Volumetric analysis of small bowel motility in an unselected cohort of patients with Crohn’s disease

2020 ◽  
Vol 32 (10) ◽  
Author(s):  
Julia Dreja ◽  
Olle Ekberg ◽  
Peter Leander ◽  
Sven Månsson ◽  
Bodil Ohlsson
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Volumetric Analysis ◽  
Bowel Motility ◽  
Small Bowel Motility ◽  
Unselected Cohort

scholarly journals Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn’s disease patients—a validation study

2018 ◽  
pp. 20170914 ◽  
Author(s):  
Ruaridh M Gollifer ◽  
Alex Menys ◽  
Jesica Makanyanga ◽  
Carl AJ Puylaert ◽  
Frans M Vos ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Validation Study ◽  
Bowel Motility ◽  
Small Bowel Motility ◽  
Abdominal Symptoms

Quantification, validation, and follow-up of small bowel motility in Crohn's disease

2015 ◽  
Author(s):  
Juan J. Cerrolaza ◽  
Jennifer Q. Peng ◽  
Nabile M. Safdar ◽  
Laurie Conklin ◽  
Raymond Sze ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Bowel Motility ◽  
Small Bowel Motility

Differentiation between active and chronic Crohn's disease using MRI small-bowel motility examinations — Initial experience

2013 ◽  
Vol 68 (12) ◽  
pp. 1247-1253 ◽  
Author(s):  
S. Bickelhaupt ◽  
J.M. Froehlich ◽  
R. Cattin ◽  
N. Patuto ◽  
R. Tutuian ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Initial Experience ◽  
Bowel Motility ◽  
Small Bowel Motility

scholarly journals Gastrointestinal peptides and small-bowel hypomotility are possible causes for fasting and postprandial symptoms in active Crohn's disease

2019 ◽  
Vol 111 (1) ◽  
pp. 131-140
Author(s):  
Asseel Khalaf ◽  
Caroline L Hoad ◽  
Alex Menys ◽  
Adam Nowak ◽  
Shellie Radford ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Gut Hormones ◽  
Standard Test ◽  
Gut Peptides ◽  
Bowel Motility ◽  
Small Bowel Motility ◽  
Mri Scans ◽  
Glucagon Like Peptide 1

ABSTRACT Background Crohn's disease (CD) patients suffer postprandial aversive symptoms, which can lead to anorexia and malnutrition. Changes in the regulation of gut hormones and gut dysmotility are believed to play a role. Objectives This study aimed to investigate small-bowel motility and gut peptide responses to a standard test meal in CD by using MRI. Methods We studied 15 CD patients with active disease (age 36 ± 3 y; BMI 26 ± 1 kg/m 2) and 20 healthy volunteers (HVs; age 31 ± 3 years; BMI 24 ± 1 kg/m 2). They underwent baseline and postprandial MRI scans, symptom questionnaires, and blood sampling following a 400-g soup meal (204 kcal). Small-bowel motility, other MRI parameters, and glucagon-like peptide-1 (GLP-1), polypeptide YY (PYY), and cholecystokinin peptides were measured. Data are presented as means ± SEMs. Results HVs had significantly higher fasting motility indexes [106 ± 13 arbitrary units (a.u.)], compared with CD participants (70 ± 8 a.u.; P ≤ 0.05). Postprandial small-bowel water content showed a significant time by group interaction (P < 0.05), with CD participants showing higher levels from 210 min postprandially. Fasting concentrations of GLP-1 and PYY were significantly greater in CD participants, compared with HVs [GLP-1, CD 50 ± 8 µg/mL versus HV 13 ± 3 µg/mL (P ≤ 0.0001); PYY, CD 236 ± 16 pg/mL versus HV 118 ± 12 pg/mL (P ≤ 0.0001)]. The meal challenge induced a significant postprandial increase in aversive symptom scores (fullness, distention, bloating, abdominal pain, and sickness) in CD participants compared with HVs (P ≤ 0.05). Conclusions The decrease in fasting small-bowel motility noted in CD participants can be ascribed to the increased fasting gut peptides. A better understanding of the etiology of aversive symptoms in CD will facilitate identification of better therapeutic targets to improve nutritional status. This trial was registered at clinicaltrials.gov as NCT03052465.

Crohn's disease: small bowel motility impairment correlates with inflammatory-related markers C-reactive protein and calprotectin

2013 ◽  
Vol 25 (6) ◽  
pp. 467-e363 ◽  
Author(s):  
S. Bickelhaupt ◽  
S. Pazahr ◽  
N. Chuck ◽  
I. Blume ◽  
J. M. Froehlich ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
C Reactive Protein ◽  
Bowel Motility ◽  
Small Bowel Motility ◽  
Reactive Protein

scholarly journals Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in Crohn's disease

2015 ◽  
Vol 42 (3) ◽  
pp. 343-355 ◽  
Author(s):  
A. A. Plumb ◽  
A. Menys ◽  
E. Russo ◽  
D. Prezzi ◽  
G. Bhatnagar ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Medical Therapy ◽  
Resonance Imaging ◽  
Bowel Motility ◽  
Small Bowel Motility ◽  
Sensitive Marker

Quantitative assessment of small bowel motility in patients with Crohn's disease using dynamic MRI

2015 ◽  
Vol 27 (6) ◽  
pp. 841-848 ◽  
Author(s):  
M. L. Hahnemann ◽  
F. Nensa ◽  
S. Kinner ◽  
J. Köhler ◽  
G. Gerken ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Quantitative Assessment ◽  
Dynamic Mri ◽  
Bowel Motility ◽  
Small Bowel Motility

scholarly journals Automated versus subjective assessment of spatial and temporal MRI small bowel motility in Crohn's disease

2019 ◽  
Vol 74 (10) ◽  
pp. 814.e9-814.e19 ◽  
Author(s):  
R.M. Gollifer ◽  
A. Menys ◽  
A. Plumb ◽  
K. Mengoudi ◽  
C.A.J. Puylaert ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Subjective Assessment ◽  
Bowel Motility ◽  
Small Bowel Motility
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