scholarly journals Estimating the risks of prehospital transfusion of D‐positive whole blood to trauma patients who are bleeding in England

Vox Sanguinis ◽  
2022 ◽  
Author(s):  
Rebecca Cardigan ◽  
Tom Latham ◽  
Anne Weaver ◽  
Mark Yazer ◽  
Laura Green
Keyword(s):  
Whole Blood ◽  
Trauma Patients

Autotransfusion of hemothorax blood in trauma patients: is it the same as fresh whole blood?

2011 ◽  
Vol 202 (6) ◽  
pp. 817-822 ◽  
Author(s):  
Marc Salhanick ◽  
Michael Corneille ◽  
Russell Higgins ◽  
John Olson ◽  
Joel Michalek ◽  
...  
Keyword(s):  
Whole Blood ◽  
Trauma Patients

The use of low-titer group O whole blood for the resuscitation of civilian trauma patients in 2018

Transfusion ◽  
2018 ◽  
Vol 58 (11) ◽  
pp. 2744-2746 ◽  
Author(s):  
Mark H. Yazer ◽  
Philip C. Spinella
Keyword(s):  
Whole Blood ◽  
Trauma Patients ◽  
Civilian Trauma ◽  
Titer Group

The use of prehospital blood products in the resuscitation of trauma patients: a review of prehospital transfusion practices and a description of our regional whole blood program in San Antonio, TX

2019 ◽  
Vol 14 (3) ◽  
pp. 332-342 ◽  
Author(s):  
Douglas M. Pokorny ◽  
Maxwell A. Braverman ◽  
Philip M. Edmundson ◽  
David M. Bittenbinder ◽  
Caroline S. Zhu ◽  
...  
Keyword(s):  
Whole Blood ◽  
San Antonio ◽  
Trauma Patients ◽  
Blood Products

scholarly journals Effects of Blood Sample Age at Time of Separation on Measured Cytokine Concentrations in Human Plasma

2010 ◽  
Vol 18 (2) ◽  
pp. 318-326 ◽  
Author(s):  
Rachael P. Jackman ◽  
Garth H. Utter ◽  
John W. Heitman ◽  
Dale F. Hirschkorn ◽  
Jacqueline P. Law ◽  
...  
Keyword(s):  
Whole Blood ◽  
Peripheral Blood ◽  
Blood Protein ◽  
Blood Collection ◽  
Trauma Patients ◽  
Immune Mediators ◽  
Blood Cytokines ◽  
Wide Range ◽  
Significant Change ◽  
Sample Age

ABSTRACTMeasurement of peripheral blood cytokines and other immunomodulatory proteins is a useful and popular tool for assessing human immune responses to a wide range of assaults. A common challenge in this work is obtaining fresh, high-quality samples and limiting the time between blood collection and the separation of plasma or serum from cells. In this study we sought to determine the effect of sample age at the time of processing on the measured levels of 41 soluble immune mediators. Two cohorts were examined: healthy lab donors and trauma patients, who have significant immune perturbation. Whole-blood samples were aliquoted, and plasma was isolated, at days 0, 1, 2, and 3 after collection. Multiplexing techniques were used to measure protein concentrations, and general estimating equations were used to determine if there was a significant change over time. Over the 3-day period examined, only 15 of the 41 proteins showed no significant change in either cohort. Among the remaining proteins both increases and decreases were observed, with changes ranging from 2.4% per day to 325% per day. Proteins with significant changes in one cohort did not always show significant changes in the other group. These results support the need to separate plasma or serum from whole blood as quickly as possible and/or to standardize the length of time to processing within a given study of peripheral blood protein concentrations. When this is not possible, care should be taken to account for differences due to sample age.

scholarly journals An Evaluation of the Role of Gene Expression in the Prediction and Diagnosis of Ventilator-associated Pneumonia

