Motor patterns in the proximal and distal mouse colon which underlie formation and propulsion of feces

2021 ◽  
Author(s):  
Marcello Costa ◽  
Lauren J. Keightley ◽  
Timothy J. Hibberd ◽  
Lukasz Wiklendt ◽  
Phil G. Dinning ◽  
...  
Keyword(s):  
Motor Patterns ◽  
Mouse Colon ◽  
Distal Mouse

The secretory KCa1.1 channel localises to crypts of distal mouse colon: functional and molecular evidence

2011 ◽  
Vol 462 (5) ◽  
pp. 745-752 ◽  
Author(s):  
Mads V. Sørensen ◽  
Anne B. Strandsby ◽  
Casper K. Larsen ◽  
Helle A. Praetorius ◽  
Jens Leipziger
Keyword(s):  
Molecular Evidence ◽  
Mouse Colon ◽  
Distal Mouse

scholarly journals Characterization of alternating neurogenic motor patterns in mouse colon

2020 ◽  
Author(s):  
Marcello Costa ◽  
Lauren J. Keightley ◽  
Timothy J. Hibberd ◽  
Lukasz Wiklendt ◽  
David J. Smolilo ◽  
...  
Keyword(s):  
Motor Patterns ◽  
Mouse Colon

Neurogenic and myogenic motor activity in the colon of the guinea pig, mouse, rabbit, and rat

2013 ◽  
Vol 305 (10) ◽  
pp. G749-G759 ◽  
Author(s):  
M. Costa ◽  
K. N. Dodds ◽  
L. Wiklendt ◽  
N. J. Spencer ◽  
S. J. H. Brookes ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Rat Colon ◽  
Muscarinic Agonist ◽  
Motor Patterns ◽  
Video Recordings ◽  
Mouse Colon ◽  
Myogenic Activity ◽  
Peristaltic Contractions ◽  
Subsequent Addition ◽  
Type Contraction

Gastrointestinal motility involves interactions between myogenic and neurogenic processes intrinsic to the gut wall. We have compared the presence of propagating myogenic contractions of the isolated colon in four experimental animals (guinea pig, mouse, rabbit, and rat), following blockade of enteric neural activity. Isolated colonic preparations were distended with fluid, with the anal end either closed or open. Spatiotemporal maps of changes in diameter were constructed from video recordings. Distension-induced peristaltic contractions were abolished by tetrodotoxin (TTX; 0.6 μM) in all animal species. Subsequent addition of carbachol (0.1–1 μM) did not evoke myogenic motor patterns in the mouse or guinea pig, although some activity was observed in rabbit and rat colon. These myogenic contractions propagated both orally and anally and differed from neurogenic propagating contractions in their frequency, extent of propagation, and polarity. Niflumic acid (300 μM), used to block myogenic activity, also blocked neural peristalsis and thus cannot be used to discriminate between these mechanisms. In all species, except the mouse colon, small myogenic “ripple” contractions were revealed in TTX, but in both rat and rabbit an additional, higher-frequency ripple-type contraction was superimposed. Following blockade of enteric nerve function, a muscarinic agonist can evoke propulsive myogenic peristaltic contractions in isolated rabbit and rat colon, but not in guinea pig or mouse colon. Marked differences between species exist in the ability of myogenic mechanisms to propel luminal content, but in all species there is normally a complex interplay between neurogenic and myogenic processes.

Discrepancies between c-Kit positive and Ano1 positive ICC-SMP in theW/Wvand wild-type mouse colon; relationships with motor patterns and calcium transients

2014 ◽  
Vol 26 (9) ◽  
pp. 1298-1310 ◽  
Author(s):  
Xuan-Yu Wang ◽  
Ji-Hong Chen ◽  
Kongling Li ◽  
Yong F. Zhu ◽  
George W. J. Wright ◽  
...  
Keyword(s):  
Wild Type Mouse ◽  
Calcium Transients ◽  
Wild Type ◽  
Motor Patterns ◽  
Mouse Colon

Swallow Pattern Generator Reconfiguration of the Respiratory Neural Network

2009 ◽  
Vol 18 (1) ◽  
pp. 3-12
Author(s):  
Andrea Vovka ◽  
Paul W. Davenport ◽  
Karen Wheeler-Hegland ◽  
Kendall F. Morris ◽  
Christine M. Sapienza ◽  
...  
Keyword(s):  
Behavioral Control ◽  
Upper Airway ◽  
Pattern Generator ◽  
Breathing Patterns ◽  
Motor Patterns ◽  
Control Assembly ◽  
Pharyngeal Swallow ◽  
Laryngeal Vestibule ◽  
Lower Airways ◽  
Swallow Apnea

Abstract When the nasal and oral passages converge and a bolus enters the pharynx, it is critical that breathing and swallow motor patterns become integrated to allow safe passage of the bolus through the pharynx. Breathing patterns must be reconfigured to inhibit inspiration, and upper airway muscle activity must be recruited and reconfigured to close the glottis and laryngeal vestibule, invert the epiglottis, and ultimately protect the lower airways. Failure to close and protect the glottal opening to the lower airways, or loss of the integration and coordination of swallow and breathing, increases the risk of penetration or aspiration. A neural swallow central pattern generator (CPG) controls the pharyngeal swallow phase and is located in the medulla. We propose that this swallow CPG is functionally organized in a holarchical behavioral control assembly (BCA) and is recruited with pharyngeal swallow. The swallow BCA holon reconfigures the respiratory CPG to produce the stereotypical swallow breathing pattern, consisting of swallow apnea during swallowing followed by prolongation of expiration following swallow. The timing of swallow apnea and the duration of expiration is a function of the presence of the bolus in the pharynx, size of the bolus, bolus consistency, breath cycle, ventilatory state and disease.

Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus

2001 ◽  
Vol 120 (5) ◽  
pp. A296-A296
Author(s):  
C DAI ◽  
G STEVENL ◽  
M GEE ◽  
W LEE ◽  
H LEE ◽  
...  
Keyword(s):  
Tumor Angiogenesis ◽  
Colon Tumor ◽  
Mouse Colon

Activation of proteinase-activated receptor-2 by the peptide SLIGRL or trypsin induces inflammation of mouse colon

2001 ◽  
Vol 120 (5) ◽  
pp. A725-A725 ◽  
Author(s):  
N CENAC ◽  
R GARCIAVILLAR ◽  
L MAZELIN ◽  
A COELHO ◽  
J MORE ◽  
...  
Keyword(s):  
Mouse Colon

Celecoxib Targeted Therapy Attenuates Mouse Colon Carcinogenesis through Modulation of Expression Patterns of Cancer Stem Cells

2019 ◽  
Vol 38 (4) ◽  
pp. 329-343
Author(s):  
Elsayed I. Salim ◽  
Magdy E. Mahfouz ◽  
Jin Seok Kang ◽  
Mona M. Hegazi ◽  
Hager M. Helmy ◽  
...  
Keyword(s):  
Stem Cells ◽  
Targeted Therapy ◽  
Cancer Stem Cells ◽  
Expression Patterns ◽  
Colon Carcinogenesis ◽  
Mouse Colon
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