P1‐76: Rare endobronchial squamous papilloma causing recurrent pneumonia

Abstract Background Community-acquired pneumonia (CAP) in infancy (i.e., among children aged < 2 years) may have long-term consequences for the rapidly developing lung. We examined the impact of pneumonia in infancy on subsequent respiratory health. Methods A retrospective matched-cohort design and data from Optum’s de-identified Integrated Claims-Clinical dataset (2009-2018) were employed. Study population comprised children who were hospitalized for CAP before age 2 years (“CAP patients”) as well as matched comparators without evidence of pneumonia before age 2 years (“comparison patients”). CAP patients and comparison patients were matched (fixed 1:5 ratio, without replacement) using estimated propensity scores and a nearest-neighbor approach; those with evidence of selected medical conditions (e.g., extreme prematurity, congenital diseases, respiratory diseases) before age 2 years were excluded. Study outcomes included recurrent pneumonia and a composite of asthma, recurrent wheezing, and hyperactive airway disease. Rates of study outcomes from age 2 to 5 years were estimated for all CAP and comparison patients as well as subgroups of CAP patients (and corresponding comparison patients) stratified by etiology (bacterial, viral, unspecified). Results Study population totaled 1,343 CAP patients and 6,715 comparison patients. CAP patients and comparison patients were well-balanced on their baseline characteristics and mean duration of follow-up was 757 and 729 days, respectively. Rates of chronic respiratory disorders from age 2 to 5 years were significantly higher among CAP patients versus comparison patients. Analyses of subgroups stratified by etiology demonstrated higher rates of study outcomes among CAP patients across all strata. Rates of recurrent pneumonia and a composite of asthma, recurrent wheezing, and hyperactive airway disease from age 2 to 5 years among CAP patients and matched comparison patients Conclusion Infant CAP foreshadows an increase in subsequent risk of chronic respiratory disorders. Further studies are needed to determine whether this elevated risk is due to infant pneumonia or whether infant pneumonia is a marker of at-risk children. Disclosures Stephen I. Pelton, MD, Merck vaccine (Consultant, Grant/Research Support)Pfizer (Consultant, Grant/Research Support)Sanofi Pasteur (Consultant, Other Financial or Material Support, DSMB)Seqirus Vaccine Ltd. (Consultant) Rotem Lapidot, MD, MSCI, Pfizer (Consultant) Matthew Wasserman, MSc., Pfizer Inc. (Employee) Melody Shaff, BA, Pfizer, Inc. (Consultant, Grant/Research Support, Scientific Research Study Investigator, Research Grant or Support) Ahuva Hanau, BS, Pfizer, Inc. (Consultant, Grant/Research Support, Scientific Research Study Investigator, Research Grant or Support) Alexander Lonshteyn, PhD, Pfizer, Inc. (Consultant, Grant/Research Support, Scientific Research Study Investigator, Research Grant or Support) Derek Weycker, PhD, Pfizer Inc. (Consultant, Grant/Research Support, Scientific Research Study Investigator, Research Grant or Support)

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Acquired tracheo-oesophageal fistula in a child with unrecognised tracheal foreign body

BMJ Case Reports ◽

10.1136/bcr-2020-240947 ◽

2021 ◽

Vol 14 (4) ◽

pp. e240947

Author(s):

Kanokpan Ruangnapa ◽

Wanaporn Anuntaseree ◽

Kantara Saelim ◽

Pharsai Prasertsan

Keyword(s):

Foreign Body ◽

Young Children ◽

Respiratory Symptoms ◽

Growth Failure ◽

Late Diagnosis ◽

Feeding Intolerance ◽

Recurrent Pneumonia ◽

High Index Of Suspicion ◽

Careful Investigation

We report the case of a 6-month-old girl who presented with recurrent pneumonia and growth failure. After full examination, she was diagnosed with long-standing, unrecognised tracheal foreign body, which was then successfully removed. However, her chronic respiratory symptoms did not improve, and she also had feeding intolerance. The persistence of symptoms indicated a second bronchoscopy and finally an acquired tracheo-oesophageal fistula was diagnosed. This case emphasises the challenges in diagnosis of an inhaled foreign body in young children. Late diagnosis of this condition can cause significant morbidities. A high index of suspicion and careful investigation are very important to prevent long-term complications.

