scholarly journals Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date

2015 ◽  
Vol 22 (4) ◽  
pp. 302-309 ◽  
Author(s):  
Hayato Iwase ◽  
Hong Liu ◽  
Martin Wijkstrom ◽  
Huidong Zhou ◽  
Jagjit Singh ◽  
...  
Keyword(s):  
Graft Survival ◽  
Kidney Graft ◽  
Pig Kidney ◽  
Organ Graft

scholarly journals Bringing Home The Bacon: Update on The State of Kidney Xenotransplantation

2018 ◽  
Vol 45 (1-3) ◽  
pp. 254-259 ◽  
Author(s):  
David K.C. Cooper ◽  
H. Iwase ◽  
L. Wang ◽  
T. Yamamoto ◽  
Qi Li ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Kidney Transplantation ◽  
Graft Survival ◽  
Cellular Response ◽  
Genetic Manipulation ◽  
Immunosuppressive Agents ◽  
Cross Reactivity ◽  
Genetically Engineered ◽  
Kidney Graft ◽  
Pig Kidney

Background: There is a continuing critical shortage of organs from deceased human donors for transplantation, particularly for patients awaiting kidney transplantation. Efforts are being made to resolve the donor kidney shortage by the transplantation of kidneys from genetically-engineered pigs. Summary: This review outlines the pathobiological barriers to pig organ xenotransplantation in primates, which include (i) antibody-dependent complement-mediated rejection, (ii) a T cell-mediated elicited antibody and cellular response, (iii) coagulation dysregulation between pigs and primates, and (iv) a persistent inflammatory response. As a result of increasing genetic manipulation of the pig and the introduction of novel immunosuppressive agents, pig kidney graft survival has increased from minutes to months, and even to >1 year in some cases. Aspects of the selection of the patients for a first clinical trial are discussed. Although there would appear to be some cross-reactivity between anti-human leukocyte antigen (HLA) antibodies and swine leukocyte antigens expressed in pigs, some HLA-sensitized patients will be at no disadvantage if they receive a pig kidney. Furthermore, the current limited evidence is that, even if the patient becomes sensitized to pig antigens (after a pig organ transplant), this would not be detrimental to a subsequent allotransplant. The potential risk of infection with a pig microorganism, and the function of a pig kidney in a primate are also discussed. Key Message: The recent encouraging results of pig kidney transplantation in nonhuman primates suggest the likelihood of a successful (and safe) initial clinical trial, with graft survival for months or possibly years.

scholarly journals Myroides Infection in a Baboon After Prolonged Pig Kidney Graft Survival

2015 ◽  
Vol 1 (4) ◽  
pp. 1-5 ◽  
Author(s):  
Hong Liu ◽  
Hayato Iwase ◽  
Martin Wijkstrom ◽  
Jagjit Singh ◽  
Edwin Klein ◽  
...  
Keyword(s):  
Graft Survival ◽  
Kidney Graft ◽  
Pig Kidney

scholarly journals POS-701 OVER TEN-YEARS KIDNEY GRAFT SURVIVAL DETERMINANTS : A SINGLE CENTER EXPERIENCE

2021 ◽  
Vol 6 (4) ◽  
pp. S306
Author(s):  
S. AYED ◽  
M. Ben salem ◽  
M. Hammouda ◽  
A. Letaief ◽  
M. Ben salah ◽  
...  
Keyword(s):  
Graft Survival ◽  
Kidney Graft ◽  
Single Center ◽  
Single Center Experience

scholarly journals Impact of Early Pancreatic Graft Loss on Outcome after Simultaneous Pancreas–Kidney Transplantation (SPKT)—A Landmark Analysis

2021 ◽  
Vol 10 (15) ◽  
pp. 3237
Author(s):  
Lukas Johannes Lehner ◽  
Robert Öllinger ◽  
Brigitta Globke ◽  
Marcel G. Naik ◽  
Klemens Budde ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Type I ◽  
Kidney Graft ◽  
Landmark Analysis ◽  
Pancreas Kidney Transplantation ◽  
Simultaneous Pancreas Kidney ◽  
Simultaneous Pancreas Kidney Transplantation ◽  
Pancreas Graft

(1) Background: Simultaneous pancreas–kidney transplantation (SPKT) is a standard therapeutic option for patients with diabetes mellitus type I and kidney failure. Early pancreas allograft failure is a complication potentially associated with worse outcomes. (2) Methods: We performed a landmark analysis to assess the impact of early pancreas graft loss within 3 months on mortality and kidney graft survival over 10 years. This retrospective single-center study included 114 adult patients who underwent an SPKT between 2005 and 2018. (3) Results: Pancreas graft survival rate was 85.1% at 3 months. The main causes of early pancreas graft loss were thrombosis (6.1%), necrosis (2.6%), and pancreatitis (2.6%). Early pancreas graft loss was not associated with reduced patient survival (p = 0.168) or major adverse cerebral or cardiovascular events over 10 years (p = 0.741) compared to patients with functioning pancreas, after 3 months. Moreover, kidney graft function (p = 0.494) and survival (p = 0.461) were not significantly influenced by early pancreas graft loss. (4) Conclusion: In this study, using the landmark analysis technique, early pancreas graft loss within 3 months did not significantly impact patient or kidney graft survival over 10 years.

