scholarly journals Hepatic ischemia reperfusion injury is associated with acute kidney injury following donation after brain death liver transplantation

2013 ◽  
Vol 26 (11) ◽  
pp. 1116-1125 ◽  
Author(s):  
Joanna A. Leithead ◽  
Matthew J. Armstrong ◽  
Christopher Corbett ◽  
Mark Andrew ◽  
Chirag Kothari ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Brain Death ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Hepatic Ischemia ◽  
Donation After Brain Death ◽  
Hepatic Ischemia Reperfusion

scholarly journals Hepatic ischemia/reperfusion injury associates with acute kidney injury in liver transplantation: Prospective cohort study

2017 ◽  
Vol 23 (5) ◽  
pp. 634-644 ◽  
Author(s):  
Ina Jochmans ◽  
Nicolas Meurisse ◽  
Arne Neyrinck ◽  
Marleen Verhaegen ◽  
Diethard Monbaliu ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Cohort Study ◽  
Reperfusion Injury ◽  
Prospective Cohort ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

Prevention of Hepatic Ischemia/Reperfusion Injury by Microcirculatory Regulation: Application to Liver Transplantation

2001 ◽  
pp. 277-282
Author(s):  
Motohide Shimazu ◽  
Go Wakabayashi ◽  
Minoru Tanabe ◽  
Shigeyuki Kawachi ◽  
Kenji Iwata ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals Iron overload as a risk factor for hepatic ischemia‐reperfusion injury in liver transplantation: Potential role of ferroptosis

2020 ◽  
Vol 20 (6) ◽  
pp. 1606-1618 ◽  
Author(s):  
Naoya Yamada ◽  
Tadayoshi Karasawa ◽  
Taiichi Wakiya ◽  
Ai Sadatomo ◽  
Homare Ito ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Risk Factor ◽  
Iron Overload ◽  
Reperfusion Injury ◽  
Potential Role ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

scholarly journals OC-063 The severity of hepatic ischaemia-reperfusion injury is associated with acute kidney injury following donation after brain death liver transplantation

Gut ◽  
2012 ◽  
Vol 61 (Suppl 2) ◽  
pp. A27.2-A27
Author(s):  
J A Leithead ◽  
M J Armstrong ◽  
C Corbett ◽  
M Andrew ◽  
C Kothari ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Acute Kidney Injury ◽  
Brain Death ◽  
Reperfusion Injury ◽  
Kidney Injury ◽  
Ischaemia Reperfusion Injury ◽  
Ischaemia Reperfusion ◽  
Donation After Brain Death

scholarly journals MicroRNA-141-3p Attenuates Oxidative Stress-induced Hepatic Ischemia Reperfusion Injury via Keap1/Nrf2 Pathway

2021 ◽  
Author(s):  
Tingting Li ◽  
Qingsong Chen ◽  
Jiangwen Dai ◽  
Zuotian Huang ◽  
Yunhai Luo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Inflammatory Responses ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Hepatic Ischemia ◽  
Hepatic Ischemia Reperfusion

Abstract Hepatic ischemia reperfusion injury (IRI) is a major factor affecting the prognosis of liver transplantation through a series of severe cell death and inflammatory responses. MicroRNA-141-3p (miR-141-3p) has been reported to be associated with hepatic steatosis and other liver diseases. However, the potential role of miR-141-3p in hepatic IRI is currently unknown. In the present study, we found that miR-141-3p levels were negatively correlated with alanine aminotransferase (ALT)/aspartate aminotransferase (AST) in liver transplantation patients. The results demonstrated that miR-141-3p was decreased in mouse liver tissue after hepatic IRI in mice and in hepatocytes after hypoxia/reoxygenation (H/R). Overexpression of miR-141-3p directly decreased Kelch-like ECH-associated protein 1 (Keap1) levels and attenuated cell apoptosis in vivo and in vitro, while inhibition of miR-141-3p facilitated apoptosis. Further experiments revealed that overexpression of miR-141-3p also attenuated oxidative stress-induced damage in hepatocytes under H/R conditions. Taken together, our results indicate that miR-141-3p plays a major role in hepatic IRI through the Keap1 signaling pathway, and the present study suggests that miR-141-3p might have a protective effect on hepatic IRI to some extent.

Effect of dexmedetomidine on hepatic ischemia-reperfusion injury in the setting of adult living donor liver transplantation

2016 ◽  
Vol 30 (4) ◽  
pp. 470-482 ◽  
Author(s):  
Nirmeen A. Fayed ◽  
Eman I. Sayed ◽  
Sherif M. Saleh ◽  
Nermen A. Ehsan ◽  
Ashraf Y. Elfert
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Living Donor ◽  
Living Donor Liver Transplantation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Donor Liver ◽  
Hepatic Ischemia ◽  
Donor Liver Transplantation ◽  
Hepatic Ischemia Reperfusion
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