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Acquired pure red cell aplasia and T cell large granular lymphocytic leukaemia in patients with autoimmune polyglandular syndrome type 1

BMC Medical Genomics ◽

10.1186/s12920-020-00866-y ◽

2021 ◽

Vol 14 (1) ◽

Author(s):

Jing Ruan ◽

Xuan Wang ◽

Xianyong Jiang ◽

Miao Chen

Keyword(s):

Lymphocytic Leukaemia ◽

Pure Red Cell Aplasia ◽

Chronic Diarrhoea ◽

Syndrome Type ◽

Red Cell ◽

Recurrent Pneumonia ◽

Red Cell Aplasia ◽

Autoimmune Polyendocrine Syndrome ◽

Immunological Mechanisms

Abstract Background Pure red cell aplasia (PRCA) and large granular lymphocytic leukaemia (LGLL) are very rare complications of autoimmune polyendocrine syndrome type 1 (APS1). Here, we report a case of APS1 with PRCA and LGLL. Previous cases were reviewed, and possible mechanisms are discussed. Case presentation A 31-year-old female presented with anaemia and was diagnosed with PRCA in our centre. She also had hypoparathyroidism for 24 years, premature ovarian failure for 10 years, osteoporosis for 5 years, recurrent pneumonia with bronchiectasis for 4 years and chronic diarrhoea for 1 year. Boosted whole-exome analysis showed AIRE heterozygous mutations, confirming the diagnosis as APS1. LGLL was diagnosed during follow-up. The PRCA responded well to glucocorticoid. treatment Conclusion AIRE is causally related to the development of LGLL and consequent PRCA, which may be due to some immunological mechanisms.

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Recurrent Pneumonia in a Young Adult

Clinical Pulmonary Medicine ◽

10.1097/01.cpm.0000236693.25217.f3 ◽

2006 ◽

Vol 13 (5) ◽

pp. 311-314

Author(s):

Theodore J. Lee ◽

Jessica W. T. Leung ◽

Gautham P. Reddy ◽

Michael B. Gotway

Keyword(s):

Young Adult ◽

Recurrent Pneumonia

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Middle ear squamous papilloma: A report of four cases analyzed by HPV and EBV in situ hybridization

Oncology Letters ◽

10.3892/ol.2013.1675 ◽

2013 ◽

Vol 7 (1) ◽

pp. 41-46 ◽

Cited By ~ 1

Author(s):

HAN ZHOU ◽

ZHIBIN CHEN ◽

WEIMING ZHANG ◽

GUANGQIAN XING

Keyword(s):

In Situ Hybridization ◽

Middle Ear ◽

Squamous Papilloma

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Conjunctival inverted squamous papilloma: A case report with immunohistochemical analysis and review of the literature

Survey of Ophthalmology ◽

10.1016/j.survophthal.2014.10.004 ◽

2015 ◽

Vol 60 (3) ◽

pp. 263-268 ◽

Cited By ~ 5

Author(s):

Anna M. Stagner ◽

Frederick A. Jakobiec ◽

Anthony Chi ◽

Scott H. Bradshaw ◽

Silvino Diaz Mendoza

Keyword(s):

Case Report ◽

Immunohistochemical Analysis ◽

Review Of The Literature ◽

Squamous Papilloma

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Benign Focal Epilepsy of Childhood and Gastroesophagael Reflux

Canadian Journal of Gastroenterology ◽

10.1155/1994/725067 ◽

1994 ◽

Vol 8 (1) ◽

pp. 45-48

Author(s):

Anne G Sheehan ◽

Sherry Pelensky ◽

Colin Van Orman ◽

Steven R Martin

Keyword(s):

Gastroesophageal Reflux ◽

Sudden Infant Death Syndrome ◽

Infant Death ◽

Chronic Cough ◽

Focal Epilepsy ◽

Sudden Infant Death ◽

Acute Onset ◽

Sudden Infant ◽

Recurrent Pneumonia ◽

Essentially Normal

Gastroesophageal reflux has been associated with, and implicated in, a number of conditions, including respiratory disease (recurrent pneumonia, chronic cough, asthma), sudden infant death syndrome, dysphagia and central nervous disorders. An eight-year-old girl presented with an acute history that suggested gastroesophageal reflux. An esophageal motility study was abnormal and 24 h pH study demonstrated gastroesophageal reflux. Before the manometric study, a seizure was observed and subsequent neurological evaluation confirmed the diagnosis of benign focal epilepsy of childhood, which was treated with carbamazepine. The symptoms resolved after eight weeks and the repeat reflux investigations were essentially normal. Oropharyngeal symptoms are common in benign focal epilepsy of childhood, a condition which is very responsive to therapy. Symptoms suggestive of this diagnosis - acute onset, with unusual oropharyngeal sensations, or seizures-occurring mainly at night may initially be confused with gastroesophageal reflux. Benign focal epilepsy of childhood should be considered in reflux presenting outside infancy.

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