scholarly journals Inferring within‐flock transmission dynamics of highly pathogenic avian influenza H5N8 virus in France, 2020

Author(s):  
Timothée Vergne ◽  
Simon Gubbins ◽  
Claire Guinat ◽  
Billy Bauzile ◽  
Mattias Delpont ◽  
...  

Viruses ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1389 ◽  
Author(s):  
Sol Jeong ◽  
Dong-Hun Lee ◽  
Jung-Hoon Kwon ◽  
Yu-Jin Kim ◽  
Sun-Hak Lee ◽  
...  

In October 2020, a highly pathogenic avian influenza (HPAI) subtype H5N8 virus was identified from a fecal sample of a wild mandarin duck (Aix galericulata) in South Korea. We sequenced all eight genome segments of the virus, designated as A/Mandarin duck/Korea/K20-551-4/2020(H5N8), and conducted genetic characterization and comparative phylogenetic analysis to track its origin. Genome sequencing and phylogenetic analysis show that the hemagglutinin gene belongs to H5 clade 2.3.4.4 subgroup B. All genes share high levels of nucleotide identity with H5N8 HPAI viruses identified from Europe during early 2020. Enhanced active surveillance in wild and domestic birds is needed to monitor the introduction and spread of HPAI via wild birds and to inform the design of improved prevention and control strategies.



Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 691
Author(s):  
Dae-Sung Yoo ◽  
Byungchul Chun ◽  
Kyung-Duk Min ◽  
Jun-Sik Lim ◽  
Oun-Kyoung Moon ◽  
...  

Highly pathogenic avian influenza (HPAI) virus is one of the most virulent and infectious pathogens of poultry. As a response to HPAI epidemics, veterinary authorities implement preemptive depopulation as a controlling strategy. However, mass culling within a uniform radius of the infection site can result in unnecessary depopulation. Therefore, it is useful to quantify the transmission distance from infected premises (IPs) before determining the optimal area for preemptive depopulation. Accordingly, we analyzed the transmission risk within spatiotemporal clusters of IPs using transmission kernel estimates derived from phylogenetic clustering information on 311 HPAI H5N6 IPs identified during the 2016–2017 epidemic, Republic of Korea. Subsequently, we explored the impact of varying the culling radius on the local transmission of HPAI given the transmission risk estimates. The domestic duck farm density was positively associated with higher transmissibility. Ring culling over a radius of 3 km may be effective for areas with high dense duck holdings, but this approach does not appear to significantly reduce the risk for local transmission in areas with chicken farms. This study provides the first estimation of the local transmission dynamics of HPAI in the Republic of Korea as well as insight into determining an effective ring culling radius.



2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
I Chatziprodromidou ◽  
S Tavornpanich ◽  
M Arvanitidou ◽  
E Brun ◽  
J Guitian ◽  
...  


2017 ◽  
Vol 23 (12) ◽  
pp. 2050-2054 ◽  
Author(s):  
Erik Kleyheeg ◽  
Roy Slaterus ◽  
Rogier Bodewes ◽  
Jolianne M. Rijks ◽  
Marcel A.H. Spierenburg ◽  
...  


2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
I Chatziprodromidou ◽  
S Tavornpanich ◽  
M Arvanitidou ◽  
E Brun ◽  
J Guitian ◽  
...  


2016 ◽  
Vol 21 (38) ◽  
Author(s):  
Marjolein J Poen ◽  
Josanne H Verhagen ◽  
Ruth J Manvell ◽  
Ian Brown ◽  
Theo M Bestebroer ◽  
...  

In 2014, H5N8 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) viruses of the A/Goose/Guangdong/1/1996 lineage emerged in poultry and wild birds in Asia, Europe and North America. Here, wild birds were extensively investigated in the Netherlands for HPAI H5N8 virus (real-time polymerase chain reaction targeting the matrix and H5 gene) and antibody detection (haemagglutination inhibition and virus neutralisation assays) before, during and after the first virus detection in Europe in late 2014. Between 21 February 2015 and 31 January 2016, 7,337 bird samples were tested for the virus. One HPAI H5N8 virus-infected Eurasian wigeon (Anas penelope) sampled on 25 February 2015 was detected. Serological assays were performed on 1,443 samples, including 149 collected between 2007 and 2013, 945 between 14 November 2014 and 13 May 2015, and 349 between 1 September and 31 December 2015. Antibodies specific for HPAI H5 clade 2.3.4.4 were absent in wild bird sera obtained before 2014 and present in sera collected during and after the HPAI H5N8 emergence in Europe, with antibody incidence declining after the 2014/15 winter. Our results indicate that the HPAI H5N8 virus has not continued to circulate extensively in wild bird populations since the 2014/15 winter and that independent maintenance of the virus in these populations appears unlikely.



2017 ◽  
Vol 23 (12) ◽  
pp. 1974-1981 ◽  
Author(s):  
Nancy Beerens ◽  
Rene Heutink ◽  
Saskia A. Bergervoet ◽  
Frank Harders ◽  
Alex Bossers ◽  
...  


2021 ◽  
Vol 26 (24) ◽  
Author(s):  
Olga G Pyankova ◽  
Ivan M Susloparov ◽  
Anastasia A Moiseeva ◽  
Natalia P Kolosova ◽  
Galina S Onkhonova ◽  
...  

This study presents the isolation of influenza A(H5N8) virus clade 2.3.4.4b from a poultry worker during an outbreak of highly pathogenic avian influenza A(H5N8) among chickens at a poultry farm in Astrakhan, Russia in December 2020. Nasopharyngeal swabs collected from seven poultry workers were positive for influenza A(H5N8), as confirmed by RT-PCR and sequencing. The influenza A(H5N8) virus was isolated from one of the human specimens and characterised. Sporadic human influenza A(H5)2.3.4.4. infections represent a possible concern for public health.



2020 ◽  
Author(s):  
Nancy Beerens ◽  
Rene Heutink ◽  
Frank Harders ◽  
Marit Roose ◽  
Sylvia B.E. Pritz-Verschuren ◽  
...  

AbstractThe HPAI H5N8 virus detected in mute swans in the Netherlands in October 2020 shares a common ancestor with clade 2.3.4.4b viruses last detected in Egypt in 2018-2019 and has a similar genetic composition. The virus is not directly related to European H5N8 viruses detected in first half of 2020.



2021 ◽  
Vol 27 (11) ◽  
pp. 2856-2863
Author(s):  
Tobias Floyd ◽  
Ashley C. Banyard ◽  
Fabian Z.X. Lean ◽  
Alexander M.P. Byrne ◽  
Edward Fullick ◽  
...  


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