bowel motility
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2022 ◽  
Vol 7 (2) ◽  
pp. 83-88
Author(s):  
Mandana Mansour Ghanaei ◽  
Effat Ebadollahi Nodeh ◽  
Seyed Mohammah Asghari Ghalebin ◽  
Seyedeh Hajar Sharami ◽  
Katayoun Haryalchi ◽  
...  

Author(s):  
Phil G Dinning ◽  
Lukasz Wiklendt ◽  
Marcello C. Costa ◽  
Simon J. H. Brookes ◽  
Maureen Amicangelo ◽  
...  

Bisacodyl is a stimulant laxative often used in manometric studies of pediatric constipation to determine if it can initiate propulsive high amplitude propagating contractions. While the effects of bisacodyl infusion on colonic motility are well described, the effects of the drug on other regions of the gut after colonic infusion are not known. The aim of the present study was to characterize the effects of bisacodyl on both colonic and small bowel motility. Methods. Twenty seven children (9.3 + 1.2 years) undergoing simultaneous high resolution antroduodenal and colonic manometry were included. Small bowel and colonic motor patterns were assessed prior to and after colonic infusion of bisacodyl. Patients were divided into 2 groups; responders and non-responders based on the presence of high amplitude propagating contractions (HAPC) after bisacodyl infusion. Results. Nineteen patients were responders. 188 post-bisacodyl HAPCs were identified with a mean count of 10.4 ± 5.5 (range, 3 -22), at a frequency of 0.6 ± 0.2/min and mean amplitude of 119.8 ± 23.6 mmHg.No motor patterns were induced in the small bowel. However, in the 19 responders the onset of HAPCs was associated with a significant decrease in small bowel contractile activity. In the non-responders there was no detectable change in small bowel motility after bisacodyl infusion. Conclusion. Bisacodyl induced HAPCs are associated with a significant reduction in small bowel motility probably mediated by extrinsic sympathetic reflex pathways. This inhibition is potentially related to rectal distension, caused by the HAPC anal propulsion of colonic content.


2021 ◽  
Vol 160 (6) ◽  
pp. S-494
Author(s):  
Noriaki Manabe ◽  
Ryo Katsumata ◽  
Maki Ayaki ◽  
Minoru Fujita ◽  
Tomoari Kamada ◽  
...  

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1028
Author(s):  
Jeong Pil Han ◽  
Jeong Hyeon Lee ◽  
Geon Seong Lee ◽  
Ok Jae Koo ◽  
Su Cheong Yeom

Neuronal nitric oxide synthase (nNOS) has various roles as a neurotransmitter. However, studies to date have produced insufficient data to fully support the correlation between nNOS and bowel motility. This study aimed to investigate the correlation between nNOS expression and gastrointestinal (GI) tract motility using a stress-induced neonatal maternal separation (NMS) mouse model. In this study, we generated a genetically modified mouse with the HiBiT sequence knock-in into the nNOS gene using CRISPR/Cas9 for analyzing accurate nNOS expression. nNOS expression was measured in the stomach, small intestine, large intestine, adrenal gland, and hypothalamus tissues after establishing the NMS model. The NMS model exhibited a significant increase in nNOS expression in large intestine, adrenal gland, and hypothalamus. Moreover, a significant positive correlation was observed between whole gastrointestinal transit time and the expression level of nNOS. We reasoned that NMS induced chronic stress and consequent nNOS activation in the hypothalamic-pituitary-adrenal (HPA) axis, and led to an excessive increase in intestinal motility in the lower GI tract. These results demonstrated that HiBiT is a sensitive and valuable tool for analyzing in vivo gene activation, and nNOS could be a biomarker of the HPA axis-linked lower intestinal tract dysfunction.


2021 ◽  
Vol 15 (1) ◽  
pp. 48-55
Author(s):  
Djunizar Djamaludin ◽  
Eka Yudha Chrisanto

