
The Relationship

Abstract Irritable bowel syndrome, one of the most common functional gastro intestinal disorders all over the world is considered to have a multi factorial pathogenesis. Recently more and more studies are focusing on the changes that take place in the micro biota of patients with irritable bowel syndrome, underlining the bacterial role in this pathogenesis. As a consequence, bacterial overgrowth, along with intestinal dysmotility, altered brain-gut axis and genetic factors are considered part of this pathophysiology. This report intends to summarize the actual knowledge on irritable bowel syndrome and small intestinal bacterial overgrowth syndrome, from details on the epidemiology, clinical manifestation, pathophysiology, diagnosis, treatment to details on the relationship between these two syndromes.

scholarly journals The management of adult patients with severe chronic small intestinal dysmotility

Gut ◽  
2020 ◽  
Vol 69 (12) ◽  
pp. 2074-2092
Author(s):  
Jeremy M D Nightingale ◽  
Peter Paine ◽  
John McLaughlin ◽  
Anton Emmanuel ◽  
Joanne E Martin ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Functional Gastrointestinal Disorders ◽  
Adult Patients ◽  
Gastrointestinal Disorders ◽  
Psychosocial Issues ◽  
Management Guidelines ◽  
Intestinal Dysmotility ◽  
Small Intestinal ◽  
Enteric Myopathy ◽  
Enteral And Parenteral Nutrition

Adult patients with severe chronic small intestinal dysmotility are not uncommon and can be difficult to manage. This guideline gives an outline of how to make the diagnosis. It discusses factors which contribute to or cause a picture of severe chronic intestinal dysmotility (eg, obstruction, functional gastrointestinal disorders, drugs, psychosocial issues and malnutrition). It gives management guidelines for patients with an enteric myopathy or neuropathy including the use of enteral and parenteral nutrition.

scholarly journals Anti-inflammatory effects of sacral nerve stimulation: a novel spinal afferent and vagal efferent pathway

2020 ◽  
Vol 318 (4) ◽  
pp. G624-G634 ◽  
Author(s):  
Lei Tu ◽  
Payam Gharibani ◽  
Nina Zhang ◽  
Jieyun Yin ◽  
Jiande DZ Chen
Keyword(s):  
Brain Stem ◽  
Nerve Stimulation ◽  
Sacral Nerve Stimulation ◽  
Vagal Activity ◽  
Sacral Nerve ◽  
Efferent Pathway ◽  
Afferent Vagal ◽  
Anti Inflammatory ◽  
The Brain ◽  
Inflammatory Effect

Sacral nerve stimulation (SNS) was reported to improve 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rats. The aim of this study was to investigate whether the SNS anti-inflammatory effect is mediated via the local sacral splanchnic nerve or the spinal afferent-vagal efferent-colon pathway. Under general anesthesia, rats were administrated with TNBS intrarectally, and bipolar SNS electrodes were implanted unilaterally at S3. The sacral and vagal nerves were severed at different locations for the assessment of the neural pathway. SNS for 10 days improved colonic inflammation only in groups with intact afferent sacral nerve and vagus efferent nerve. SNS markedly increased acetylcholine and anti-inflammatory cytokines (IL-10) and decreased myeloperoxidase and proinflammatory cytokines (IL-2, IL-17A, and TNF-α) in colon tissues. SNS increased the number of c-fos-positive cells in the brain stem and normalized vagal activity measured by spectral analysis of heart rate variability. SNS exerts an anti-inflammatory effect on TNBS-induced colitis by enhancing vagal activity mediated mainly via the spinal afferent-brain stem-vagal efferent-colon pathway. NEW & NOTEWORTHY Our findings support that there is a possible sacral afferent-vagal efferent pathway that can transmit sacral nerve stimulation to the colon tissue. Sacral nerve stimulation can be carried out by spinal cord afferent to the brain stem and then by the vagal nerve (efferent) to the target organ.

Small intestinal dysmotility following abdominal irradiation in the rat small intestine

1998 ◽  
Vol 10 (5) ◽  
pp. 413-419 ◽  
Author(s):  
FRASER ◽  
FRISBY ◽  
BLACKSHAW ◽  
SCHIRMER ◽  
HOWARTH ◽  
...  
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Intestinal Dysmotility ◽  
Small Intestinal ◽  
Abdominal Irradiation
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