Comparison of pregnancy outcomes in Dutch kidney recipients with and without calcineurin inhibitor exposure; a retrospective study

Abstract Objective: This retrospective study aimed to explore the optimal endometrial preparation method in women with intrauterine adhesions (IUAs).Method: A total of 882 frozen-thawed embryo transfer (FET) cycles from patients with history of IUAs were categorized into three groups based on endometrial preparation methods: hormone replacing therapy cycle (HRT, n=636), natural cycle (NC n=174), and HRT with GnRH-a pretreatment (HRT+GnRH-a, n=72. Logistic regression was performed to investigate the association between cycle regimens and pregnancy outcomes. Subgroup analysis of IUAs combined with thin endometrium (≤7mm) was also performed.Results: HRT with GnRH-a pretreatment was associated with higher incidences of clinical pregnancy, ongoing pregnancy, and live birth, but lower early miscarriage compared with either HRT or NC. Logistic regression indicated that after controlling for potential confounders, the incidences of live birth (HRT+GnRH-a as reference; NC: aOR=0.577, 95%CI 0.304-1.093; HRT: aOR=0.434, 95%CI 0.247-0.765) and ongoing pregnancy (NC: aOR=0.614, 95%CI 0.324-1.165; HRT: aOR=0.470, 95%CI 0.267-0.829) remained significantly higher in HRT+GnRH-a compared to those in HRT, but comparable to those in NC. While there was no significant difference with respect to the clinical pregnancy rate (NC: aOR=0.695, 95%CI 0.374-1.291; HRT: aOR=0.650, 95%CI 0.374-1.127) and early miscarriage rate (NC: aOR=1.734, 95%CI 0.417-7.175; HRT: aOR=2.594, 95%CI 0.718-9.378) between groups. Subgroup analysis suggested there was no superiority of endometrial preparation method in IUAs combined with thin endometrium.Conclusion: HRT with GnRH-a pretreatment improves pregnancy outcomes in women with history of IUAs. GnRH-a may restore the endometrial receptivity in the FET cycles in IUAs.

Download Full-text

Pregnancy Outcome in Uterine Anomalies

The Journal of Medical Sciences ◽

10.5005/jp-journals-10045-0052 ◽

2017 ◽

Vol 3 (1) ◽

pp. 31-33

Author(s):

Nagendra Prasad ◽

James Thingujam

Keyword(s):

Retrospective Study ◽

Pregnancy Outcome ◽

Pregnancy Outcomes ◽

Intrauterine Growth Restriction ◽

Preterm Labor ◽

Premature Rupture ◽

Intrauterine Growth ◽

Preterm Premature Rupture ◽

Uterine Anomalies ◽

Uterine Anomaly

ABSTRACT Maternal with congenitial anomalies are known to have higher incidence of infertility, intrauterine growth restriction, fetal malposition, preterm labor, preterm premature rupture of membrane and increased cesaerean section rate. Study Design This is retrospective study, the pregnancies with uterine anomaly confirmed by ultrasound between Jan 2016 to jan 2017 at our hospital was taken and its outcome is observed. Reults The majority of preterm delivery in our study are mainly associated with septate and bicornuate uterus. Cesaerean section comprised of 80% and its major indication is due to fetal malpresentation (breech). Thus Pregnancy outcomes of individual depending on the type of uterine anomalies. How to cite this article Nagarathnamma R, James T, Prasad N. Pregnancy Outcome in Uterine Anomalies. J Med Sci 2017;3(1):31-33.

Download Full-text

Erratum to Ruffatti et al. “Treatment strategies and pregnancy outcomes in antiphospholipid syndrome patients with thrombosis and triple antiphospholipid positivity. A European multicenter retrospective study” (Thromb Haemost 2014; 112: 727-725)

Thrombosis and Haemostasis ◽

10.1160/th14120001 ◽

2014 ◽

Vol 112 (12) ◽

pp. 1327-1327

Keyword(s):

Retrospective Study ◽

Antiphospholipid Syndrome ◽

Pregnancy Outcomes ◽

Treatment Strategies ◽

Al Treatment

Download Full-text

Emergency cervical cerclage and pregnancy outcomes

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20171964 ◽

2017 ◽

Vol 6 (5) ◽

pp. 1993

Author(s):

N. Nagendra Prasad ◽

Sherin Annamma Thampan ◽

R. Nagarathnamma

Keyword(s):

Retrospective Study ◽

Spontaneous Abortion ◽

Pregnancy Outcomes ◽

Cervical Dilatation ◽

Second Trimester ◽

Cervical Cerclage ◽

Live Births ◽

Term Delivery

Background: To evaluate the effectiveness and safety of emergency cervical cerclage in women who presented with advanced cervical changes such as cervical dilatation and bulging foetal membranes.Methods: This is a retrospective study on all women treated with cervical cerclage presented in the late second trimester with advanced cervical dilatation (2 to 4cms) for whom emergency cervical cerclage by McDonald technique.Results: Out of the 24 patients for whom emergency cervical cerclage was performed, three patients had spontaneous abortion after cervical cerclage, two had PROM and eight of these patients had term delivery. Twenty-one fetus were live born after the period of viability. Nine of these babies were admitted to NICU and 50 percent of the neonates required only regular perinatal care.Conclusions: Post emergency cervical cerclage, the outcome in terms of prolongation of pregnancy, live births and neonatal survival is better.

Download Full-text