Influence of HLA-A and HLA-B cross-reactive antigen matching on kidney graft survival

1981 ◽  
Vol 18 (2) ◽  
pp. 101-104 ◽  
Author(s):  
Raynald Roy ◽  
Yves Fradet ◽  
Jean-Guy Lachance
Keyword(s):  
Graft Survival ◽  
Kidney Graft

Influence of specific thoracic donor therapy on kidney donation and long-term kidney graft survival

2016 ◽  
Vol 30 (6) ◽  
pp. 869-875 ◽  
Author(s):  
María A. Ballesteros ◽  
Jorge Duerto Álvarez ◽  
Luis Martín-Penagos ◽  
Emilio Rodrigo ◽  
Manuel Arias ◽  
...  
Keyword(s):  
Graft Survival ◽  
Kidney Donation ◽  
Kidney Graft

Timing of Kidney Clamping and Deceased Donor Kidney Transplant Outcomes

2021 ◽  
pp. CJN.03290321
Author(s):  
Simon Ville ◽  
Marine Lorent ◽  
Clarisse Kerleau ◽  
Anders Asberg ◽  
Christophe Legendre ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Graft Survival ◽  
Ischemia Reperfusion ◽  
Multivariable Analysis ◽  
Graft Function ◽  
Deceased Donor ◽  
Kidney Graft ◽  
Kidney Transplant Recipients ◽  
Heart Beating ◽  
Deceased Donor Kidney Transplant

BackgroundThe recognition that metabolism and immune function are regulated by an endogenous molecular clock generating circadian rhythms suggests that the magnitude of ischemia-reperfusion and subsequent inflammation on kidney transplantation, could be affected by the time of the day. MethodsAccordingly, we evaluated 5026 first kidney transplant recipients from deceased heart-beating donors. In a cause-specific multivariable analysis, we compare delayed graft function (DGF) and graft survival according to the time of kidney clamping and declamping. Participants were divided into clamping between midnight and noon (AM clamping group, 65%) or clamping between noon and midnight (PM clamping group, 35%), and similarly, AM declamping or PM declamping (25% / 75%). ResultsDGF occurred among 550 participants (27%) with AM clamping and 339 (34%) with PM clamping (adjusted OR = 0.81, 95%CI: 0.67 to 0.98, p= 0.03). No significant association of clamping time with overall death censored graft survival was observed (HR = 0.92, 95%CI: 0.77 to 1.10, p= 0.37). No significant association of declamping time with DGF or graft survival was observed. ConclusionsClamping between midnight and noon was associated with a lower incidence of DGF whilst the declamping time was not associated with kidney graft outcomes.

MO921PROGNOSTIC OUTCOMES OF TRANSPLANTED KIDNEY USING SOLUBLE  CD30 AND Β2- MICROGLOBULIN

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Ahmed Abo omar ◽  
Gamal Saadi
Keyword(s):  
Acute Rejection ◽  
Graft Survival ◽  
Patient Group ◽  
The Other ◽  
Kidney Graft ◽  
Post Transplantation ◽  
Β2 Microglobulin ◽  
Transplanted Kidney ◽  
Successful Transplantation

Abstract Background and Aims Transplantation is the first successful modality of renal replacement therapy (RRT) for irreversible chronic kidney disease (CKD; stage 5). Identifying additional factors associated with poor long-term prognosis after transplantation may provide clues regarding the pathophysiological mechanisms involved in allograft failure and identify high-risk patients who may benefit from additional monitoring or interventions. Successful kidney transplantation results in a substantial decrease in β2M levels, but a delayed decrease or increasing levels after transplantation may serve as a marker of acute rejection or inflammation. Several reports show that elevated sCD30 levels, pre and post transplantation are associated with a poor prognosis for long term kidney graft survival. These studies found higher CD30 levels in allograft recipients and a good predictor of impending acute rejection. The aim of the work is to study the prognostic outcomes of transplanted kidney using CD30 and β2-Microglobulin Method prospective study was conducted in nephrology unit –internal medicine department at Tanta and Kasr El Ainy university ,over 1 year.20 patients subjected to primary Tx.participated in this study.Cd30 and β2M.at day -1,2weeks and 3 months,with clinical follow up after 1 year to detect graft survival Results At day -1,level of cd30 was higher in rejection group than the other patient group.2 weeks post transplantation ,level of cd30 was higher in rejection group than the other patient group and at 3 monthes post transplantation level of cd30 was higher in rejection group than the other patient group,and these differences are statistically highly significant.(p values :0.003 ,0.005 and 0.002 respectively) Successful transplantation leads to significant decrease in serum cd30 at 2 weeks post tx.(P1 <0.005) and at 3 monthes post tx. (P1<0.001) although in rejection group, significant decrease in cd30 was at 2 weeks post tx.only(P1<0.005) and at 3 monthes serum cd30 began to rise again with( P1 0.157). At day -1,level of β2microglobulin was higher in rejection group than the other patient groupwith statistically significant difference (p. 0.01).2 weeks post transplantation ,level of β2microglobulin was higher in rejection group than the other patient groupbut statistically not significant(p. 0.18 ) and at 3 monthes post transplantation level of β2microglobulin was higher in rejection group than the other patient group but statistically non significant(p. 0.18 ). Successful transplantation leads to significant decrease in serum β2microglobulin at 2 weeks post tx.(P1 <0.002) and at 3 monthes post tx. (P1<0.001) although in rejection group ,significant decrease in β2microglobulin was at 3 monthes post tx.only(P1<0.005) and at 2 weeks no significant decrease(p1 0.15) Conclusion pre transplantation high Cd30 and β2M is associated with poor outcome.failure of decrease of cd30 and β2M post Tx. also associated with poor outcome or infection. Successful transplantation leads to significant decrease in serum cd30 and β2M. which can be used as predictors of graft survival with better sensitivity and specificity than serum creatinin.

Sign in / Sign up

Export Citation Format

Share Document