Xylitol gum chewing to achieve early postoperative restoration of bowel motility after surgery under general anesthesiaBackground: The problem that is often encountered in the use of general anesthesia in major surgery is the Post-Operative Ileus (POI). POI is a temporary loss of gastrointestinal propulsion activity characterized by no sounding of bowel sounds and abdominal discomfort and distension. Providing nutrition oral or enteral  when bowel sounds begin to sound has a weakness where it was reported that in this intervention the incidence of bloating, nausea and vomiting was mostly experienced by patients who were intolerant of the presence of food in their stomach.Purpose: Knowing the effect of Xylitol gum chewing to achieve early postoperative restoration of bowel motility after surgery under general anesthesiaMethod: A quasi-experimental method with pre-test and post-test in two groups of 20 patients as participants at A. Dadi Tjokro Dipo Hospital Bandar Lampung City recruited and taken by purposive sampling technique, 10 participants as intervention group (treat by chewing xylitol gum) and other of 10 participants as control group.Results: Finding that by a treat of Xylitol gum chewing in postoperative restoration of bowel motility after surgery under general anesthesia took after 2.3 hours while the patients who did not chew xylitol gum occurred 6.8 hours. T-Test showed that p-value was 0.00 that indicated the p-value < 0.05.Conclusion: There was a difference in the occurring time of the intestine motility between control and experiment groups. It is gained that difference is 4.39 hours with p-value = 0.00 which indicated p < 0.05, that there was an effect of chewing gum containing xylitol on the occurrence of post-operative intestine motility after general anesthesia surgery at A Dadi Tjokor Dipo Hospital of Bandar Lampung City. The present study suggests chewing gum is an alternative method to stimulate intestine motility for early post-operation feeding as a low-cost, safe, and tolerable treatment when without contra indication.Keywords:  Xylitol gum chewing; Postoperative restoration; Bowel motility; Surgery; General anesthesiaPendahuluan: Masalah yang sering dijumpai dalam penggunaan general anestesi pada pembedahan mayor yaitu Post-Operative Ileus (POI). POI adalah hilangnya aktivitas daya dorong saluran cerna untuk sementara yang ditandai dengan tidak terdengarnya bising usus dan rasa tidak nyaman serta distensi abdomen. Memberikan nutrisi secara oral maupun enteral pada saat bising usus mulai terdengar merupakan memiliki kelemahan dimana dilaporkan bahwa pada intervensi ini kejadian kembung, mual dan muntah paling banyak dialami oleh pasien yang tidak toleran terhadap adanya makanan dalam lambungnyaTujuan: Diketahuinya pengaruh mengunyah permen yang mengandung xylitol terhadap timbulnya motilitas usus pada pasien pasca operasi dengan general anestesi.Metode: Penelitian eksperimen semu dengan pre-test dan post-test group. Jumlah pasien yang akan menjalani operasi elektif dengan menggunakan anestesi umum sebanyak 20 pasien di RSUD A. Dadi Tjokro Dipo Kota Bandar Lampung. Sampel diambil dengan teknik purposive sampling, 10 pasien pasca operasi mengunyah permen karet xylitol dan 10 pasien pasca operasi tidak mengunyah permen karet xylitol.Hasil: Didapatkan motilitas usus timbul 2,3 jam setelah mengunyah permen karet dan 6,8 jam bila tidak mengunyah. Hasil uji t-test  didapatkan bahwa p value=0,00 yang berarti nilai p<0,05.Simpulan: Terdapat perbedaan waktu timbulnya motilitas usus pada kelompok kontrol dan kelompok eskperimen sebesar 4,39 jam dan didapatkan nilai p=0,00 yang berarti nilai p<0,05 sehingga Ho ditolak. Oleh karena itu dapat disimpulkan bahwa ada pengaruh pemberian permen karet yang mengandung xylitol terhadap timbulnya motilitas usus pasca operasi dengan general anestesi di RSUD A. Dadi Tjokro Dipo Kota Bandar Lampung. Penelitian ini menunjukkan bahwa mengunyah permen karet adalah metode alternatif untuk merangsang motilitas usus untuk pemberian makan pasca operasi awal sebagai pengobatan yang berbiaya rendah, aman, dan dapat ditoleransi..


2021 ◽  
Author(s):  
Neele S Dellschaft ◽  
Christabella Ng ◽  
Caroline Hoad ◽  
Luca Marciani ◽  
Robin Spiller ◽  
...  

AbstractCystic fibrosis (CF) is a genetic disease affecting mucosal secretions. Most patients experience digestive symptoms, but the mechanisms are incompletely understood. Here we explore causes and consequences of slower gastrointestinal transit using magnetic resonance imaging (MRI).Twelve people with CF and 12 healthy controls, matched for age and gender, underwent MRI scans both fasted and after standardised meals over a period of 6.5 hours. Images were assessed for small bowel motility, longitudinal relaxation time (T1) of ascending colon chyme, chyme texture and appearance of the colon wall.Small bowel motility scores were significantly lower in CF than in healthy controls in the fasting state (CF median 40 arbitrary units IQR [31, 46] vs Control 86 a.u. [52, 106], P=0.034). This difference was less pronounced postprandially. Furthermore, ascending colon chyme T1 was lower in CF than in controls (CF 0.59 s [0.38, 0.77] vs Control 0.79 s [0.55, 1.31], P=0.010). The difference in texture between small bowel and colon chyme, seen in health, was diminished in CF (difference in Haralick contrast 0.90 a.u. [0.38, 1.67] vs Control 2.11 a.u. [0.71, 3.30], P=0.010). Ascending colon mucosa in CF participants had an abnormal appearance compared to controls (Score 1-3, CF 2 [1, 3] vs Controls 1 [1, 1], P=0.019).Reduced small bowel motility and water content of ascending colon chyme are consistent with slower transit and constipation. MRI provides unique insights into chyme texture in the small bowel (suggesting bacterial overgrowth) and the appearance of the colon mucosa (suggesting altered mucus) in CF.Key point summary-People with cystic fibrosis (CF) have intrusive digestive symptoms and severe gut complications, but mechanisms are incompletely understood.-In this study, 12 people with CF were compared to healthy controls, undergoing repeated MRI scans before and after standardised meals.-Fasted small bowel motility is reduced in people with CF, consistent with slower transit. In addition, a reduced colonic chyme water content and abnormal appearance of small bowel and colonic chyme as well as colonic mucosa suggest small bowel bacterial overgrowth, fat malabsorption and abnormal mucus production-These MRI outcomes hold promise in the assessment of therapeutic interventions.


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