Intestinal lymphoid nodular hyperplasia in children: The relationship to food allergy

2015 ◽  
Vol 26 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Sandra Lucarelli ◽  
Ginevra Lastrucci ◽  
Giovanni Di Nardo ◽  
Ylenia D'Alfonso ◽  
Marina Aloi ◽  
...  



The Lancet ◽  
1998 ◽  
Vol 351 (9103) ◽  
pp. 637-641 ◽  
Author(s):  
AJ Wakefield ◽  
SH Murch ◽  
A Anthony ◽  
J Linnell ◽  
DM Casson ◽  
...  


2018 ◽  
Vol 113 (1) ◽  
pp. 11
Author(s):  
Rui Gaspar ◽  
Eduardo Rodrigues-Pinto ◽  
Guilherme Macedo


2020 ◽  
Vol 16 (2) ◽  
pp. 115-122
Author(s):  
Olga Domínguez ◽  
Ana María Plaza ◽  
Montserrat Alvaro

Consistent evidence has been found on the relationship between food allergy (FA) and atopic dermatitis (AD) in some children. Food sensitization can be often found in these patients. Allergy should be confirmed, though, with a food challenge test (FC) before advising a restrictive diet which could be harmful for the patient. Younger children with AD frequently show sensitization to egg, milk or peanut, while older ones and adults are more often sensitized to environmental allergens such as house dust mites, moulds, animal dander or pollens. It is well known that a barrier disturbance plays a main role in the development of sensitization and allergy. Therefore, due to the early appearance of AD, preventive newborn skincare with emollients and early introduction of food appear to be very important to determine food tolerance.



2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Maria Suprun ◽  
Robert Getts ◽  
Rohit Raghunathan ◽  
Galina Grishina ◽  
Marc Witmer ◽  
...  

AbstractIdentification of allergenic IgE epitopes is instrumental for the development of novel diagnostic and prognostic methods in food allergy. In this work, we present the quantification and validation of a Bead-Based Epitope Assay (BBEA) that through multiplexing of epitopes and multiple sample processing enables completion of large experiments in a short period of time, using minimal quantities of patients’ blood. Peptides that are uniquely coupled to beads are incubated with serum or plasma samples, and after a secondary fluorophore-labeled antibody is added, the level of fluorescence is quantified with a Luminex reader. The signal is then normalized and converted to epitope-specific antibody binding values. We show that the effect of technical artifacts, i.e. well position or reading order, is minimal; and batch effects - different individual microplate runs - can be easily estimated and eliminated from the data. Epitope-specific antibody binding quantified with BBEA is highly reliable, reproducible and has greater sensitivity of epitope detection compared to peptide microarrays. IgE directed at allergenic epitopes is a sensitive biomarker of food allergy and can be used to predict allergy severity and phenotypes; and quantification of the relationship between epitope-specific IgE and IgG4 can further improve our understanding of the immune mechanisms behind allergic sensitization.



2015 ◽  
Vol 135 (2) ◽  
pp. AB43
Author(s):  
Barry J. Pelz ◽  
Joshua B. Wechsler ◽  
Rebecca Krier-Burris ◽  
Barry Wershil ◽  
Amir F. Kagalwalla ◽  
...  




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