Centrally Administered Neuropeptide‐S Alleviates Gastrointestinal Dysmotility Induced by Neonatal Maternal Separation

2021 ◽  
Author(s):  
Mehmet Bülbül ◽  
Osman Sinen
Keyword(s):  
Maternal Separation ◽  
Neuropeptide S ◽  
Gastrointestinal Dysmotility ◽  
Neonatal Maternal Separation

Mast cells in the paraventricular nucleus participate in visceral hypersensitivity induced by neonatal maternal separation

2021 ◽  
Vol 402 ◽  
pp. 113113
Author(s):  
Ziyang Chen ◽  
Tiantian Zhou ◽  
Yongmei Zhang ◽  
Hongquan Dong ◽  
Wenjie Jin
Keyword(s):  
Mast Cells ◽  
Paraventricular Nucleus ◽  
Maternal Separation ◽  
Visceral Hypersensitivity ◽  
Neonatal Maternal Separation

Mesolimbic dopaminergic activity responding to acute stress is blunted in adolescent rats that experienced neonatal maternal separation

Neuroscience ◽  
2010 ◽  
Vol 171 (1) ◽  
pp. 144-152 ◽  
Author(s):  
J.W. Jahng ◽  
V. Ryu ◽  
S.B. Yoo ◽  
S.J. Noh ◽  
J.Y. Kim ◽  
...  
Keyword(s):  
Maternal Separation ◽  
Acute Stress ◽  
Dopaminergic Activity ◽  
Neonatal Maternal Separation ◽  
Adolescent Rats

Neonatal maternal separation and neuroendocrine programming of the respiratory control system in rats

2010 ◽  
Vol 84 (1) ◽  
pp. 26-38 ◽  
Author(s):  
Richard Kinkead ◽  
Roumiana Gulemetova
Keyword(s):  
Control System ◽  
Maternal Separation ◽  
Respiratory Control ◽  
Neonatal Maternal Separation

scholarly journals Long-Lasting Consequences of Neonatal Maternal Separation on Social Behaviors in Ovariectomized Female Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33028 ◽  
Author(s):  
Mumeko C. Tsuda ◽  
Sonoko Ogawa
Keyword(s):  
Maternal Separation ◽  
Social Behaviors ◽  
Female Mice ◽  
Neonatal Maternal Separation

Sustained hyperphagia in adolescent rats that experienced neonatal maternal separation

2008 ◽  
Vol 32 (9) ◽  
pp. 1355-1362 ◽  
Author(s):  
V Ryu ◽  
J-H Lee ◽  
S B Yoo ◽  
X F Gu ◽  
Y W Moon ◽  
...  
Keyword(s):  
Maternal Separation ◽  
Neonatal Maternal Separation ◽  
Adolescent Rats

Effect of neonatal maternal separation on serum level of nesfatin-1 in rats

2015 ◽  
Vol 23 (13) ◽  
pp. 2104
Author(s):  
Xiao-Ping Zhou
Keyword(s):  
Serum Level ◽  
Maternal Separation ◽  
Neonatal Maternal Separation

Neonatal maternal separation enhances phrenic responses to hypoxia and carotid sinus nerve stimulation in the adult anesthetized rat

2005 ◽  
Vol 99 (1) ◽  
pp. 189-196 ◽  
Author(s):  
Richard Kinkead ◽  
Roumiana Gulemetova ◽  
Aida Bairam
Keyword(s):  
Nerve Stimulation ◽  
Maternal Separation ◽  
Carotid Sinus ◽  
Ventilatory Response ◽  
Male Rats ◽  
Hypoxic Ventilatory Response ◽  
Carotid Sinus Nerve ◽  
Neonatal Maternal Separation ◽  
Carotid Sinus Nerve Stimulation ◽  
Series Of Experiments

In awake animals, our laboratory recently showed that the hypoxic ventilatory response of adult male (but not female) rats previously subjected to neonatal maternal separation (NMS) is 25% greater than controls (Genest SE, Gulemetova R, Laforest S, Drolet G, and Kinkead R. J Physiol 554: 543–557, 2004). To begin mechanistic investigations of the effects of this neonatal stress on respiratory control development, we tested the hypothesis that, in male rats, NMS enhances central integration of carotid body chemoafferent signals. Experiments were performed on two groups of adult male rats. Pups subjected to NMS were placed in a temperature-controlled incubator 3 h/day from postnatal day 3 to postnatal day 12. Control pups were undisturbed. At adulthood (8–10 wk), rats were anesthetized (urethane; 1.6 g/kg), paralyzed, and ventilated with a hyperoxic gas mixture [inspired O2 fraction (FiO2) = 0.5], and phrenic nerve activity was recorded. The first series of experiments aimed to demonstrate that NMS-related enhancement of the inspiratory motor output (phrenic) response to hypoxia occurs in anesthetized animals also. In this series, rats were exposed to moderate, followed by severe, isocapnic hypoxia (FiO2 = 0.12 and 0.08, respectively, 5 min each). NMS enhanced both the frequency and amplitude components of the phrenic response to hypoxia relative to controls, thereby validating the use of this approach. In a second series of experiments, NMS increased the amplitude (but not the frequency) response to unilateral carotid sinus nerve stimulation (stimulation frequency range: 0.5–33 Hz). We conclude that enhancement of central integration of carotid body afferent signal contributes to the larger hypoxic ventilatory response observed in NMS rats.

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