Effects of advanced glycation end products on dental pulp calcification

Oral Diseases ◽  
2021 ◽  
Author(s):  
Keita Sugiyama ◽  
Jiro Miura ◽  
Masato Shimizu ◽  
Aoi Takashima ◽  
Yusuke Matsuda ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Dental Pulp ◽  
Advanced Glycation ◽  
Dental Pulp Calcification ◽  
Glycation End Products ◽  
End Products ◽  
Pulp Calcification

Advanced glycation end products increase expression of S100A8 and A9viaRAGE-MAPK in rat dental pulp cells

Oral Diseases ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 328-334 ◽  
Author(s):  
Y Nakajima ◽  
Y Inagaki ◽  
J Kido ◽  
T Nagata
Keyword(s):  
Advanced Glycation End Products ◽  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Pulp Cells

Effects of Prolyl Hydroxylase Inhibitor L-mimosine on Dental Pulp in the Presence of Advanced Glycation End Products

2015 ◽  
Vol 41 (11) ◽  
pp. 1852-1861 ◽  
Author(s):  
Heinz-Dieter Müller ◽  
Barbara Cvikl ◽  
Klara Janjić ◽  
Sylvia Nürnberger ◽  
Andreas Moritz ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Dental Pulp ◽  
Prolyl Hydroxylase ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Prolyl Hydroxylase Inhibitor

scholarly journals Overexpression of Receptor for Advanced Glycation End Products and High-Mobility Group Box 1 in Human Dental Pulp Inflammation

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Salunya Tancharoen ◽  
Tassanee Tengrungsun ◽  
Theeralaksna Suddhasthira ◽  
Kiyoshi Kikuchi ◽  
Nuttavun Vechvongvan ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Dental Pulp ◽  
High Mobility ◽  
High Mobility Group ◽  
Dependent Manner ◽  
Advanced Glycation ◽  
Pulp Inflammation ◽  
Glycation End Products ◽  
End Products ◽  
Hmgb1 Expression

High mobility group box 1 (HMGB1), a nonhistone DNA-binding protein, is released into the extracellular space and promotes inflammation. HMGB1 binds to related cell signaling transduction receptors, including receptor for advanced glycation end products (RAGE), which actively participate in vascular and inflammatory diseases. The aim of this study was to examine whether RAGE and HMGB1 are involved in the pathogenesis of pulpitis and investigate the effect of Prevotella intermedia (P. intermedia) lipopolysaccharide (LPS) on RAGE and HMGB1 expression in odontoblast-like cells (OLC-1). RAGE and HMGB1 expression levels in clinically inflamed dental pulp were higher than those in healthy dental pulp. Upregulated expression of RAGE was observed in odontoblasts, stromal pulp fibroblasts-like cells, and endothelial-like cell lining human pulpitis tissue. Strong cytoplasmic HMGB1 immunoreactivity was noted in odontoblasts, whereas nuclear HMGB1 immunoreactivity was seen in stromal pulp fibroblasts-like cells in human pulpitis tissue. LPS stimulated OLC-1 cells produced HMGB1 in a dose-dependent manner through RAGE. HMGB1 translocation towards the cytoplasm and secretion from OLC-1 in response to LPS was inhibited by TPCA-1, an inhibitor of NF-κB activation. These findings suggest that RAGE and HMGB1 play an important role in the pulpal immune response to oral bacterial infection.

Advanced Glycation End-products Enhance Calcification in Cultured Rat Dental Pulp Cells

2013 ◽  
Vol 39 (7) ◽  
pp. 873-878 ◽  
Author(s):  
Yukiko Nakajima ◽  
Yuji Inagaki ◽  
Yuka Hiroshima ◽  
Jun-ichi Kido ◽  
Toshihiko Nagata
Keyword(s):  
Advanced Glycation End Products ◽  
Dental Pulp ◽  
Dental Pulp Cells ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
Pulp Cells

Der Rezeptor für advanced glycation end products (RAGE) mediiert Inflammation und fördert Tumorentstehung durch Interaktion mit Apoptosesignalwegen

2008 ◽  
Vol 46 (09) ◽  
Author(s):  
M Brune ◽  
T Schilling ◽  
W Stremmel ◽  
PH Krammer ◽  
A Bierhaus ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Concentration time profiles of plasma pentosidine in healthy volunteers following a breakfast rich in advanced glycation end products

2009 ◽  
Vol 34 (03) ◽  
Author(s):  
G Faustmann ◽  
I Sundl ◽  
A Meinitzer ◽  
M Maritschnegg ◽  
B Tiran ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Time Profiles ◽  
Concentration Time ◽  
Glycation End Products ◽  
End Products
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