Decreased smooth muscle function, peristaltic activity, and gastrointestinal transit in dystrophic ( mdx ) mice

2020 ◽  
Author(s):  
Kulpreet Singh ◽  
Gurpreet Randhwa ◽  
Fadi N. Salloum ◽  
John R. Grider ◽  
Karnam S. Murthy
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Gastrointestinal Transit ◽  
Mdx Mice ◽  
Peristaltic Activity ◽  
Smooth Muscle Function

scholarly journals Altered Contraction Phenotype and Smooth Muscle Function in the Intestine of Dystrophin‐Deficient ( mdx ) Mice

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Sunila Mahavadi ◽  
Aditya Gorti ◽  
Roushini Manjunath ◽  
Gurpreet Randhawa ◽  
Kulpreet Singh ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Mdx Mice ◽  
Smooth Muscle Function

SMALL BOWEL ISCHEMIA/REPERFUSION (II/R) ALTERS COLONIC SMOOTH MUSCLE FUNCTION.

Shock ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. 13
Author(s):  
DT Dempsey ◽  
BS Myers ◽  
JP Ryan ◽  
J Carroll ◽  
SI Myers
Keyword(s):  
Smooth Muscle ◽  
Small Bowel ◽  
Muscle Function ◽  
Ischemia Reperfusion ◽  
Bowel Ischemia ◽  
Smooth Muscle Function

Effect of Flush-Perfusion on Vascular Endothelial and Smooth Muscle Function

1997 ◽  
Vol 64 (4) ◽  
pp. 1075-1081 ◽  
Author(s):  
Richard Ingemansson ◽  
Algimantas Budrikis ◽  
Ramunas Bolys ◽  
Trygve Sjöberg ◽  
Stig Steen
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Vascular Endothelial ◽  
Smooth Muscle Function

scholarly journals Effects of Scleroderma Antibodies and Pooled Human Immunoglobulin on Anal Sphincter and Colonic Smooth Muscle Function

2012 ◽  
Vol 143 (5) ◽  
pp. 1308-1318 ◽  
Author(s):  
Jagmohan Singh ◽  
Sidney Cohen ◽  
Vaibhav Mehendiratta ◽  
Fabian Mendoza ◽  
Sergio A. Jimenez ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Anal Sphincter ◽  
Muscle Function ◽  
Human Immunoglobulin ◽  
Smooth Muscle Function

Detrimental Effects of Nearby Construction Activity on Endothelial and Vascular Smooth Muscle Function in Cerebral Arteries of Sprague‐Dawley (S‐D) Rats

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Julian H. Lombard ◽  
Maia Terashvili ◽  
Kaleigh Kozak ◽  
Alison Gifford ◽  
Nnamdi Uche ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Cerebral Arteries ◽  
Sprague Dawley ◽  
Smooth Muscle Function ◽  
Construction Activity

scholarly journals Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility

2019 ◽  
Vol 141 (3) ◽  
Author(s):  
Alexander W. Caulk ◽  
Jay D. Humphrey ◽  
Sae-Il Murtada
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Contractile Function ◽  
Contractile Activity ◽  
Comparison Of Methods ◽  
Axial Stretch ◽  
Smooth Muscle Function ◽  
In Vivo Loading

