Teucrium polium: Potential Drug Source for Type 2 Diabetes Mellitus

The prevalence of type 2 diabetes mellitus is rising globally and this disease is proposed to be the next pandemic after COVID-19. Although the cause of type 2 diabetes mellitus is unknown, it is believed to involve a complex array of genetic defects that affect metabolic pathways which eventually lead to hyperglycaemia. This hyperglycaemia arises from an inability of the insulin-sensitive cells to sufficiently respond to the secreted insulin, which eventually results in the inadequate secretion of insulin from pancreatic β-cells. Several treatments, utilising a variety of mechanisms, are available for type 2 diabetes mellitus. However, more medications are needed to assist with the optimal management of the different stages of the disease in patients of varying ages with the diverse combinations of other medications co-administered. Throughout modern history, some lead constituents from ancient medicinal plants have been investigated extensively and helped in developing synthetic antidiabetic drugs, such as metformin. Teucrium polium L. (Tp) is a herb that has a folk reputation for its antidiabetic potential. Previous studies indicate that Tp extracts significantly decrease blood glucose levels r and induce insulin secretion from pancreatic β-cells in vitro. Nonetheless, the constituent/s responsible for this action have not yet been elucidated. The effects appear to be, at least in part, attributable to the presence of selected flavonoids (apigenin, quercetin, and rutin). This review aims to examine the reported glucose-lowering effect of the herb, with a keen focus on insulin secretion, specifically related to type 2 diabetes mellitus. An analysis of the contribution of the key constituent flavonoids of Tp extracts will also be discussed.

A study on the nutritional characteristics of some plants and their effects on ruminal microbial fermentation and protozoa population

We designed this project to determine the nutritional potential and ruminal microbial fermentation properties of eight rangeland plants (Dracocephalum moldavica L., Melissa officinalis L., Ruta graveolens L., Perovskia abrotanoides Kar., Cichorium intybus L., Borago officinalis L., Peganum harmala L., and Teucrium polium L.) collected from the semi-arid region of Iran at two consecutive years (2019 and 2020) for ruminant diets. Medicago sativa as a common forage was also considered as control. We determined the chemical-mineral composition, buffering capacity, in vitro gas yield, ruminal fermentation, and protozoa population in a culture medium with the standard laboratory methods. A significant difference in chemical-mineral compounds was observed among the studied plants (p < 0.05). A lower crude protein range (6.28% for Cichorium intybus L. to 18.4% for Melissa officinalis L.) was observed rather than Medicago sativa (20.3%). The amount of calcium was highest in Peganum harmala L. (23.5–24.2 g/kg DM) and lowest in Ruta graveolens L. (1.15–1.25 g/kg DM). Dracocephalum moldavica L. exhibited the highest acid–base buffering capacity (235–242 mEq×10−3) among other plants. The highest decrease in total protozoa and other protozoan populations was observed when Perovskia abrotanoides Kar. was added to the culture medium. Teucrium Polium L. had the greatest potential gas yield and its total volatile fatty acid was comparable with Medicago sativa. It seems that eight plants are nutritionally suitable for partial replacement of the conventional plants such as Medicago sativa in diets of small ruminants, however dietary supplementation of Peganum harmala L. due to its alkaloids content should be done with caution.

Topical Administration of Teucrium polium on Diabetic Foot Ulcers Accelerates Healing: A Placebo-Controlled Randomized Clinical Study

Diabetic foot ulcer is one of the most devastating complications of uncontrolled diabetes. Although there have been advances in the management of diabetic foot ulcers, still diabetic foot ulcers are a major cause of many amputations in diabetic patients. Teucrium polium ( T. polium) is widely used by folk medicine practitioners in Iran for the treatment of diabetic ulcers. The present study was designed to evaluate the safety and efficacy of topical T. polium ointment besides the standard treatment in diabetic foot ulcers. A total of 70 diabetic patients with foot ulcers grade 1 or 2 according to Wagner's scale were enrolled in this study. Patients were randomly divided into two groups. Patients in both groups received standard treatment for diabetic foot ulcers. In addition, group 1 received topical T. polium ointment, and group 2 received topical placebo ointment for 4 weeks. The T. polium and placebo ointments were rubbed twice daily two hours before the conventional dressing. The ulcer size, healing time, and laboratory tests were measured in both groups at baseline and end of the study after 4 weeks. Twenty-nine patients remained in the T. polium group and 26 in the placebo group until the end of the study. The mean surface area of ulcers was 3.52 ± 1.47 and 3.21 ± 1.67 cm2 in T. polium group and placebo group respectively at baseline which decrease to .717 ± .19 and 1.63 ± .72 cm2 respectively at the endpoint. The mean ulcer surface area was significantly lower in T. polium compared with the placebo group ( p < .0001) at end of the study. Also, the number of patients that completely recovered in the T. polium group was significantly higher than the placebo group ( p < .001) at the end of the study. The addition of topical T. polium ointment to standard treatment significantly improves the healing time of diabetic non-infected foot ulcers.