scholarly journals P16‐55: Additional effects of macrolides on steroid pulse therapy in patients with acute exacerbation of interstitial lung disease

Respirology ◽  
2021 ◽  
Vol 26 (S3) ◽  
pp. 471-472
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Acute Exacerbation ◽  
Pulse Therapy ◽  
Steroid Pulse Therapy ◽  
Steroid Pulse

scholarly journals Interstitial lung disease associated with adjuvant and neoadjuvant chemotherapy in early breast cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kenji Tezuka ◽  
Kotaro Miura ◽  
Yusuke Nakano ◽  
Takahiro Ueda ◽  
Kyoko Yagyu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Interstitial Lung Disease ◽  
Neoadjuvant Chemotherapy ◽  
Lung Disease ◽  
Early Stage ◽  
Pulse Therapy ◽  
Clinicopathological Characteristics ◽  
Breast Cancer Patients ◽  
Steroid Pulse ◽  
Dose Dense

Abstract Background Interstitial lung disease (ILD) is a rare adverse event in patients receiving adjuvant or neoadjuvant chemotherapy (NAC) for breast cancer. Few studies have reported the frequency of ILD in detail, and only small numbers of cases have been described in the literature. Given these previous findings concerning ILD, we retrospectively examined the clinicopathological characteristics of five cases of ILD who had received epirubicin and cyclophosphamide (EC) and compared their findings with non-ILD cases. Methods The present single-center retrospective study included breast cancer patients who underwent adjuvant chemotherapy or NAC at our hospital between January 2014 and January 2021. Results Thirty-nine patients who had received EC for operable breast cancer were enrolled in this study. ILD developed 5 out of 39 patients (12.8%). The incidence of ILD in patients with non-dose-dense (dd) or dd chemotherapy was statistically significantly different (p = 0.0149). ILD occurred in three patients during dd EC treatment and two during weekly paclitaxel (wPTX) after dd EC. ILD was detected in one patient with high Krebs von den Lungen-6 (KL-6) levels, in two patients with continuous pyrexia, and in two patients from computed tomography imaging, which was taken to estimate the efficacy of chemotherapy, in two patients. Three of the 5 ILD patients underwent bronchoalveolar lavage, and 2 of these patients were diagnosed with Pneumocystis jirovecii pneumonia (PCP). There were no cases of serious ILD that required steroid pulse therapy. Conclusions Dd chemotherapy may be associated with an increased ILD frequency, which may reflect developing PCP. Careful monitoring and a timely diagnosis are useful for detecting early-stage ILD.

scholarly journals Risk factors for acute exacerbation in lung cancer complicated by interstitial lung disease with slight reticular shadows

2021 ◽  
Author(s):  
Yutaka Takahara ◽  
Takuya Tanaka ◽  
Yoko Ishige ◽  
Ikuyo Shionoya ◽  
Kouichi Yamamura ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Acute Exacerbation

scholarly journals A Kidney Transplant Recipient with Recurrent Henoch-Schönlein Purpura Nephritis Successfully Treated with Steroid Pulse Therapy and Epipharyngeal Abrasive Therapy

Nephron ◽  
2020 ◽  
pp. 1-5
Author(s):  
Mika Fujimoto ◽  
Kan Katayama ◽  
Kouhei Nishikawa ◽  
Shoko Mizoguchi ◽  
Keiko Oda ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Transplantation ◽  
Transplant Recipient ◽  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Pulse Therapy ◽  
Steroid Pulse Therapy ◽  
Steroid Pulse ◽  
Schonlein Purpura ◽  
Purpura Nephritis

There is no specific treatment for recurrent Henoch-Schönlein purpura nephritis (HSPN) in a transplanted kidney. We herein report a case of a kidney transplant recipient with recurrent HSPN that was successfully treated with steroid pulse therapy and epipharyngeal abrasive therapy (EAT). A 39-year-old Japanese man developed HSPN 4 years ago and had to start hemodialysis after 2 months despite receiving steroid pulse therapy followed by oral prednisolone, plasma exchange therapy, and cyclophosphamide pulse therapy. He had undergone tonsillectomy 3 years earlier in the hopes of achieving a better outcome of a planned kidney transplantation and received a living-donor kidney transplantation from his mother 1 year earlier. Although there were no abnormalities in the renal function or urinalysis 2 months after transplantation, a routine kidney allograft biopsy revealed evidence of mesangial proliferation and cellular crescent formation. Mesangial deposition for IgA and C3 was noted, and he was diagnosed with recurrent HSPN histologically. Since the renal function and urinalysis findings deteriorated 5 months after transplantation, 2 courses of steroid pulse therapy were performed but were ineffective. EAT using 0.5% zinc chloride solution once per day was combined with the third course of steroid pulse therapy, as there were signs of chronic epipharyngitis. His renal function recovered 3 months after daily EAT and has been stable for 1.5 years since transplantation. Daily EAT continued for >3 months might be a suitable strategy for treating recurrent HSPN in cases of kidney transplantation.

scholarly journals COVID-19and Acute Exacerbation of Interstitial Lung Disease

2021 ◽  
Author(s):  
Yasuhiro Kondoh ◽  
Kensuke Kataoka ◽  
Masaru Ando ◽  
Yukikazu Awaya ◽  
Kazuya Ichikado ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Acute Exacerbation
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