Induced pluripotent stem cells reduce neutrophil chemotaxis via activating GRK2 in endotoxin-induced acute lung injury

Respirology ◽  
2017 ◽  
Vol 22 (6) ◽  
pp. 1156-1164 ◽  
Author(s):  
Vincent Yi-Fong Su ◽  
Shih-Hwa Chiou ◽  
Chi-Shiuan Lin ◽  
Wei-Chih Chen ◽  
Wen-Kuang Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Neutrophil Chemotaxis ◽  
Induced Pluripotent

scholarly journals Induced Pluripotent Stem Cells Attenuate Acute Lung Injury Induced by Ischemia Reperfusion via Suppressing the High Mobility Group Box-1

Dose-Response ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 155932582096934
Author(s):  
Yijun Li ◽  
Shun Wang ◽  
Jinbo Liu ◽  
Xingyu Li ◽  
Meng Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Lung Injury ◽  
Endothelial Cell ◽  
Lung Injury ◽  
Induced Pluripotent Stem Cells ◽  
Inflammatory Cytokines ◽  
Pluripotent Stem Cells ◽  
Ischemia Reperfusion ◽  
High Mobility ◽  
Induced Pluripotent

Pulmonary endothelial cell injury is a hallmark of acute lung injury. High-mobility group box 1 (HMGB1) can modulate the inflammatory response via endothelial cell activation and release of inflammatory molecules. Thus, we tested whether induced pluripotent stem cells (iPSCs) can alleviate ischemia/reperfusion (I/R) induced lung injury, and, if so, whether HMGB1 mediates the effect in a male C57BL/6 mouse model. Intravenously injected iPSCs into mice 2 h after I/R showed a significant attenuation of lung injury (assessed by lung mechanics, edema, and histology) 24 h after reperfusion (compared with controls), along with decreases in HMGB1, phosphorylated nuclear factor-κB, inflammatory cytokines [interleukin (IL)1β, IL6 and tumor necrosis factor-α], and the activation of endothelial cells. Furthermore, these effects of iPSCs can be mimicked by blocking HMGB1 with an inhibitor in vivo and in vitro. We conclude that iPSCs can be a potential therapy for I/R-induced lung injury. These cells may exert therapeutic effects through blocking HMGB1 and inflammatory cytokines.

scholarly journals IV Delivery of Induced Pluripotent Stem Cells Attenuates Endotoxin-Induced Acute Lung Injury in Mice

CHEST Journal ◽  
2011 ◽  
Vol 140 (5) ◽  
pp. 1243-1253 ◽  
Author(s):  
Kuang-Yao Yang ◽  
Hsin-Chin Shih ◽  
Chorng-Kuang How ◽  
Cheng-Yu Chen ◽  
Han-Shui Hsu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Induced Pluripotent

Induced pluripotent stem cells alleviate lung injury from mesenteric ischemia-reperfusion

2015 ◽  
Vol 79 (4) ◽  
pp. 592-601 ◽  
Author(s):  
Chorng-Kuang How ◽  
Sen-Kuang Hou ◽  
Luen-Kui Chen ◽  
Cheng-Ming Yang ◽  
Hsien-Hao Huang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Lung Injury ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Mesenteric Ischemia ◽  
Ischemia Reperfusion ◽  
Induced Pluripotent

Directed differentiation of mouse-induced pluripotent stem cells generates dopaminergic nerve

2010 ◽  
Vol 34 (8) ◽  
pp. S36-S36
Author(s):  
Ping Duan ◽  
Xuelin Ren ◽  
Wenhai Yan ◽  
Xuefei Han ◽  
Xu Yan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Induced Pluripotent Stem Cells ◽  
Pluripotent Stem Cells ◽  
Directed Differentiation ◽  
Induced Pluripotent
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