The effectiveness of electroconvulsive therapy for psychiatric symptoms and cognitive fluctuations similar to dementia with Lewy bodies: a case report

Dementia with Lewy bodies (DLB) is the second most common neuropathologically diagnosed cause of degenerating dementia after Alzheimer's disease. We report the first autopsy-confirmed case in sub-Saharan Africa in a Nigerian patient. The case presented highlights the varied clinical presentation of DLB, and is intended to raise awareness about another possible cause of dementia in Nigerian subjects.

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Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies: a case report

Psychogeriatrics ◽

10.1111/j.1479-8301.2012.00411.x ◽

2012 ◽

Vol 12 (4) ◽

pp. 255-258 ◽

Cited By ~ 4

Author(s):

Asami OZAKI ◽

Masaki NISHIDA ◽

Keiko KOYAMA ◽

Kinya ISHIKAWA ◽

Toru NISHIKAWA

Keyword(s):

Case Report ◽

Dementia With Lewy Bodies ◽

Lewy Bodies ◽

Sleep Spindle

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Quetiapine-induced neuroleptic malignant syndrome in dementia with Lewy bodies: A case report

Progress in Neuro-Psychopharmacology and Biological Psychiatry ◽

10.1016/j.pnpbp.2006.04.001 ◽

2006 ◽

Vol 30 (6) ◽

pp. 1170-1172 ◽

Cited By ~ 24

Author(s):

Akiko Kobayashi ◽

Chiaki Kawanishi ◽

Takehiko Matsumura ◽

Daiji Kato ◽

Ryoko Furukawa ◽

...

Keyword(s):

Case Report ◽

Neuroleptic Malignant Syndrome ◽

Dementia With Lewy Bodies ◽

Lewy Bodies

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Assessing Nigrostriatal Dopaminergic Pathways via 123I-FP-CIT SPECT in Dementia With Lewy Bodies in a Psychiatric Patient Cohort

Frontiers in Aging Neuroscience ◽

10.3389/fnagi.2021.672956 ◽

2021 ◽

Vol 13 ◽

Author(s):

Niels Hansen ◽

Claudia Lange ◽

Charles Timäus ◽

Jens Wiltfang ◽

Caroline Bouter

Keyword(s):

Dementia With Lewy Bodies ◽

Psychiatric Symptoms ◽

Single Photon ◽

Medical Center ◽

Psychiatric Patients ◽

Photon Emission ◽

Lewy Bodies ◽

Emission Computed Tomography ◽

Psychiatric Symptomatology ◽

Memory Clinics

Background(123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)-N-(3-fluoropropyl) nortro- pane single photon emission computed tomography (123I-FP-CIT SPECT) was validated to distinguish Alzheimer’s dementia from dementia with Lewy Bodies (DLB) by European medical agencies. Little evidence exists that validates 123 I-FP-CIT SPECT as a supplementary method to diagnose probable DLB in a psychiatric cohort of patients with psychiatric symptomatology and suspected DLB. We aim to elucidate differences in the clinical phenotype of DLB between those patients with and those without a positive 123 I-FP-CIT SPECT indicating a nigrostriatal deficit.MethodsTo investigate this, we included 67 patients from the Department of Psychiatry and Psychotherapy at University Medical Center Göttingen (UMG) in our study who had undergone 123I-FP-CIT SPECT in the Department of Nuclear Medicine (UMG) by evaluating their patient files.Results55% with a positive-123I-FP-CIT SPECT and probable DLB after the 123I-FP-CIT SPECT exhibited psychiatric features. The number of probable DLB patients in those exhibiting psychiatric symptoms was higher post-123I-FP-CIT SPECT than pre-123I-FP-CIT SPECT assessed cross-sectionally over a 6-year period (p < 0.05). In addition, prodromal DLB and prodromal DLB patients with a psychiatric-phenotype yielded higher numbers post-123I-FP-CIT SPECT than pre-123I-FP-CIT SPECT (p < 0.05). Furthermore, we discovered no phenotypical differences between those DLB patients with a positive and those with a negative 123I-FP-CIT SPECT. 123I-FP-CIT SPECT-positive DLB patients in our psychiatric cohort revealed a psychiatric onset more often (52%); DLB was less often characterized by an MCI onset (26%) (p < 0.005).ConclusionsOur findings support 123I-FP-CIT SPECT as an adjuvant tool for improving the diagnosis of probable DLB and prodromal DLB in a cohort of psychiatric patients with often concomitant psychiatric symptomatology. The psychiatric-onset is more frequent than an MCI-onset in DLB patients presenting nigrostriatal dysfunction, giving us an indication of the relevance of deep clinical phenotyping in memory clinics that includes the assessment of psychopathology.

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