2011 ◽  
Vol 115 (2) ◽  
pp. 344-352 ◽  
Author(s):  
Julien Textoris ◽  
Béatrice Loriod ◽  
Laurent Benayoun ◽  
Pierre-Antoine Gourraud ◽  
Denis Puthier ◽  
...  
Keyword(s):  
Whole Blood ◽  
Injury Severity ◽  
Predictive Biomarker ◽  
Transcriptional Analysis ◽  
Trauma Patients ◽  
Ventilator Associated Pneumonia ◽  
Proinflammatory Response ◽  
Blood Samples ◽  
Severity Scores ◽  
Whole Blood Samples

Background The SepsiChip project explored transcriptional modulation associated with ventilator-associated pneumonia (VAP) in patients admitted to the intensive care unit for trauma. Genome-wide expression analysis may help to identify potential diagnostic markers for diseases. The current study examined the changes in blood transcriptome during VAP. Methods The authors prospectively included 165 trauma patients, and 41 developed VAP. Whole blood samples were collected at admission and at VAP. To predict VAP, the admission samples were compared by microarray in patients who did or did not develop VAP. To identify diagnosis markers, paired samples of 35 patients who developed VAP were analyzed. Using NanoString (Seattle, WA), the results were confirmed in the patients who developed VAP. Trauma patients who did not develop VAP served as controls to eliminate a time effect. Results The injury severity scores of the patients who did or did not develop VAP were 36 and 29, respectively. No predictive biomarker was identified. For patients who developed VAP, a transcriptional signature was identified between the two sampling times. However, this signature was a generalized pattern related to trauma, independent of the infectious process. Genes involved in the proinflammatory response were down-regulated in the patients who developed VAP, but this difference was not statistically significant. Conclusions In contrast to clinical assessment, transcriptional analysis of whole blood samples cannot predict or diagnose VAP in trauma patients. Differentiating infection from inflammation seems challenging.

scholarly journals Is the Whole Greater than the Sum of Its Parts? The Implementation and Outcomes of a Whole Blood Program in Ecuador

2021 ◽  
Author(s):  
Amber Nicole Himmler ◽  
Monica Eulalia Galarza Armijos ◽  
Jeovanni Reinoso Naranjo ◽  
Sandra Gioconda Peña Patiño ◽  
Doris Sarmiento Altamirano ◽  
...  
Keyword(s):  
Latin America ◽  
Hemorrhagic Shock ◽  
Whole Blood ◽  
Vital Signs ◽  
Human Albumin ◽  
Acute Care Surgery ◽  
Trauma Patients ◽  
Transfusion Reaction ◽  
Shock Index ◽  
Care Surgery

Abstract Background: Hemorrhagic shock is a major cause of mortality in low-and-middle-income countries (LMICs). Many institutions in LMICs lack the resources to adequately prescribe balanced resuscitation. This study aims to describe the implementation of a whole blood program in Latin America and to discuss the outcomes of the patients that received whole blood (WB).Methods: We conducted a retrospective review of patients resuscitated with WB from 2013-2019. Five units of O+ WB were made available on a consistent basis for patients presenting in hemorrhagic shock. Variables collected included: gender, age, service treating the patient, units of WB administered, units of components administered, admission vital signs, admission hemoglobin, Shock Index, Revised Trauma Score (RTS) in trauma patients, intraoperative crystalloid (lactated ringers or normal saline) and colloid (5% human albumin) administration, symptoms of transfusion reaction, length-of-stay and in-hospital mortality.Results: The sample includes a total of 101 patients, 57 of whom were trauma and acute care surgery (TACS) patients and 44 of whom were obstetrics and gynecology patients. No patients developed symptoms consistent with a transfusion reaction. Average shock index was 1.16 (±0.55). On average, patients received 1.66 (±0.80) units of whole blood. Overall mortality was 14/101 (13.86%) in the first 24 hours and 6/101 (5.94%) after 24 hours.Conclusion: Implementing a WB protocol is achievable in LMICs. Whole blood allows for more efficient delivery of hemostatic resuscitation and is ideal for resource-restrained settings. To our knowledge, this is the first description of a whole blood program implemented in a civilian hospital in Latin America.

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