scholarly journals Induced Pluripotent Stem Cells Regulate Triggering Receptor Expressed on Myeloid Cell-1 Expression and the p38 Mitogen-Activated Protein Kinase Pathway in Endotoxin-Induced Acute Lung Injury

Stem Cells ◽  
2019 ◽  
Vol 37 (5) ◽  
pp. 631-639 ◽  
Author(s):  
Vincent Yi-Fong Su ◽  
Kuang-Yao Yang ◽  
Shih-Hwa Chiou ◽  
Nien-Jung Chen ◽  
Min-Hsiang Mo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Lung Injury ◽  
Protein Kinase ◽  
Lung Injury ◽  
Pluripotent Stem Cells ◽  
Myeloid Cell ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Induced Pluripotent ◽  
Kinase Pathway

scholarly journals Induced Pluripotent Stem Cells Attenuate Acute Lung Injury Induced by Ischemia Reperfusion via Suppressing the High Mobility Group Box-1

Dose-Response ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 155932582096934
Author(s):  
Yijun Li ◽  
Shun Wang ◽  
Jinbo Liu ◽  
Xingyu Li ◽  
Meng Lu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Lung Injury ◽  
Endothelial Cell ◽  
Lung Injury ◽  
Induced Pluripotent Stem Cells ◽  
Inflammatory Cytokines ◽  
Pluripotent Stem Cells ◽  
Ischemia Reperfusion ◽  
High Mobility ◽  
Induced Pluripotent

Pulmonary endothelial cell injury is a hallmark of acute lung injury. High-mobility group box 1 (HMGB1) can modulate the inflammatory response via endothelial cell activation and release of inflammatory molecules. Thus, we tested whether induced pluripotent stem cells (iPSCs) can alleviate ischemia/reperfusion (I/R) induced lung injury, and, if so, whether HMGB1 mediates the effect in a male C57BL/6 mouse model. Intravenously injected iPSCs into mice 2 h after I/R showed a significant attenuation of lung injury (assessed by lung mechanics, edema, and histology) 24 h after reperfusion (compared with controls), along with decreases in HMGB1, phosphorylated nuclear factor-κB, inflammatory cytokines [interleukin (IL)1β, IL6 and tumor necrosis factor-α], and the activation of endothelial cells. Furthermore, these effects of iPSCs can be mimicked by blocking HMGB1 with an inhibitor in vivo and in vitro. We conclude that iPSCs can be a potential therapy for I/R-induced lung injury. These cells may exert therapeutic effects through blocking HMGB1 and inflammatory cytokines.

scholarly journals MKK3 Mitogen-Activated Protein Kinase Pathway Mediates Carbon Monoxide-Induced Protection Against Oxidant-Induced Lung Injury

2003 ◽  
Vol 163 (6) ◽  
pp. 2555-2563 ◽  
Author(s):  
Leo E. Otterbein ◽  
Sherrie L. Otterbein ◽  
Emeka Ifedigbo ◽  
Fang Liu ◽  
Danielle E. Morse ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Protein Kinase ◽  
Lung Injury ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Kinase Pathway

scholarly journals Mitogen-activated Protein Kinase Kinase Kinase 1 Protects against Nickel-induced Acute Lung Injury

2008 ◽  
Vol 104 (2) ◽  
pp. 405-411 ◽  
Author(s):  
Maureen Mongan ◽  
Zongqing Tan ◽  
Liang Chen ◽  
Zhimin Peng ◽  
Maggie Dietsch ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Protein Kinase ◽  
Lung Injury ◽  
Mitogen Activated Protein Kinase ◽  
Mitogen Activated Protein ◽  
Protein Kinase Kinase
Sign in / Sign up

Export Citation Format

Share Document