scholarly journals Common Adverse Effects and Complications of Long-Term Opioid Therapy

Pain Medicine ◽  
2015 ◽  
Vol 16 (suppl 1) ◽  
pp. S1-S2 ◽  
Author(s):  
Perry Fine ◽  
Martin D. Cheatle
Keyword(s):  
Adverse Effects ◽  
Opioid Therapy

scholarly journals A Review of Potential Adverse Effects of Long-Term Opioid Therapy

2012 ◽  
Author(s):  
AnGee Baldini ◽  
Michael Von Korff ◽  
Elizabeth H. B. Lin
Keyword(s):  
Adverse Effects ◽  
Opioid Therapy

scholarly journals Effectiveness of Long-Term Opioid Therapy for Chronic Non-Cancer Pain

2011 ◽  
Vol 3;14 (2;3) ◽  
pp. E133-E156 ◽  
Author(s):  
Laxmaiah Manchikanti
Keyword(s):  
Pain Relief ◽  
Adverse Effects ◽  
Cancer Pain ◽  
Functional Status ◽  
Outcome Measures ◽  
Opioid Therapy ◽  
Review Of The Literature ◽  
Chronic Opioid Therapy ◽  
Comprehensive Review

Background: Opioids have been utilized for thousands of years to treat pain and their use continues to escalate. It is estimated that 90% of the patients who present to pain centers and receive treatment in such facilities are on opioids. However, in contrast to increasing opioid use and the lack of evidence supporting long-term effectiveness in chronic non-cancer pain, is the escalating misuse of prescription opioids, including abuse and diversion. There is also uncertainty about the incidence and clinical salience of multiple, poorly characterized adverse drug events, including endocrine dysfunction, immunosuppression, infectious disease, opioidinduced hyperalgesia, overdoses, deaths, and psychosocial and economic implications. Study Design: A comprehensive review of the literature. Objective: The objective of this comprehensive review is to evaluate the clinical effectiveness and safety of chronic opioid therapy in chronic non-cancer pain. Methods: A comprehensive review of the literature relating to chronic opioid therapy in chronic non-cancer pain. The literature was collected from various electronic and other sources. The literature that was evaluated included randomized trials, observational studies, case reports, systematic reviews, and guidelines. Outcome Measures: Pain relief was the primary outcome measure. The secondary outcome measures were functional improvement and adverse effects. Short-term effectiveness was considered to be less than 6 months; long-term effectiveness was considered to be at least one year. Results: Given the complexity and widespread nature of opioid therapy, there is a paucity of qualitative and/or quantitative literature. The available evidence is weak for pain relief combined with improvement in functional status. Only one drug, tramadol, is effective for pain relief and improvement of functional status. Limitations: This is a narrative review without application of methodologic quality assessment criteria. Even so, a paucity of literature exists concerning both controlled and observational literature for multiple drugs and multiple conditions of chronic non-cancer pain. Conclusions: This comprehensive review illustrates the lack of literature on long-term opioid therapy; thus, opioid therapy should be provided with great restraint and caution, based on the weak evidence available. Key words: Chronic non-cancer pain, opioids, opioid effectiveness, adverse effects, morphine, hydrocodone, hydromorphone, fentanyl, tramadol, methadone, oxycodone

Oil pollution and fisheries

1982 ◽  
Vol 297 (1087) ◽  
pp. 401-411 ◽  
Keyword(s):  
Water Quality ◽  
Adverse Effects ◽  
Oil Pollution ◽  
Coastal Areas ◽  
Short Term ◽  
Fish Stocks ◽  
Local Impacts ◽  
Reduced Water ◽  
Long Term Adverse Effects

The term ‘pollution’ is taken in its broadest sense and effects are recognized to be due to interference, tainting and toxicity. Each of these types of impact is discussed and assessed. It is concluded that no long-term adverse effects on fish stocks can be attributed to oil but that local impacts can be extremely damaging in the short term and that produce from specific localities can be tainted and unmarketable for long periods. In some coastal areas oil can be one among several contributors to reduced water quality, and the implications of this are discussed.

Prevalence of long-term opioid therapy in spine center outpatients the spinal pain opioid cohort (SPOC)

2021 ◽  
Author(s):  
Claus Manniche ◽  
Lonny Stokholm ◽  
Sophie L. Ravn ◽  
Tonny A. Andersen ◽  
Lars Brandt ◽  
...  
Keyword(s):  
Spinal Pain ◽  
Opioid Therapy

scholarly journals Racial disparities in discontinuation of long-term opioid therapy following illicit drug use among black and white patients

2018 ◽  
Vol 192 ◽  
pp. 371-376 ◽  
Author(s):  
Julie R. Gaither ◽  
Kirsha Gordon ◽  
Stephen Crystal ◽  
E. Jennifer Edelman ◽  
Robert D. Kerns ◽  
...  
Keyword(s):  
Drug Use ◽  
Racial Disparities ◽  
Illicit Drug ◽  
Illicit Drug Use ◽  
Opioid Therapy ◽  
Black And White ◽  
White Patients

scholarly journals The Acute and Long-Term Adverse Effects of Shock Wave Lithotripsy

2008 ◽  
Vol 28 (2) ◽  
pp. 200-213 ◽  
Author(s):  
James A. McAteer ◽  
Andrew P. Evan
Keyword(s):  
Shock Wave ◽  
Adverse Effects ◽  
Shock Wave Lithotripsy ◽  
Long Term Adverse Effects

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

Toxicology ◽  
2014 ◽  
Vol 325 ◽  
pp. 133-143 ◽  
Author(s):  
Alice Marmugi ◽  
Frederic Lasserre ◽  
Diane Beuzelin ◽  
Simon Ducheix ◽  
Laurence Huc ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Bisphenol A

scholarly journals Variations in Long‐Term Opioid Therapy Definitions: A Systematic Review of Observational Studies Using Routinely Collected Data (2000–2019)

2021 ◽  
Author(s):  
Juliana Oliveira Costa ◽  
Claudia Bruno ◽  
Navya Baranwal ◽  
Natasa Gisev ◽  
Timothy Dobbins ◽  
...  
Keyword(s):  
Systematic Review ◽  
Observational Studies ◽  
Opioid Therapy ◽  
Routinely Collected Data

Clinician Identification of Appropriate Long-term Opioid Therapy Candidacy—Reply

2012 ◽  
Vol 172 (14) ◽  
pp. 1110 ◽  
Author(s):  
Mark Sullivan ◽  
Jane Ballantyne
Keyword(s):  
Opioid Therapy
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