Vascular smooth muscle cells (VSMCs) can regulate arterial mechanics via contractile activity in response to changing mechanical and chemical signals. Contractility is traditionally evaluated via uniaxial isometric testing of isolated rings despite the in vivo environment being very different. Most blood vessels maintain a locally preferred value of in vivo axial stretch while subjected to changes in distending pressure, but both of these phenomena are obscured in uniaxial isometric testing. Few studies have rigorously analyzed the role of in vivo loading conditions in smooth muscle function. Thus, we evaluated effects of uniaxial versus biaxial deformations on smooth muscle contractility by stimulating two regions of the mouse aorta with different vasoconstrictors using one of three testing protocols: (i) uniaxial isometric testing, (ii) biaxial isometric testing, and (iii) axially isometric plus isobaric testing. Comparison of methods (i) and (ii) revealed increased sensitivity and contractile capacity to potassium chloride and phenylephrine (PE) with biaxial isometric testing, and comparison of methods (ii) and (iii) revealed a further increase in contractile capacity with isometric plus isobaric testing. Importantly, regional differences in estimated in vivo axial stretch suggest locally distinct optimal biaxial configurations for achieving maximal smooth muscle contraction, which can only be revealed with biaxial testing. Such differences highlight the importance of considering in vivo loading and geometric configurations when evaluating smooth muscle function. Given the physiologic relevance of axial extension and luminal pressurization, we submit that, when possible, axially isometric plus isobaric testing should be employed to evaluate vascular smooth muscle contractile function.

scholarly journals Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactions

2009 ◽  
Vol 297 (4) ◽  
pp. G716-G725 ◽  
Author(s):  
Xuan-Zheng Shi ◽  
Sushil K. Sarna
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Response ◽  
Muscle Function ◽  
Contractile Response ◽  
Enteric Neurons ◽  
Muscle Dysfunction ◽  
Spontaneous Release ◽  
Circular Smooth Muscle ◽  
Smooth Muscle Function ◽  
Smooth Muscle Dysfunction

We tested the hypothesis that spontaneous release of vasoactive intestinal peptide (VIP) from enteric neurons maintains homeostasis in smooth muscle function in mild inflammatory insults and that infusion of exogenous VIP has therapeutic effects on colonic smooth muscle dysfunction in inflammation. In vitro experiments were performed on human colonic circular smooth muscle tissues and in vivo on rats. The incubation of human colonic circular smooth muscle strips with TNF-α suppressed their contractile response to ACh and the expression of the pore-forming α1C subunit of Cav1.2 channels. VIP reversed both effects by blocking the translocation of NF-κB to the nucleus and its binding to the κB recognition sites on hα1C1b promoter. The translocation of NF-κB was inhibited by blocking the degradation of IκBβ. Induction of inflammation by a subthreshold dose of 17 mg/kg trinitrobenzene sulfonic acid (TNBS) in rats moderately decreased muscularis externa concentration of VIP, and it had little effect on the contractile response of circular smooth muscle strips to ACh. The blockade of VIP and pituitary adenylate cyclase-activating peptide receptors 1/2 during mild inflammatory insult significantly worsened the suppression of contractility and the inflammatory response. The induction of more severe inflammation by 68 mg/kg TNBS induced marked suppression of colonic circular muscle contractility and decrease in serum VIP. Exogenous infusion of VIP by an osmotic pump reversed these effects. We conclude that the spontaneous release of VIP from the enteric motor neurons maintains homeostasis in smooth muscle function in mild inflammation by blocking the activation of NF-κB. The infusion of exogenous VIP mitigates colonic inflammatory response and smooth muscle dysfunction.

Alterations in Enteric Nerve and Smooth-Muscle Function in Inflammatory Bowel Diseases

1997 ◽  
Vol 3 (1) ◽  
pp. 38-48 ◽  
Author(s):  
Stephen M. Collins ◽  
Gert Van Assche ◽  
Cory Hogaboam
Keyword(s):  
Smooth Muscle ◽  
Inflammatory Bowel Diseases ◽  
Muscle Function ◽  
Smooth Muscle Function ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Inositol Trisphosphate and Smooth Muscle Function

2017 ◽  
pp. 413-445
Author(s):  
R.F. Coburn ◽  
H. Matsumoto ◽  
C. B. Baron
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Inositol Trisphosphate ◽  
Smooth Muscle Function

Inflammation Alters Smooth Muscle Function in the Gut: Studies on the Nematode-Infected Rat

2020 ◽  
pp. 35-44
Author(s):  
S.M. Collins ◽  
D.L. Vermillion ◽  
J.D. Huizinga ◽  
M.J. Muller
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Smooth Muscle Function
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