A 250‐kDa glycoprotein of Naegleria fowleri induces protection and modifies the expression of α4β1 and LFA‐1 on T and B lymphocytes in mouse meningitis model

2021 ◽  
Author(s):  
Diego A. Castillo‐Ramírez ◽  
María Maricela Carrasco‐Yépez ◽  
Itzel Berenice Rodríguez‐Mera ◽  
Aldo Arturo Reséndiz‐Albor ◽  
Érica Rosales‐Cruz ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
T And B Lymphocytes ◽  
Naegleria Fowleri ◽  
Nægleria Fowleri

The protective effects of monoclonal antibodies in mice from Naegleria fowleri infection

1992 ◽  
Vol 30 (2) ◽  
pp. 113 ◽  
Author(s):  
E Y Soh ◽  
H J Shin ◽  
K Im
Keyword(s):  
Monoclonal Antibodies ◽  
Protective Effects ◽  
Naegleria Fowleri ◽  
Nægleria Fowleri

Relationship among T- and B-lymphocytes of the peripheral blood and thyroid tissue in patients with Graves' disease

2019 ◽  
Author(s):  
Margarita A Dudina ◽  
Andrey A Savchenko ◽  
Sergey A Dogadin ◽  
Alexandr G Borisov ◽  
Igor V Kudryavcev ◽  
...  
Keyword(s):  
B Lymphocytes ◽  
Peripheral Blood ◽  
Thyroid Tissue ◽  
T And B Lymphocytes ◽  
Graves Disease

Efficacy of a combined system of copper and silver and free chlorine for inactivation of Naegleria fowleri amoebas in water

1995 ◽  
Vol 31 (5-6) ◽  
pp. 119-122 ◽  
Author(s):  
J. M. Cassells ◽  
M. T. Yahya ◽  
C. P. Gerba ◽  
J. B. Rose
Keyword(s):  
Synergistic Effect ◽  
Exposure Time ◽  
Silver Ions ◽  
Free Chlorine ◽  
Log10 Reduction ◽  
Naegleria Fowleri ◽  
Combined System ◽  
Water Ph ◽  
Nægleria Fowleri ◽  
Time Required

Electrolytically generated copper and silver ions (400:40 and 800:80 μg/l) were evaluated, separately and combined with 1.0 mg/l free chlorine, for their efficacy in reducing the viable numbers of Naegleria fowleri amoebas in water (pH 7.3 and 23-25°C). Inactivation rates (k = log10 reduction/min) and T99 values (exposure time required to achieve a 99% or a 2 log10 reduction) of the disinfectants were determined. Copper and silver alone, at ratio of 400:40 to 800:80 μg/l caused no significant inactivation of N. fowleri even after 72 hours of exposure (k = 0.00017 and 0.00013, respectively). Addition of 1.0 mg/l free chlorine to water which contained 400:40 or 800:80 μg/l copper and silver resulted in enhanced inactivation rates (k = 0.458 and 0.515, respectively) compared to either chlorine alone (k = 0.33) or the metals alone. Water containing 800:80 μg/l copper and silver with 1.0 mg/l chlorine showed a T99 value of 3.9 minutes, while chlorine alone showed a T99 of 6.1 minutes. Enhanced inactivation of N. fowleri by a combined system of free chlorine and copper and silver may be attributed to the different mechanism that each disinfectant utilizes in inactivating the amoebas, and may suggest a synergistic effect.

scholarly journals Transplantable progenitors of natural killer cells are distinct from those of T and B lymphocytes.

1986 ◽  
Vol 83 (10) ◽  
pp. 3427-3431 ◽  
Author(s):  
J. Hackett ◽  
G. C. Bosma ◽  
M. J. Bosma ◽  
M. Bennett ◽  
V. Kumar
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
B Lymphocytes ◽  
T And B Lymphocytes ◽  
Killer Cells

scholarly journals A Novel Cysteine Protease Inhibitor of Naegleria fowleri That Is Specifically Expressed during Encystation and at Mature Cysts

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 388
Author(s):  
Hương Giang Lê ◽  
A-Jeong Ham ◽  
Jung-Mi Kang ◽  
Tuấn Cường Võ ◽  
Haung Naw ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Cysteine Protease ◽  
Expression Profiles ◽  
Critical Role ◽  
Cyst Formation ◽  
Cysteine Proteases ◽  
Cysteine Protease Inhibitor ◽  
Naegleria Fowleri ◽  
Nægleria Fowleri ◽  
Cystatin Family

Naegleria fowleri is a free-living amoeba that is ubiquitous in diverse natural environments. It causes a fatal brain infection in humans known as primary amoebic meningoencephalitis. Despite the medical importance of the parasitic disease, there is a great lack of knowledge about the biology and pathogenicity of N. fowleri. In this study, we identified and characterized a novel cysteine protease inhibitor of N. fowleri (NfCPI). NfCPI is a typical cysteine protease inhibitor belonging to the cystatin family with a Gln-Val-Val-Ala-Gly (QVVAG) motif, a characteristic motif conserved in the cystatin family of proteins. Bacterially expressed recombinant NfCPI has a dimeric structure and exhibits inhibitory activity against several cysteine proteases including cathespin Bs of N. fowleri at a broad range of pH values. Expression profiles of nfcpi revealed that the gene was highly expressed during encystation and cyst of the amoeba. Western blot and immunofluorescence assays also support its high level of expression in cysts. These findings collectively suggest that NfCPI may play a critical role in encystation or cyst formation of N. fowleri by regulating cysteine proteases that may mediate encystation or mature cyst formation of the amoeba. More comprehensive studies to investigate the roles of NfCPI in encystation and its target proteases are necessary to elucidate the regulatory mechanism and the biological significance of NfCPI.

Transmission of Naegleria fowleri between Mice

1983 ◽  
Vol 69 (1) ◽  
pp. 249 ◽  
Author(s):  
R. G. May ◽  
D. T. John
Keyword(s):  
Naegleria Fowleri ◽  
Nægleria Fowleri

Monoclonal antibodies that distinguish bovine T and B lymphocytes

1985 ◽  
Vol 9 (1) ◽  
pp. 87-102 ◽  
Author(s):  
Harris A. Lewin ◽  
William C. Davis ◽  
Domenico Bernoco
Keyword(s):  
Monoclonal Antibodies ◽  
B Lymphocytes ◽  
T And B Lymphocytes

Development of antigenic heterogeneity in the splenic meshwork of severe combined immunodeficient (SCID) mice after reconstitution with T and B lymphocytes

1993 ◽  
Vol 272 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Kikuyoshi Yoshida ◽  
Noboru Matsuura ◽  
Nobuaki Tamahashi ◽  
Tohru Takahashi
Keyword(s):  
B Lymphocytes ◽  
Scid Mice ◽  
T And B Lymphocytes ◽  
Antigenic Heterogeneity

Separation of T and B lymphocytes by preparative cell electrophoresis

1972 ◽  
Vol 2 (5) ◽  
pp. 405-410 ◽  
Author(s):  
S. Nordling ◽  
L. C. Andersson ◽  
P. Häyry
Keyword(s):  
B Lymphocytes ◽  
T And B Lymphocytes ◽  
Cell Electrophoresis
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