scholarly journals Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in Crohn's disease

2015 ◽  
Vol 42 (3) ◽  
pp. 343-355 ◽  
Author(s):  
A. A. Plumb ◽  
A. Menys ◽  
E. Russo ◽  
D. Prezzi ◽  
G. Bhatnagar ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Medical Therapy ◽  
Resonance Imaging ◽  
Bowel Motility ◽  
Small Bowel Motility ◽  
Sensitive Marker

scholarly journals Magnetic Resonance Imaging Predicts Histopathological Composition of Ileal Crohn’s Disease

2018 ◽  
Vol 12 (6) ◽  
pp. 718-729 ◽  
Author(s):  
Mathilde Wagner ◽  
Huaibin Mabel Ko ◽  
Manjil Chatterji ◽  
Cecilia Besa ◽  
Joana Torres ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Smooth Muscle ◽  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Wall Thickness ◽  
Muscle Hypertrophy ◽  
Resonance Imaging ◽  
Post Contrast

Abstract Background and Aims Recently, smooth muscle hypertrophy has been suggested to be a contributor to small bowel lesions secondary to Crohn’s disease [CD], in addition to inflammation and fibrosis. Here, we assess the value of magnetic resonance imaging [MRI] for the characterisation of histopathological tissue composition of small bowel CD, including inflammation, fibrosis, and smooth muscle hypertrophy. Methods A total of 35 consecutive patients [male/female 17/18, mean age 33 years] with ileal CD, who underwent small bowel resection and a preoperative contrast-enhanced MRI examination within 1 month before surgery, were retrospectively included. Image assessment included qualitative [pattern/degree of enhancement, presence of ulcerations/fistulas/abscesses] and quantitative parameters [wall thickness on T2/T1-weighted images [WI], enhancement ratios, apparent diffusion coefficient [ADC], Clermont and Magnetic Resonance Index of Activity [MaRIA] scores). MRI parameters were compared with histopathological findings including active inflammation, collagen deposition, and muscle hypertrophy using chi square/Fisher or Mann-Whitney tests and univariate/multivariate logistic/linear regression analyses. Results Forty ileal segments were analysed in 35 patients. Layered pattern at early-post-contrast phase was more prevalent (odds ratio [OR] = 8; p = 0.008), ADC was significantly lower [OR = 0.005; p = 0.022], and MaRIA score was significantly higher [OR = 1.125; p = 0.022] in inflammation grades 2–3 compared with grade 1. Wall thickness on T2WI was significantly increased [OR = 1.688; p = 0.043], and fistulas [OR = 14.5; p = 0.017] were more prevalent in segments with disproportionately increased muscle hypertrophy versus those with disproportionately increased fibrosis. MaRIA/Clermont scores, wall thickness on T1WI and T2WI, and ADC were all significantly correlated with degree of muscular hypertrophy. Conclusions MRI predicts the degree of inflammation, and can distinguish prominent muscle hypertrophy from prominent fibrosis in ileal CD with reasonable accuracy (area under receiver operating characteristic curve [AUROC] > 0.7).

Utility of Magnetic Resonance Imaging in Small Bowel Crohn’s Disease

2007 ◽  
Vol 133 (2) ◽  
pp. 385-390 ◽  
Author(s):  
Diego R. Martin ◽  
Thomas Lauenstein ◽  
Shanthi V. Sitaraman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Crohn’S Disease ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Resonance Imaging

scholarly journals Acceleration of small bowel motility after oral administration of dai-kenchu-to (TJ-100) assessed by cine magnetic resonance imaging

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191044 ◽  
Author(s):  
Akitoshi Inoue ◽  
Akira Furukawa ◽  
Hiroshi Yamamoto ◽  
Shinichi Ohta ◽  
Nguyen Dai Hung Linh ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
Oral Administration ◽  
Cine Magnetic Resonance Imaging ◽  
Resonance Imaging ◽  
Bowel Motility ◽  
Small Bowel Motility
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