Detrimental Effects of Nearby Construction Activity on Endothelial and Vascular Smooth Muscle Function in Cerebral Arteries of Sprague‐Dawley (S‐D) Rats

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Julian H. Lombard ◽  
Maia Terashvili ◽  
Kaleigh Kozak ◽  
Alison Gifford ◽  
Nnamdi Uche ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Cerebral Arteries ◽  
Sprague Dawley ◽  
Smooth Muscle Function ◽  
Construction Activity

scholarly journals Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility

2019 ◽  
Vol 141 (3) ◽  
Author(s):  
Alexander W. Caulk ◽  
Jay D. Humphrey ◽  
Sae-Il Murtada
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Contractile Function ◽  
Contractile Activity ◽  
Comparison Of Methods ◽  
Axial Stretch ◽  
Smooth Muscle Function ◽  
In Vivo Loading

Vascular smooth muscle cells (VSMCs) can regulate arterial mechanics via contractile activity in response to changing mechanical and chemical signals. Contractility is traditionally evaluated via uniaxial isometric testing of isolated rings despite the in vivo environment being very different. Most blood vessels maintain a locally preferred value of in vivo axial stretch while subjected to changes in distending pressure, but both of these phenomena are obscured in uniaxial isometric testing. Few studies have rigorously analyzed the role of in vivo loading conditions in smooth muscle function. Thus, we evaluated effects of uniaxial versus biaxial deformations on smooth muscle contractility by stimulating two regions of the mouse aorta with different vasoconstrictors using one of three testing protocols: (i) uniaxial isometric testing, (ii) biaxial isometric testing, and (iii) axially isometric plus isobaric testing. Comparison of methods (i) and (ii) revealed increased sensitivity and contractile capacity to potassium chloride and phenylephrine (PE) with biaxial isometric testing, and comparison of methods (ii) and (iii) revealed a further increase in contractile capacity with isometric plus isobaric testing. Importantly, regional differences in estimated in vivo axial stretch suggest locally distinct optimal biaxial configurations for achieving maximal smooth muscle contraction, which can only be revealed with biaxial testing. Such differences highlight the importance of considering in vivo loading and geometric configurations when evaluating smooth muscle function. Given the physiologic relevance of axial extension and luminal pressurization, we submit that, when possible, axially isometric plus isobaric testing should be employed to evaluate vascular smooth muscle contractile function.

scholarly journals Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysis

Diabetologia ◽  
2013 ◽  
Vol 56 (10) ◽  
pp. 2122-2133 ◽  
Author(s):  
David Montero ◽  
Guillaume Walther ◽  
Antonia Pérez-Martin ◽  
Nestor Vicente-Salar ◽  
Enrique Roche ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Meta Analysis ◽  
Smooth Muscle Function

Effects of licorice derivatives on vascular smooth muscle function

Life Sciences ◽  
1996 ◽  
Vol 60 (3) ◽  
pp. 207-214 ◽  
Author(s):  
Andrew S. Brem ◽  
Robert B. Bina ◽  
Nicholas Hill ◽  
Chris Alia ◽  
David J. Morris
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Smooth Muscle Function

scholarly journals Aldosterone Impairs Vascular Smooth Muscle Function: From Clinical to Bench Research

2015 ◽  
Vol 100 (11) ◽  
pp. 4339-4347 ◽  
Author(s):  
Chia-Hung Chou ◽  
Ying-Hsien Chen ◽  
Chi-Sheng Hung ◽  
Yi-Yao Chang ◽  
Yu-Lin Tzeng ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
Smooth Muscle Function

scholarly journals Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase

2012 ◽  
Vol 16 (4) ◽  
pp. 462-472 ◽  
Author(s):  
Christopher J. Pelham ◽  
Pimonrat Ketsawatsomkron ◽  
Séverine Groh ◽  
Justin L. Grobe ◽  
Willem J. de Lange ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Arterial Blood Pressure ◽  
Muscle Function ◽  
Rho Kinase ◽  
Arterial Blood ◽  
Smooth Muscle Function ◽  
Cullin 3

Intracellular pH as a Determinant of Vascular Smooth Muscle Function

2006 ◽  
Vol 43 (3) ◽  
pp. 238-250 ◽  
Author(s):  
Ichiro Wakabayashi ◽  
Michael Poteser ◽  
Klaus Groschner
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Intracellular Ph ◽  
Muscle Function ◽  
Smooth Muscle Function

scholarly journals Vascular Dysfunction Predicts Future Deterioration of Left Ventricular Ejection Fraction in Patients with Heart Failure with Mildly Reduced Ejection Fraction

2021 ◽  
Vol 10 (24) ◽  
pp. 5980
Author(s):  
Shinji Kishimoto ◽  
Tatsuya Maruhashi ◽  
Masato Kajikawa ◽  
Takahiro Harada ◽  
Takayuki Yamaji ◽  
...  
Keyword(s):  
Heart Failure ◽  
Smooth Muscle ◽  
Ejection Fraction ◽  
Vascular Smooth Muscle ◽  
Endothelial Function ◽  
Muscle Function ◽  
Vascular Dysfunction ◽  
Left Ventricular Ejection ◽  
Reduced Ejection Fraction ◽  
Smooth Muscle Function

The purpose of this study was to evaluate whether heart failure with mildly reduced ejection fraction (HFmrEF) is associated with vascular dysfunction and whether vascular function predicts future deterioration of LVEF in patients with HFmrEF. We evaluated endothelial function assessed by flow-mediated vasodilation (FMD) and vascular smooth muscle function assessed by nitroglycerine-induced vasodilation (NID) in 69 patients with HFmrEF and 426 patients without HF and evaluated the future deterioration of LVEF, defined as a decrease in LVEF to <40%, in 39 patients with HFmrEF for up to 3 years. Both FMD and NID were significantly lower in patients with HFmrEF than in patients without HF. We categorized patients into two groups based on low tertiles of NID: a low group (NID of <7.0%) and an intermediate and high group (NID of ≥7.0%). There were significant differences between the Kaplan–Meier curves for the deterioration of LVEF in the two groups (p < 0.01). Multivariate Cox proportional hazard analysis revealed that NID of <7.0% was an independent predictor of future deterioration of LVEF in patients with HFmrEF. Both endothelial function and vascular smooth muscle function are impaired in patients with HFmrEF compared with those in patients without HF. In addition, low NID of <7.0% predicts future deterioration of LVEF.

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